{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:18:35Z","timestamp":1786123115745,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1213\/01.ane.0000198657.76705.38","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T04:06:41Z","timestamp":1142568401000},"page":"1114-1120","source":"Crossref","is-referenced-by-count":8,"title":["Modulation of Gamma-Aminobutyric AcidA Receptor Function by Thiopental in the Rat Spinal Dorsal Horn Neurons"],"prefix":"10.1213","volume":"102","author":[{"given":"Chuan-Xiu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Qing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Le","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-24-20210902","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/00000542-199403000-00017","article-title":"Anesthetic potency is not altered after hypothermic spinal cord transection in rats.","volume":"80","author":"Rampil","year":"1994","journal-title":"Anesthesiology"},{"key":"R2-24-20210902","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0306-9877(97)90028-1","article-title":"The relationship among brain, spinal cord and anesthetic requirements.","volume":"48","author":"Antognini","year":"1997","journal-title":"Med Hypotheses"},{"key":"R3-24-20210902","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/bja\/aef158","article-title":"In vitro networks: subcortical mechanisms of anaesthetic action.","volume":"89","author":"Kendig","year":"2002","journal-title":"Br J Anaesth"},{"key":"R4-24-20210902","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/367607a0","article-title":"Molecular and cellular mechanisms of general anaesthesia.","volume":"367","author":"Franks","year":"1994","journal-title":"Nature"},{"key":"R5-24-20210902","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.bjp.0702744","article-title":"Stereoselective interaction of thiopentone enantiomers with the GABA(A) receptor.","volume":"128","author":"Cordato","year":"1999","journal-title":"Br J Pharmacol"},{"key":"R6-24-20210902","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/00000542-200204000-00016","article-title":"Selective synaptic actions of thiopental and its enantiomers.","volume":"96","author":"Dickinson","year":"2002","journal-title":"Anesthesiology"},{"key":"R7-24-20210902","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00000542-199602000-00021","article-title":"Quantitation of depth of thiopental anesthesia in the rat.","volume":"84","author":"Gustafsson","year":"1996","journal-title":"Anesthesiology"},{"key":"R8-24-20210902","doi-asserted-by":"crossref","first-page":"41369","DOI":"10.1074\/jbc.M206768200","article-title":"The general anesthetic pentobarbital slows desensitization and deactivation of the glycine receptor in the rat spinal dorsal horn neurons.","volume":"277","author":"Lu","year":"2002","journal-title":"J Biol Chem"},{"key":"R9-24-20210902","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0165-0270(01)00404-6","article-title":"A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons.","volume":"108","author":"Wu","year":"2001","journal-title":"J Neurosci Methods"},{"key":"R10-24-20210902","doi-asserted-by":"crossref","first-page":"38637","DOI":"10.1074\/jbc.M303735200","article-title":"Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons.","volume":"278","author":"Li","year":"2003","journal-title":"J Biol Chem"},{"key":"R11-24-20210902","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nn913","article-title":"The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway.","volume":"5","author":"Nelson","year":"2002","journal-title":"Nat Neurosci"},{"key":"R12-24-20210902","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/00000542-200204000-00028","article-title":"Does the immobilizing effect of thiopental in brain exceed that of halothane?","volume":"96","author":"Antognini","year":"2002","journal-title":"Anesthesiology"},{"key":"R13-24-20210902","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3959(01)00345-1","article-title":"Reversible analgesia, atonia, and loss of consciousness on bilateral intracerebral microinjection of pentobarbital.","volume":"94","author":"Devor","year":"2001","journal-title":"Pain"},{"key":"R14-24-20210902","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1034\/j.1399-6576.2001.045007823.x","article-title":"Thiopental directly depresses lumbar dorsal horn neuronal responses to noxious mechanical stimulation in goats.","volume":"45","author":"Sudo","year":"2001","journal-title":"Acta Anaesthesiol Scand"},{"key":"R15-24-20210902","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1097\/00000542-199212000-00016","article-title":"Propofol and barbiturate depression of spinal nociceptive neurotransmission.","volume":"77","author":"Jewett","year":"1992","journal-title":"Anesthesiology"},{"key":"R16-24-20210902","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1213\/00000539-200210000-00021","article-title":"The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat.","volume":"95","author":"Dong","year":"2002","journal-title":"Anesth Analg"},{"key":"R17-24-20210902","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0006-8993(02)03274-2","article-title":"Kinetics of etomidate actions on GABA(A) receptors in the rat spinal dorsal horn neurons.","volume":"953","author":"Zhang","year":"2002","journal-title":"Brain Res"},{"key":"R18-24-20210902","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1984.sp015495","article-title":"Chloride current induced by injection of calcium into Xenopus oocytes.","volume":"357","author":"Miledi","year":"1984","journal-title":"J Physiol (Lond)"},{"key":"R19-24-20210902","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neulet.2003.09.025","article-title":"Effects of pentobarbital on GABA-activated currents in acutely-isolated rat dentate gyrus granule neurons.","volume":"353","author":"Lim","year":"2003","journal-title":"Neurosci Lett"},{"key":"R20-24-20210902","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1124\/jpet.102.043273","article-title":"Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neurons.","volume":"304","author":"Kitamura","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"R21-24-20210902","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/bja\/81.6.932","article-title":"Differential inhibitory effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels and NMDA receptors in rat hippocampal slices.","volume":"81","author":"Zhan","year":"1998","journal-title":"Br J Anaesth"},{"key":"R22-24-20210902","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1152\/jn.1998.79.1.240","article-title":"Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents.","volume":"79","author":"Todorovic","year":"1998","journal-title":"J Neurophysiol"},{"key":"R23-24-20210902","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3959(02)00074-X","article-title":"Modulation of inhibitory synaptic activity by a non-alpha4beta2, non-alpha7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord.","volume":"101","author":"Takeda","year":"2003","journal-title":"Pain"},{"key":"R24-24-20210902","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1097\/00000539-200104000-00026","article-title":"Thiopental is a competitive inhibitor at the human alpha7 nicotinic acetylcholine receptor.","volume":"92","author":"Coates","year":"2001","journal-title":"Anesth Analg"},{"key":"R25-24-20210902","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1097\/00000542-200005000-00033","article-title":"Intravenous anesthetics differentially modulate ligand-gated ion channels.","volume":"92","author":"Flood","year":"2000","journal-title":"Anesthesiology"}],"container-title":["Anesthesia &amp; Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/01.ane.0000198657.76705.38","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:06:55Z","timestamp":1786111615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-200604000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.1213\/01.ane.0000198657.76705.38","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}