{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:23:38Z","timestamp":1786123418048,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>This study\u2019s purpose was to assess whether larger volumes of reinfused unwashed shed autologous blood (SAB) were associated with adverse events within 30 days for patients undergoing open thoracoabdominal aortic aneurysm (TAAA) repair. During TAAA repair, our institution uses a system wherein SAB is filtered, but not washed or centrifuged, and then returned to the patient via a rapid-infusion device. By reinfusing SAB, the system preserves the patient\u2019s autologous whole blood and may reduce the number of allogenic transfusions required during TAAA repair, but the end-organ effects of reinfusing unwashed SAB have not been extensively evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Using a prospectively maintained database, we retrospectively analyzed data from 972 consecutive patients who underwent open TAAA repair at our institution from 2007 to 2021 and who received SAB. Multivariable logistic regressions were performed to assess whether SAB reinfusion volume was associated with a composite outcome of adverse events, as well as operative mortality, a composite of cardiac complications, a composite of pulmonary complications, or persistent paraplegia, stroke, or postoperative renal failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among the cohort of 972 patients, the median volume of reinfused SAB was 4159 mL (quartile1\u2013quartile3 [Q1\u2013Q3]: 2524\u20136790 mL). Greater reinfusion volumes of unwashed SAB were not associated with greater odds of composite adverse events (odds ratio [OR], 1.02 per 1000 mL increase, 97.5% confidence interval [CI], 0.94\u20131.09,\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      .624), nor with any individual outcome\u2014operative mortality (OR, 1.02 per 1000 mL increase, 97.5% CI, 0.93\u20131.12,\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      .617), a composite of cardiac complications (OR, 0.98 per 1000 mL increase, 97.5% CI, 0.93\u20131.04,\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      .447), a composite of pulmonary complications (OR, 1.00 per 1000 mL increase, 97.5% CI, 0.94\u20131.06,\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      .963), renal failure necessitating hemodialysis (OR, 1.01 per 1000 mL increase, 97.5% CI, 0.92\u20131.11,\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      .821), persistent paraplegia (OR, 0.97 per 1000 mL increase, 97.5% CI, 0.84\u20131.13,\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      .676), persistent stroke (OR, 0.85 per 1000 mL increase, 97.5% CI, 0.70\u20131.04,\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      .070), or reoperation to control bleeding (OR, 0.99, 97.5% CI, 0.87\u20131.13,\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      .900)\u2014when adjusted for confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>For patients undergoing open TAAA repair, larger reinfusion volumes of unwashed SAB were not associated with greater odds of major early postoperative complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1213\/ane.0000000000007103","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T12:14:03Z","timestamp":1723551243000},"page":"527-536","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Direct Reinfusion of Unwashed Shed Autologous Blood During Thoracoabdominal Aortic Aneurysm Repair: A Retrospective Analysis"],"prefix":"10.1213","volume":"140","author":[{"given":"Thomas R.","family":"Powell","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Division of Cardiovascular Anesthesia and Critical Care Medicine, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Cardiovascular Anesthesiology, The Texas Heart Institute, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Division of Cardiovascular Anesthesia and Critical Care Medicine, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Cardiovascular Anesthesiology, The Texas Heart Institute, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Y.","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Tolpin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Division of Cardiovascular Anesthesia and Critical Care Medicine, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Cardiovascular Anesthesiology, The Texas Heart Institute, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen A.","family":"Staggers","sequence":"additional","affiliation":[{"name":"Department of Baylor College of Medicine, Institute for Clinical and Translational Research, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Anton","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Division of Cardiovascular Anesthesia and Critical Care Medicine, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Cardiovascular Anesthesiology, The Texas Heart Institute, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"LeMaire","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas"},{"name":"Research Institute and Heart & Vascular Institute, Geisinger, Danville, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Coselli","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Michael E. 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