{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:45:31Z","timestamp":1792658731825,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1213\/ane.0b013e318193e934","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T17:23:48Z","timestamp":1242926628000},"page":"1076-1082","source":"Crossref","is-referenced-by-count":28,"title":["Transient Metabolic Alkalosis During Early Reperfusion Abolishes Helium Preconditioning Against Myocardial Infarction: Restoration of Cardioprotection by Cyclosporin A in Rabbits"],"prefix":"10.1213","volume":"108","author":[{"given":"Paul S.","family":"Pagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Krolikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20210902","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00000542-200607000-00029","article-title":"Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon.","volume":"105","author":"Preckel","year":"2006","journal-title":"Anesthesiology"},{"key":"R2-5-20210902","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1213\/01.ane.0000278083.31991.36","article-title":"Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo.","volume":"105","author":"Pagel","year":"2007","journal-title":"Anesth Analg"},{"key":"R3-5-20210902","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/01.CCM.0B013E3181611F8A6","article-title":"The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury.","volume":"36","author":"Coburn","year":"2008","journal-title":"Crit Care Med"},{"key":"R4-5-20210902","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1213\/ane.0b013e3181815995","article-title":"The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits.","volume":"107","author":"Pagel","year":"2008","journal-title":"Anesth Analg"},{"key":"R5-5-20210902","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1213\/ane.0b013e3181815b84","article-title":"Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition.","volume":"107","author":"Pagel","year":"2008","journal-title":"Anesth Analg"},{"key":"R6-5-20210902","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1053\/j.jvca.2008.04.005","article-title":"Reactive oxygen species and mitochondrial KATP channels mediate helium-induced preconditioning against myocardial infarction in vivo.","volume":"22","author":"Pagel","year":"2008","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R7-5-20210902","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cardiores.2006.01.017","article-title":"Survival kinases in ischemic preconditioning and postconditioning.","volume":"70","author":"Hausenloy","year":"2006","journal-title":"Cardiovasc Res"},{"key":"R8-5-20210902","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1053\/j.jvca.2008.03.005","article-title":"Postconditioning by volatile anesthetics: salvaging ischemic myocardium at reperfusion by activation of prosurvival signaling.","volume":"22","author":"Pagel","year":"2008","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R9-5-20210902","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/bj3070093","article-title":"Mitochondrial non-specific pores remain closed during cardiac ischemia but open upon reperfusion.","volume":"307","author":"Griffiths","year":"1995","journal-title":"Biochem J"},{"key":"R10-5-20210902","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF02110643","article-title":"The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal.","volume":"28","author":"Bernardi","year":"1996","journal-title":"J Bioenerg Biomembr"},{"key":"R11-5-20210902","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cardiores.2006.02.024","article-title":"Mitochondrial permeability transition pore and postconditioning.","volume":"70","author":"Gateau-Roesch","year":"2006","journal-title":"Cardiovasc Res"},{"key":"R12-5-20210902","doi-asserted-by":"crossref","first-page":"18558","DOI":"10.1074\/jbc.C500089200","article-title":"Properties of the permeability transition pore in mitochondrial devoid of cyclophilin D.","volume":"280","author":"Basso","year":"2005","journal-title":"J Biol Chem"},{"key":"R13-5-20210902","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role of mitchondrial permeability transition in cell death.","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"R14-5-20210902","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature03317","article-title":"Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death.","volume":"434","author":"Nakagawa","year":"2005","journal-title":"Nature"},{"key":"R15-5-20210902","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1006\/jmcc.1993.1162","article-title":"Protection by cyclosporin A of ischemia\/reperfusion induced damage in isolated rat hearts.","volume":"25","author":"Griffiths","year":"1993","journal-title":"J Mol Cell Cardiol"},{"key":"R16-5-20210902","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.yjmcc.2004.12.001","article-title":"Specific inhibition of mitochondrial permability transition prevents lethal reperfusion injury.","volume":"38","author":"Argaud","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"R17-5-20210902","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/01.CIR.0000151290.04952.3B","article-title":"Postconditioning inhibits mitochondrial permeability transition.","volume":"111","author":"Argaud","year":"2005","journal-title":"Circulation"},{"key":"R18-5-20210902","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cardiores.2003.09.025","article-title":"Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury.","volume":"60","author":"Hausenloy","year":"2003","journal-title":"Cardiovasc Res"},{"key":"R19-5-20210902","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1074\/jbc.M006825200","article-title":"Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.","volume":"276","author":"Di Lisa","year":"2001","journal-title":"J Biol Chem"},{"key":"R20-5-20210902","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1172\/JCI113699","article-title":"Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts.","volume":"82","author":"Kitakaze","year":"1988","journal-title":"J Clin Invest"},{"key":"R21-5-20210902","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1161\/01.RES.74.6.1197","article-title":"Acidemia and hypernatremia enhance postischemic recovery of excitation-contraction coupling.","volume":"74","author":"Harada","year":"1994","journal-title":"Circ Res"},{"key":"R22-5-20210902","first-page":"H2071","article-title":"Temporary acidosis during reperfusion limits myocardial infarct size in dogs.","volume":"272","author":"Kitakaze","year":"1997","journal-title":"Am J Physiol"},{"key":"R23-5-20210902","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1074\/jbc.271.4.2185","article-title":"Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin A-sensitive channel.","volume":"271","author":"Nicolli","year":"1996","journal-title":"J Biol Chem"},{"key":"R24-5-20210902","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1021\/bi00067a039","article-title":"Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH: evidence that the pore open-closed probability is regulated by reversible histidine protonation.","volume":"32","author":"Nicolli","year":"1993","journal-title":"Biochemistry"},{"key":"R25-5-20210902","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1161\/CIRCULATIONAHA.106.675710","article-title":"The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis.","volume":"115","author":"Cohen","year":"2007","journal-title":"Circulation"},{"key":"R26-5-20210902","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1213\/01.ANE.0000181288.13549.28","article-title":"Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: role of mitochondrial KATP channels.","volume":"101","author":"Krolikowski","year":"2005","journal-title":"Anesth Analg"},{"key":"R27-5-20210902","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/bja\/ael153","article-title":"Xenon preconditioning differently regulates p44\/42 MAPK (ERK1\/2) and p46\/54 MAPK (JNK 1\/2 and 3) in vivo.","volume":"97","author":"Weber","year":"2006","journal-title":"Br J Anaesth"},{"key":"R28-5-20210902","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.03.054","article-title":"Upstream signaling of PKC-\u03b5 in xenon-induced pharmacological preconditioning. Implication of mitochondrial KATP channels and PDK-1.","volume":"539","author":"Weber","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"R29-5-20210902","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"key":"R30-5-20210902","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/21218","article-title":"Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.","volume":"399","author":"Fulton","year":"1999","journal-title":"Nature"},{"key":"R31-5-20210902","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1432-1033.1997.00710.x","article-title":"Modulation of the mitochondrial permeability transition by nitric oxide.","volume":"246","author":"Balakirev","year":"1997","journal-title":"Eur J Biochem"},{"key":"R32-5-20210902","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1172\/JCI19906","article-title":"Glycogen sythase kinase-3\u03b2 mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore.","volume":"113","author":"Juhaszova","year":"2004","journal-title":"J Clin Invest"},{"key":"R33-5-20210902","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1092734","article-title":"Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.","volume":"303","author":"Chipuk","year":"2004","journal-title":"Science"},{"key":"R34-5-20210902","doi-asserted-by":"crossref","first-page":"48872","DOI":"10.1074\/jbc.M305870200","article-title":"Glycogen synthase kinase-3\u03b2 (GSK3\u03b2) binds to and promotes the actions of p53.","volume":"278","author":"Watcharasti","year":"2003","journal-title":"J Biol Chem"},{"key":"R36-5-20210902","doi-asserted-by":"crossref","first-page":"C1783","DOI":"10.1152\/ajpcell.1997.273.6.C1783","article-title":"Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes.","volume":"273","author":"Qian","year":"1997","journal-title":"Am J Physiol"},{"key":"R37-5-20210902","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/01.RES.80.5.743","article-title":"Oxygen radicals can induce preconditioning in rabbit hearts.","volume":"80","author":"Tritto","year":"1997","journal-title":"Circ Res"},{"key":"R38-5-20210902","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.bjp.0706063","article-title":"The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-\u03b5 and p38 MAPK.","volume":"144","author":"Weber","year":"2005","journal-title":"Br J Pharmacol"},{"key":"R39-5-20210902","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/cvr\/21.10.737","article-title":"Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction.","volume":"21","author":"Maxwell","year":"1987","journal-title":"Cardiovasc Res"}],"container-title":["Anesthesia &amp; Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ane.0b013e318193e934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:11:53Z","timestamp":1786111913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-200904000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e318193e934","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}