{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:42:00Z","timestamp":1790196120650,"version":"4.1.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology"],"published-print":{"date-parts":[[2002,5,14]]},"DOI":"10.1212\/wnl.58.9.1338","type":"journal-article","created":{"date-parts":[[2012,5,13]],"date-time":"2012-05-13T14:01:34Z","timestamp":1336917694000},"page":"1338-1347","source":"Crossref","is-referenced-by-count":153,"title":["Resection of the lesion in patients with hypothalamic hamartomas and catastrophic epilepsy"],"prefix":"10.1212","volume":"58","author":[{"given":"A.","family":"Palmini","sequence":"first","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chandler","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Andermann","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Costa da Costa","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Paglioli\u2013Neto","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Polkey","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Montes","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. V.","family":"Marti\u0301nez","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Farmer","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sinclair","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Aronyk","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Paglioli","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Coutinho","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Raupp","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Portuguez","sequence":"additional","affiliation":[{"name":"From the Porto Alegre Epilepsy Surgery Program (Drs. Palmini, Costa da Costa, Paglioli\u2013Neto, Martinez, Paglioli, Coutinho, Raupp, and Portuguez), Hospital Sa\u0303o Lucas da PUCRS, Brazil; the Department of Neurology and Neurosurgery (Dr. Andermann), Montreal Neurological Institute, McGill University, Quebec, Canada; the Department of Neurosurgery (Drs. Chandler and Polkey), King\u2019s College Hospital, London, United Kingdom; the Department of Neurology and Neurosurgery (Drs. Rosenblatt and Montes),..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"177","volume":"120","year":"1969","unstructured":"Paillas JE, Roger J, Toga M, et al. Hamartome de l\u2019hypothalamus: \u00e9tude clinique, radiologique, histologique. R\u00e9sultats de l\u2019ex\u00e9r\u00e8se Rev Neurol . 1969; 120: 177\u2013194.","journal-title":"R\u00e9sultats de l\u2019ex\u00e9r\u00e8se Rev Neurol"},{"key":"e_1_3_1_3_2","first-page":"757","volume":"40","year":"1983","unstructured":"Ponsot G, Diebler P, Plouin P, et al. Hamartomes hypothalamiques et crises de rire: a propos de 7 observations. Arch Fr Pediatr . 1983; 40: 757\u2013761.","journal-title":"Arch Fr Pediatr"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230502"},{"key":"e_1_3_1_5_2","first-page":"63","volume":"12","year":"1972","unstructured":"Gascon GG, Lombroso CT. Epileptic (gelastic) laughter. Epilepsia . 1972; 12: 63\u201376.","journal-title":"Epilepsia"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.4.757"},{"key":"e_1_3_1_7_2","first-page":"312","volume":"13","year":"1983","unstructured":"Plouin P, Ponsott G, Dulac O, Diebler C, Arthuis M. Hamartomes hypothalamiques et crises de rire. Rev EEG Neurophysiol . 1983; 13: 312\u2013316.","journal-title":"Rev EEG Neurophysiol"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.8.1180"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.11.2.253"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.4.747"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00263190"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb02470.x"},{"key":"e_1_3_1_13_2","first-page":"949","volume":"34","year":"1994","unstructured":"Valdueza JM, Cristante L, Dammann O, et al. Hypothalamic hamartomas: with special reference to gelastic epilepsy and surgery. Neurosurgery . 1994; 34: 949\u2013958.","journal-title":"Neurosurgery"},{"key":"e_1_3_1_14_2","first-page":"108","volume":"48","year":"2001","unstructured":"Rosenfeld JV, Harvey AS, Wrennall J, Zacharin M, Berkovic SF. Transcallosal resection of hypothalamic hamartomas, with control of seizures, in children with refractory epilepsy. Neurosurgery . 2001; 48: 108\u2013118.","journal-title":"Neurosurgery"},{"key":"e_1_3_1_15_2","first-page":"90","volume":"39","year":"1998","unstructured":"Delalande OR, Fohlen MJ, Jalin C, et al. Surgical treatment of epilepsy due to hypothalamic hamartoma: technique and preliminary results in five cases. Epilepsia . 1998; 39 (suppl 6): 90\u201391.","journal-title":"Epilepsia"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(95)00063-5"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420111"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270408"},{"key":"e_1_3_1_19_2","first-page":"1","volume":"38","year":"1997","unstructured":"Berkovic SF, Kuzniecky RI, Andermann F. Human epileptogenesis and hypothalamic hamartomas: new lessons from an experiment of nature. Epilepsia . 1997; 38: 1\u20133.","journal-title":"Epilepsia"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.4.971"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.6.1074"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.12.1725"},{"key":"e_1_3_1_23_2","unstructured":"Tassinari   CA Michelucci   R Shigematsu   H Seino   M.   Atonic and falling seizures.  In: Engel  J Jr ed.   Epilepsy: a comprehensive textbook.   Philadelphia:   Lippincott\u2013Raven 1997:  605\u2013616."},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01085.x"},{"key":"e_1_3_1_25_2","unstructured":"N\u2019Guyen JP K\u00e9ravel Y Racadot J. Vues anatomiques comment\u00e9es de l\u2019hypothalamus. Encycl M\u00e9d\u2013Chir Neurologie 17001 S10. Paris: \u00c9ditions Techniques 1991."},{"key":"e_1_3_1_26_2","unstructured":"Gloor   P.   The temporal lobe and limbic system.   New York:   Oxford University Press 1996."},{"key":"e_1_3_1_27_2","first-page":"725","volume":"20","year":"1940","unstructured":"Alpers BJ. Personality and emotional disorders associated with hypothalamic lesions. Res Publ Assoc Res Nerv Ment Dis . 1940; 20: 725\u2013752.","journal-title":"Res Publ Assoc Res Nerv Ment Dis"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480120062005"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510060081017"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/1988\/291847"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.8.3.164"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.78.1.0077"},{"key":"e_1_3_1_33_2","first-page":"211.","volume":"64","year":"1942","unstructured":"Bronstein IP, Luhan JA, Mavrelis WB. Sexual precocity asociated with hyperplastic malformation of the tuber cinereum. Am J Dis Child . 1942; 64: 211.","journal-title":"Am J Dis Child"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02595307"},{"key":"e_1_3_1_35_2","doi-asserted-by":"crossref","unstructured":"Meyer JE. Pubertas Praecox bei einer hyperplastischen Missbildung des Hypothalamus. In: Beitrag zur Frage des Sexualzentrums und der Neurosekretion im Zwischenhirn. Arch Psychiatr 1948;179:378.","DOI":"10.1007\/BF00353301"},{"key":"e_1_3_1_36_2","first-page":"484.","volume":"78","year":"1950","unstructured":"Seckel HP, Scott WW, Benditt EP. Six examples of precocious sexual development. A J Dis Child . 1950; 78: 484.","journal-title":"A J Dis Child"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-195011130-00002"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216980"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.1.279"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.91.5.0881"},{"key":"e_1_3_1_41_2","first-page":"1347","volume":"44","year":"1999","unstructured":"Fukuda M, Kameyama S, Wachi M, Tanaka R. Stereotaxy for hypothalamic hamartoma with intractable gelastic seizures. Technical case report. Neurosurgery . 1999; 44: 1347\u20131350.","journal-title":"Neurosurgery"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200012000-00014"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(00)00170-3"}],"container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.58.9.1338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T17:54:05Z","timestamp":1711648445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.58.9.1338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,14]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,5,14]]}},"alternative-id":["10.1212\/WNL.58.9.1338"],"URL":"https:\/\/doi.org\/10.1212\/wnl.58.9.1338","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,14]]}}}