{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:12:21Z","timestamp":1790763141337,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1213\/ane.0b013e3181904571","type":"journal-article","created":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T03:21:18Z","timestamp":1231903278000},"page":"484-490","source":"Crossref","is-referenced-by-count":37,"title":["Anesthetics Discriminate Between Tonic and Phasic \u03b3-Aminobutyric Acid Receptors on Hippocampal CA1 Neurons"],"prefix":"10.1213","volume":"108","author":[{"given":"Mark C.","family":"Bieda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Bruce","family":"MacIver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20210902","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/00000542-199304000-00020","article-title":"The role of the GABAA receptor\/chloride channel complex in anesthesia.","volume":"78","author":"Tanelian","year":"1993","journal-title":"Anesthesiology"},{"key":"R2-16-20210902","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2210-7-2","article-title":"Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions.","volume":"7","author":"Zeller","year":"2007","journal-title":"BMC Pharm"},{"key":"R3-16-20210902","doi-asserted-by":"crossref","first-page":"10650","DOI":"10.1523\/JNEUROSCI.23-33-10650.2003","article-title":"Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus.","volume":"23","author":"Wei","year":"2003","journal-title":"J Neurosci"},{"key":"R4-16-20210902","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.alcohol.2007.03.009","article-title":"A new meaning for \u201cGin & Tonic\u201d: tonic inhibition as the target for ethanol action in the brain.","volume":"41","author":"Mody","year":"2007","journal-title":"Alcohol"},{"key":"R5-16-20210902","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tins.2004.07.002","article-title":"Diversity of inhibitory neurotransmission through GABA(A) receptors.","volume":"27","author":"Mody","year":"2004","journal-title":"Trends Neurosci"},{"key":"R6-16-20210902","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1152\/jn.01199.2005","article-title":"Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.","volume":"96","author":"Prenosil","year":"2006","journal-title":"J Neurophys"},{"key":"R7-16-20210902","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1523\/JNEUROSCI.20-03-00937.2000","article-title":"Kinetic differences between synaptic and extrasynaptic GABA(A) receptors in CA1 pyramidal cells.","volume":"20","author":"Banks","year":"2000","journal-title":"J Neurosci"},{"key":"R8-16-20210902","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature02615","article-title":"Routing of spike series by dynamic circuits in the hippocampus.","volume":"429","author":"Pouille","year":"2004","journal-title":"Nature"},{"key":"R9-16-20210902","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0896-6273(93)90310-N","article-title":"Physiological evidence for two distinct GABAA responses in rat hippocampus.","volume":"10","author":"Pearce","year":"1993","journal-title":"Neuron"},{"key":"R10-16-20210902","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1152\/jn.00700.2002","article-title":"GABA(A) receptor beta3 subunit deletion decreases alpha2\/3 subunits and IPSC duration.","volume":"89","author":"Ramadan","year":"2003","journal-title":"J Neurophys"},{"key":"R11-16-20210902","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0896-6273(00)80907-1","article-title":"Interactions between distinct GABA(A) circuits in hippocampus.","volume":"25","author":"Banks","year":"2000","journal-title":"Neuron"},{"key":"R12-16-20210902","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuropharm.2006.10.009","article-title":"Gaboxadol, a selective extrasynaptic GABA(A) agonist, does not generalise to other sleep-enhancing drugs: a rat drug discrimination study.","volume":"52","author":"McDonald","year":"2007","journal-title":"Neuropharmacology"},{"key":"R13-16-20210902","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.5664\/jcsm.26526","article-title":"Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs.","volume":"2","author":"Orser","year":"2006","journal-title":"JCSM"},{"key":"R14-16-20210902","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1073\/pnas.0307231101","article-title":"Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.","volume":"101","author":"Caraiscos","year":"2004","journal-title":"PNAS"},{"key":"R15-16-20210902","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1124\/mol.59.4.814","article-title":"Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.","volume":"59","author":"Bai","year":"2001","journal-title":"Mol Pharm"},{"key":"R16-16-20210902","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1152\/jn.00223.2004","article-title":"Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability.","volume":"92","author":"Bieda","year":"2004","journal-title":"J Neurophys"},{"key":"R17-16-20210902","doi-asserted-by":"crossref","first-page":"8454","DOI":"10.1523\/JNEUROSCI.2063-04.2004","article-title":"Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane.","volume":"24","author":"Caraiscos","year":"2004","journal-title":"J Neurosci"},{"key":"R18-16-20210902","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1523\/JNEUROSCI.2040-04.2004","article-title":"Low ethanol concentrations selectively augment the tonic inhibition mediated by {delta} subunit-containing GABAA receptors in hippocampal neurons.","volume":"24","author":"Wei","year":"2004","journal-title":"J Neurosci"},{"key":"R19-16-20210902","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1523\/JNEUROSCI.3362-05.2005","article-title":"GABAA receptor-mediated tonic inhibition in thalamic neurons.","volume":"25","author":"Cope","year":"2005","journal-title":"J Neurosci"},{"key":"R20-16-20210902","doi-asserted-by":"crossref","first-page":"15230","DOI":"10.1073\/pnas.0604304103","article-title":"GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol.","volume":"103","author":"Chandra","year":"2006","journal-title":"PNAS"},{"key":"R21-16-20210902","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1124\/mol.106.028597","article-title":"Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating.","volume":"71","author":"McCartney","year":"2007","journal-title":"Mol Pharm"},{"key":"R22-16-20210902","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0165-0270(98)00029-6","article-title":"Concentration measures of volatile anesthetics in the aqueous phase using calcium sensitive electrodes.","volume":"81","author":"Hagan","year":"1998","journal-title":"J Neurosci Methods"},{"key":"R23-16-20210902","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2202-5-52","article-title":"Multiple synaptic and membrane sites of anesthetic action in the CA1 region of rat hippocampal slices.","volume":"5","author":"Pittson","year":"2004","journal-title":"BMC Neurosci"},{"key":"R24-16-20210902","first-page":"503","article-title":"Emerging molecular mechanisms of general anesthetic action.","volume":"26","author":"Hemmings","year":"2005","journal-title":"TIPS"},{"key":"R25-16-20210902","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1124\/jpet.107.134569","article-title":"Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus.","volume":"324","author":"Jia","year":"2008","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Anesthesia &amp; Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ane.0b013e3181904571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:17:23Z","timestamp":1786112243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-200902000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e3181904571","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1159872.621300","asserted-by":"object"}]},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}