{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:24:03Z","timestamp":1775183043743,"version":"3.50.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.neurology.org"],"crossmark-restriction":true},"short-container-title":["Neurology"],"published-print":{"date-parts":[[2016,1,5]]},"DOI":"10.1212\/wnl.0000000000002208","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T03:54:04Z","timestamp":1447905244000},"page":"79-87","update-policy":"https:\/\/doi.org\/10.1212\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":105,"title":["Pregnancy outcomes in aquaporin-4\u2013positive neuromyelitis optica spectrum disorder"],"prefix":"10.1212","volume":"86","author":[{"given":"Matthew M.","family":"Nour","sequence":"first","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Ichiro","family":"Nakashima","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Ester","family":"Coutinho","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Mark","family":"Woodhall","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Filipa","family":"Sousa","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Jon","family":"Revis","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Yoshiki","family":"Takai","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Jithin","family":"George","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Joanna","family":"Kitley","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Maria Ernestina","family":"Santos","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Joseph M.","family":"Nour","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Fan","family":"Cheng","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Hiroshi","family":"Kuroda","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Tatsuro","family":"Misu","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Ana","family":"Martins-da-Silva","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Gabriele C.","family":"DeLuca","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Angela","family":"Vincent","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Jacqueline","family":"Palace","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Patrick","family":"Waters","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Kazuo","family":"Fujihara","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]},{"given":"Maria Isabel","family":"Leite","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Clinical Neurosciences (M.M.N., E.C., M.W., J.R., J.G., J.K., J.M.N., F.C., G.C.D., A.V., J.P., P.W., M.I.L.), John Radcliffe Hospital, University of Oxford, UK; Departments of Neurology (I.N., Y.T., H.K.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Clinical Neurology (F.S.), Hospital de S\u00e3o Marcos, Braga; and Department of Clinical Neurology (A.M.-d.-S., M.E.S.), Hospital Geral Santo..."}]}],"member":"276","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c1deb9"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.249"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-008-0918-7"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0181-5512(07)91363-7"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678847696"},{"key":"e_1_3_7_9_2","first-page":"1372","article-title":"A woman with acute myelopathy in pregnancy: case outcome","volume":"339","author":"Reuss R","year":"2009","unstructured":"Reuss R, Rommer P, Bruck W, Paul F, Bolz M. A woman with acute myelopathy in pregnancy: case outcome. BMJ 2009;339:1372\u20131373.","journal-title":"BMJ"},{"key":"e_1_3_7_10_2","first-page":"813","article-title":"Down-regulation of aquaporin 4 in human placenta throughout pregnancy","volume":"21","author":"De Falco M","year":"2007","unstructured":"De Falco M, Cobellis L, Torella M, et al.. Down-regulation of aquaporin 4 in human placenta throughout pregnancy. In Vivo 2007;21:813\u2013817.","journal-title":"In Vivo"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301483"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824c466f"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318250d812"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7031-y"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318248dec1"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm062"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f3676"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12494"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6698.541"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70133-3"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dd445b"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.775"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027412"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31825644ff"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a82621"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fd62bb"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510394610"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00240110"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws109"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq350"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305572"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.20"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2012.01260.x"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2004.02.012"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21663"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2014-000020"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2006.05.003"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-7-15"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000428"}],"container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.0000000000002208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T12:54:04Z","timestamp":1711630444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.0000000000002208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,5]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,5]]}},"alternative-id":["10.1212\/WNL.0000000000002208"],"URL":"https:\/\/doi.org\/10.1212\/wnl.0000000000002208","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,5]]},"assertion":[{"value":"2014-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}