{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:20:40Z","timestamp":1786123240613,"version":"build-2736575974"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1213\/ane.0b013e31819367ba","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T17:23:48Z","timestamp":1242926628000},"page":"1163-1168","source":"Crossref","is-referenced-by-count":39,"title":["Intralipid Infusion Diminishes Return of Spontaneous Circulation After Hypoxic Cardiac Arrest in Rabbits"],"prefix":"10.1213","volume":"108","author":[{"given":"Martyn","family":"Harvey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Cave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Kazemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-21-20210902","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/00000542-199804000-00028","article-title":"Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats.","volume":"88","author":"Weinberg","year":"1998","journal-title":"Anesthesiology"},{"key":"R2-21-20210902","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1053\/rapm.2003.50041","article-title":"Lipid emulsion infusion rescues dogs from bupivacaine induced cardiac toxicity.","volume":"28","author":"Weinberg","year":"2003","journal-title":"Reg Anesth Pain Med"},{"key":"R3-21-20210902","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00000542-200607000-00033","article-title":"Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest.","volume":"105","author":"Rosenblatt","year":"2006","journal-title":"Anesthesiology"},{"key":"R4-21-20210902","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1365-2044.2006.04740.x","article-title":"Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion.","volume":"61","author":"Litz","year":"2006","journal-title":"Anesthesia"},{"key":"R5-21-20210902","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/00115550-200803000-00014","article-title":"Early intralipid may have prevented bupivacaine associated cardiac arrest.","volume":"33","author":"McCutchen","year":"2008","journal-title":"Reg Anaesth Pain Med"},{"key":"R6-21-20210902","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2044.2007.05065.x","article-title":"Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid.","volume":"62","author":"Foxall","year":"2007","journal-title":"Anaesthesia"},{"key":"R7-21-20210902","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1213\/01.ane.0000281434.80883.88","article-title":"Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block.","volume":"106","author":"Warren","year":"2008","journal-title":"Anesth Analg"},{"key":"R8-21-20210902","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1213\/01.ane.0000286176.55971.f0","article-title":"Successful resuscitation after ropivacaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child.","volume":"106","author":"Ludot","year":"2008","journal-title":"Anesth Analg"},{"key":"R9-21-20210902","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.annemergmed.2006.07.016","article-title":"Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity.","volume":"49","author":"Harvey","year":"2007","journal-title":"Ann Emerg Med"},{"key":"R10-21-20210902","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1197\/j.aem.2005.08.016","article-title":"Intralipid prolongs survival in a rat model of verapamil toxicity.","volume":"13","author":"Tebbutt","year":"2006","journal-title":"Acad Emerg Med"},{"key":"R11-21-20210902","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1197\/j.aem.2006.10.094","article-title":"Hemodynamic effects of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium, and saline.","volume":"14","author":"Bania","year":"2007","journal-title":"Acad Emerg Med"},{"key":"R12-21-20210902","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/BF03161005","article-title":"The role of fat emulsion therapy in a rodent model of propranolol toxicity: a preliminary study.","volume":"2","author":"Cave","year":"2006","journal-title":"J Med Toxicol"},{"key":"R13-21-20210902","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03160958","article-title":"Intralipid infusion ameliorates propranolol induced hypotension in rabbits.","volume":"4","author":"Harvey","year":"2008","journal-title":"J Med Toxicol"},{"key":"R14-21-20210902","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.annemergmed.2007.06.004","article-title":"Use of Intralipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine.","volume":"51","author":"Sirianni","year":"2008","journal-title":"Ann Emerg Med"},{"key":"R15-21-20210902","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0033-0620(81)90019-0","article-title":"Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart.","volume":"23","author":"Liedtke","year":"1981","journal-title":"Prog Cardiovacs Dis"},{"key":"R16-21-20210902","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11010-006-2518-9","article-title":"Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts.","volume":"283","author":"Gambert","year":"2006","journal-title":"Mol Cell Biochem"},{"key":"R17-21-20210902","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01907958","article-title":"The effect of elevated arterial free fatty acid concentrations on hemodynamics and myocardial metabolism and blood flow during ischemia.","volume":"76","author":"Prinzen","year":"1981","journal-title":"Basic Res Cardiol"},{"key":"R18-21-20210902","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1748-1716.1995.tb09847.x","article-title":"Intravenous lipid infusion results in myocardial lipid droplet accumulation combined with reduced myocardial performance in heparinized rabbits.","volume":"153","author":"Hexeberg","year":"1995","journal-title":"Acta Physiol Scand"},{"key":"R19-21-20210902","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/00003246-198806000-00004","article-title":"Cardiopulmonary effects of intralipid infusion in critically ill patients.","volume":"16","author":"Venus","year":"1988","journal-title":"Crit Care Med"},{"key":"R20-21-20210902","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0140-6736(83)90388-4","article-title":"Relation between plasma free fatty acids and arrhythmias within the first twelve hours of acute myocardial infarction.","volume":"2","author":"Tansey","year":"1983","journal-title":"Lancet"},{"key":"R21-21-20210902","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00000441-199907000-00002","article-title":"Fatty acid oxidation in the reperfused ischemic heart.","volume":"318","author":"Kantor","year":"1999","journal-title":"Am J Med Sci"},{"key":"R22-21-20210902","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/cvr\/20.4.256","article-title":"Exogenous substrate preference of the post-ischemic myocardium.","volume":"20","author":"Mickle","year":"1986","journal-title":"Cardiovasc Res"},{"key":"R23-21-20210902","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1024734605562","article-title":"Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion.","volume":"249","author":"Assum","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"R24-21-20210902","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1152\/physrev.1990.70.2.247","article-title":"Ventricular energetics.","volume":"70","author":"Suga","year":"1990","journal-title":"Physiol Rev"},{"key":"R25-21-20210902","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0006-3002(62)90232-9","article-title":"Uncoupling activity of long-chain fatty acids.","volume":"62","author":"Borst","year":"1962","journal-title":"Biochem Biophys Acta"},{"key":"R26-21-20210902","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0022-2828(92)91099-Q","article-title":"Triacylglyerol metabolism in hypoxic glucose deprived rat cardiomyocytes.","volume":"24","author":"Myrmel","year":"1992","journal-title":"J Mol Cell Cardiol"},{"key":"R27-21-20210902","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/01.CIR.58.3.484","article-title":"The effect of free fatty acids on myocardial oxygen consumption during atrial pacing and catecholamine infusion in man.","volume":"58","author":"Simonsen","year":"1978","journal-title":"Circulation"},{"key":"R28-21-20210902","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(94)90939-3","article-title":"Effects of glucose and fatty acids on myocardial ischemia and arrhythmias.","volume":"343","author":"Oliver","year":"1994","journal-title":"Lancet"},{"key":"R29-21-20210902","first-page":"32","article-title":"Optimizing cardiac energy metabolism: a new approach to treating ischemia heart disease.","volume":"1","author":"Lopaschuk","year":"1999","journal-title":"Eur Heart J"},{"key":"R30-21-20210902","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/qjmed\/hcl084","article-title":"Sudden cardiac death: the lost fatty acid hypothesis.","volume":"99","author":"Oliver","year":"2006","journal-title":"Q J Med"},{"key":"R31-21-20210902","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(70)92412-8","article-title":"A metabolic cause for arrhythmias during acute myocardial hypoxia.","volume":"1","author":"Kurien","year":"1970","journal-title":"Lancet"},{"key":"R32-21-20210902","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11010-006-2518-9","article-title":"Adverse effects of free fatty acids associated with increased oxidative stress in postischemic isolated rat hearts.","volume":"283","author":"Gambert","year":"2006","journal-title":"Mol Cell Biochem"},{"key":"R33-21-20210902","first-page":"741","article-title":"Long-chain acylcarnitine increases intracellular Ca++ and induces after depolarization in adult ventricular myocytes.","volume":"86","author":"Fischbach","year":"1992","journal-title":"Circulation"},{"key":"R34-21-20210902","doi-asserted-by":"crossref","first-page":"11396","DOI":"10.1016\/S0021-9258(17)39040-3","article-title":"Identification of NaK-ATPase inhibitors in human plasma as nonesterified fatty acids and lysophospholipids.","volume":"260","author":"Kelly","year":"1985","journal-title":"J Biol Chem"},{"key":"R35-21-20210902","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0008-6363(96)00165-4","article-title":"Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs.","volume":"32","author":"Van de Velde","year":"1996","journal-title":"Cardiovasc Res"},{"key":"R36-21-20210902","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0008-6363(00)00151-6","article-title":"Effects of lipids on the functional and metabolic recovery from global myocardial stunning in isolated rabbit hearts.","volume":"48","author":"Van der Velde","year":"2000","journal-title":"Cardiovasc Res"},{"key":"R37-21-20210902","first-page":"284","article-title":"10% soybean oil emulsion as a myocardial energy substrate after ischemic arrest.","volume":"28","author":"Jones","year":"1977","journal-title":"Surg Forum"},{"key":"R38-21-20210902","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1213\/01.ane.0000248220.01320.58","article-title":"The effects of lipid on myocardial function and bioenergetics in L-bupivacaine toxicity in the isolated rat heart.","volume":"104","author":"Stehr","year":"2007","journal-title":"Anesth Analg"},{"key":"R39-21-20210902","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ajem.2006.08.022","article-title":"Epinephrine but not vasopressin improves survival rates in an adult rabbit model of asphyxial cardiac arrest.","volume":"25","author":"Chen","year":"2007","journal-title":"Am J Emerg Med"},{"key":"R40-21-20210902","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/107424840501000205","article-title":"Carvedilol mitigates adverse effects of epinephrine during cardiopulmonary resuscitation.","volume":"10","author":"Huang","year":"2005","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"R41-21-20210902","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1161\/01.CIR.92.10.3089","article-title":"Epinephrine increases the severity of postresuscitation myocardial dysfunction.","volume":"92","author":"Tang","year":"1995","journal-title":"Circulation"},{"key":"R42-21-20210902","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/jama.1960.03030070020004","article-title":"Oxygen: the antidote for systemic toxic reactions from local anesthetic drugs.","volume":"174","author":"Moore","year":"1960","journal-title":"JAMA"},{"key":"R43-21-20210902","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1213\/01.ane.0000278866.01963.79","article-title":"A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine.","volume":"106","author":"Mayr","year":"2008","journal-title":"Anesth Analg"}],"container-title":["Anesthesia & Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ane.0b013e31819367ba","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:11:56Z","timestamp":1786111916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-200904000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e31819367ba","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}