{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:22:21Z","timestamp":1786123341781,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1213\/01.ane.0000278641.90190.8d","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T18:05:55Z","timestamp":1236189955000},"page":"1086-1093","source":"Crossref","is-referenced-by-count":14,"title":["Intravenous Infusion of Dexmedetomidine Can Prevent the Degeneration of Spinal Ventral Neurons Induced by Intrathecal Morphine After a Noninjurious Interval of Spinal Cord Ischemia in Rats"],"prefix":"10.1213","volume":"105","author":[{"given":"Manabu","family":"Kakinohana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Oshiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Saikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Higa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Davison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Marsala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Sugahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-32-20210902","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S1053-0770(96)80275-8","article-title":"High-dose intrathecal morphine for thoracoabdominal aneurysm repair.","volume":"10","author":"Chaney","year":"1996","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R2-32-20210902","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/00000542-200304000-00012","article-title":"Neuraxial morphine may trigger transient spasticity after a non-injurious interval of spinal cord ischemia: a clinical and experimental study.","volume":"98","author":"Kakinohana","year":"2003","journal-title":"Anesthesiology"},{"key":"R3-32-20210902","first-page":"769","article-title":"Intrathecal administration of morphine, but not small dose, induced spastic paraparesis after a noninjurious interval of aortic occlusion in rats.","volume":"96","author":"Kakinohana","year":"2003","journal-title":"Anesth Analg"},{"key":"R4-32-20210902","first-page":"51","article-title":"Repetitive intrathecal administration of morphine induces irreversible paraplegia after non-injurious interval of spinal cord ischemia in the rat.","volume":"54","author":"Fuchigami","year":"1999","journal-title":"Biologia"},{"key":"R5-32-20210902","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1043-0679(98)80006-3","article-title":"Multifactoral nature of spinal cord circulation.","volume":"10","author":"Acher","year":"1998","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"R6-32-20210902","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1213\/00000539-199212000-00014","article-title":"Alfentanil-induced hypermetabolism, seizure, and histopathology in rat brain.","volume":"75","author":"Kofke","year":"1992","journal-title":"Anesth Analg"},{"key":"R7-32-20210902","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1213\/00000539-199612000-00029","article-title":"Opioid neurotoxicity: fentanyl dose response effects in rats.","volume":"83","author":"Kofke","year":"1996","journal-title":"Anesth Analg"},{"key":"R8-32-20210902","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/00000539-200205000-00033","article-title":"The neuropathologic effects in rats and neurometabolic effect in humans of large-dose remifentanil.","volume":"94","author":"Kofke","year":"2002","journal-title":"Anesth Analg"},{"key":"R9-32-20210902","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/01616412.2000.11740748","article-title":"Opioid neurotoxicity: role of neurotoransmitter system.","volume":"22","author":"Kofke","year":"2000","journal-title":"Neurol Res"},{"key":"R10-32-20210902","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1213\/01.ANE.0000142123.63543.A6","article-title":"The activation of spinal N-methyl-d-aspartate receptors may contribute to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurous interval of spinal cord ischaemia.","volume":"100","author":"Kakinohana","year":"2005","journal-title":"Anesth Analg"},{"key":"R11-32-20210902","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1097\/00000542-200011000-00030","article-title":"Clinical uses of alpha2-adrenergic agonists.","volume":"93","author":"Kamibayashi","year":"2000","journal-title":"Anesthesiology"},{"key":"R12-32-20210902","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00000539-200003000-00035","article-title":"Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions.","volume":"90","author":"Hall","year":"2000","journal-title":"Anesth Analg"},{"key":"R13-32-20210902","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1213\/01.ANE.0000093225.39866.75","article-title":"The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatients surgery.","volume":"98","author":"Arain","year":"2004","journal-title":"Anesth Analg"},{"key":"R14-32-20210902","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00000542-199708000-00025","article-title":"Neuroprotective effects of dexmedetomidine in the geribil hippocampus following transient global ischemia.","volume":"87","author":"Kuhmonen","year":"1997","journal-title":"Anesthesiology"},{"key":"R15-32-20210902","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000542-199308000-00016","article-title":"Neuroprotection by the \u03b12-adrenoreceptor agonist dexmedetomidine in a gocal model of cerebral ischemia.","volume":"79","author":"Maier","year":"1993","journal-title":"Anesthesiology"},{"key":"R16-32-20210902","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00000542-199108000-00022","article-title":"Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat.","volume":"75","author":"Hoffman","year":"1991","journal-title":"Anesthesiology"},{"key":"R17-32-20210902","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0028-3908(96)84639-9","article-title":"Alpha 2-adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia.","volume":"35","author":"Bickler","year":"1996","journal-title":"Neuropharmacology"},{"key":"R18-32-20210902","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/00000542-199609000-00014","article-title":"Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices.","volume":"85","author":"Talke","year":"1996","journal-title":"Anesthesiology"},{"key":"R19-32-20210902","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0031-9384(76)90029-9","article-title":"Chronic catheterization of the spinal subarachnoid space.","volume":"17","author":"Yaksh","year":"1976","journal-title":"Physiol Behav"},{"key":"R20-32-20210902","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1161\/01.STR.27.10.1850","article-title":"Effect of proximal arterial perfusion pressure on function, spinal cord blood flow, and histopathologic changes after increasing intervals of aortic occlusion in the rat.","volume":"27","author":"Taira","year":"1996","journal-title":"Stroke"},{"key":"R21-32-20210902","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/00000542-199903000-00022","article-title":"The effect of graded postischemic spinal cord hypothermia on neurological outcome and histopathology after transient spinal ischaemia in rat.","volume":"90","author":"Kakinohana","year":"1999","journal-title":"Anesthesiology"},{"key":"R22-32-20210902","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1213\/00000539-199701000-00025","article-title":"Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram.","volume":"84","author":"Dowlatshahi","year":"1997","journal-title":"Anesth Analg"},{"key":"R23-32-20210902","first-page":"253","article-title":"Endogeneous opioid system activity following temporary focal cerebral ischaemia.","volume":"60","author":"Ting","year":"1994","journal-title":"Acta Neurochir Suppl"},{"key":"R24-32-20210902","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF01990015","article-title":"The depression of spinal inhibition by morphine.","volume":"1","author":"Curtis","year":"1969","journal-title":"Agents Actions"},{"key":"R25-32-20210902","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0006-8993(82)90038-5","article-title":"Opiate alkaloids antagonized postsynaptic glycine and GABA responces: correlation with convulsant action.","volume":"236","author":"Werz","year":"1982","journal-title":"Brain Res"},{"key":"R26-32-20210902","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1523\/JNEUROSCI.07-02-00369.1987","article-title":"Ionic dependence of glutamate neurotoxicity.","volume":"7","author":"Choi","year":"1987","journal-title":"J Neurosci"},{"key":"R27-32-20210902","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0006-8993(91)91716-E","article-title":"Neurotoxic activation of glutamate receptors induces an extended, neuronal depolarization in cultured hippocampal neurons.","volume":"566","author":"Sombati","year":"1991","journal-title":"Brain Res"},{"key":"R28-32-20210902","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0014-2999(02)01664-3","article-title":"Involvement of imidazoline receptors in the centrally acting muscle-relazant effects of tizanidine.","volume":"445","author":"Honda","year":"2002","journal-title":"Eur J Pharmacol"}],"container-title":["Anesthesia &amp; Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/01.ane.0000278641.90190.8d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:17:44Z","timestamp":1786112264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-200710000-00032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1213\/01.ane.0000278641.90190.8d","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}