{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:49:13Z","timestamp":1770479353514,"version":"3.49.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["neurology.org"],"crossmark-restriction":true},"short-container-title":["Neurology"],"published-print":{"date-parts":[[2008,10,21]]},"DOI":"10.1212\/01.wnl.0000327680.74910.93","type":"journal-article","created":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T20:28:15Z","timestamp":1224534495000},"page":"1361-1367","update-policy":"https:\/\/doi.org\/10.1212\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Cerebellar leukoencephalopathy"],"prefix":"10.1212","volume":"71","author":[{"given":"M. S.","family":"van der Knaap","sequence":"first","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"W.F.M.","family":"Arts","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"J. Y.","family":"Garbern","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"G.","family":"Hedlund","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"F.","family":"Winkler","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"C.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"M. D.","family":"King","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"A.","family":"Bj\u00f8rnstad","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"N.","family":"Hussain","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"M. K.","family":"Beyer","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"C.","family":"Gomez","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"M. C.","family":"Patterson","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"P.","family":"Grattan-Smith","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"M.","family":"Timmons","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]},{"given":"P.","family":"van der Valk","sequence":"additional","affiliation":[{"name":"From the Departments of Child Neurology (M.S.v.d.K.) and Neuropathology (P.v.d.V.), VU University Medical Center, Amsterdam, The Netherlands; Department of Pediatric Neurology (W.F.M.A.), Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; Department of Neurology and Center for Molecular Medicine and Genetics (J.Y.G.), Wayne State University, Detroit, MI; Pediatric Medical Imaging Department (G.H.), Primary Children\u2019s Medical Center, Salt Lake City, UT; Department of..."}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588038"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"Van der Knaap MS Valk J. Magnetic Resonance of Myelination and Myelin Disorders 3rd ed. Berlin: Springer; 2005.","DOI":"10.1007\/3-540-27660-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1071551"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370308"},{"key":"e_1_3_3_6_2","first-page":"1466","volume":"23","year":"2002","unstructured":"Van der Knaap MS, Naidu S, Pouwels PJW, et al. New syndrome characterized by hypomyelination with atrophy of the basal ganglia and cerebellum. Am J Neuroradiol 2002;23:1466\u20131474.","journal-title":"Am J Neuroradiol"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10456"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/422763"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1870"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/319519"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng764"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng2013"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2302021459"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520450071022"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-002-0842-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1971.tb03242.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199305000-00014"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.2.180"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199911)33:5<486::AID-MPO9>3.0.CO;2-J"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019709030915"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.05.031"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950180414"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70514-1"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1966.tb17661.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199711000-00005"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh403"},{"key":"e_1_3_3_27_2","first-page":"880","volume":"25","year":"2004","unstructured":"Prayer D, Grois N, Prosch H, Gadner H, Barkovich AJ. MR imaging presentation of intracranial disease associated with Langerhans cell histiocytosis. AJNR Am J Neuroradiol 2004;25:880\u2013891.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0509"},{"key":"e_1_3_3_29_2","first-page":"1921","volume":"15","year":"1994","unstructured":"Poe LB, Dubowy RL, Hochhauser L, et al. Demyelinating and gliotic cerebellar lesions in Langerhans cell histiocytosis. AJNR Am J Neuroradiol 1994;15:1921\u20131928.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70511-6"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307380001500302"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-0950-z"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0200-y"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0160-9"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.08.013"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070206"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70517-7"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910901)68:5<1050::AID-CNCR2820680524>3.0.CO;2-K"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-955086"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01125.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343902"}],"container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/01.wnl.0000327680.74910.93","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T14:27:18Z","timestamp":1711636038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/01.wnl.0000327680.74910.93"}},"subtitle":["Most likely histiocytosis-related"],"short-title":[],"issued":{"date-parts":[[2008,10,21]]},"references-count":40,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2008,10,21]]}},"alternative-id":["10.1212\/01.wnl.0000327680.74910.93"],"URL":"https:\/\/doi.org\/10.1212\/01.wnl.0000327680.74910.93","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,21]]}}}