{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T18:30:13Z","timestamp":1786473013412,"version":"build-2736575974"},"reference-count":66,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1213\/ane.0b013e31819e0d3a","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T17:56:14Z","timestamp":1242928574000},"page":"1811-1822","source":"Crossref","is-referenced-by-count":66,"title":["Peripherally Acting Mu-Opioid Receptor Antagonists and Postoperative Ileus: Mechanisms of Action and Clinical Applicability"],"prefix":"10.1213","volume":"108","author":[{"given":"Eugene R.","family":"Viscusi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong J.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Foss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Talon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gay","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20210902","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/j.scrs.2006.01.007","article-title":"Preventive measures to minimize or avoid postoperative ileus.","volume":"16","author":"Kehlet","year":"2005","journal-title":"Semin Colon Rectal Surg"},{"key":"R2-16-20210902","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1053\/cgh.2003.50012","article-title":"Postoperative ileus: etiologies and interventions.","volume":"1","author":"Behm","year":"2003","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R3-16-20210902","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01537233","article-title":"Postoperative ileus.","volume":"35","author":"Livingston","year":"1990","journal-title":"Dig Dis Sci"},{"key":"R4-16-20210902","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/S0002-9610(01)00781-4","article-title":"Review of postoperative ileus.","volume":"182","author":"Kehlet","year":"2001","journal-title":"Am J Surg"},{"key":"R6-16-20210902","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/00000658-199811000-00004","article-title":"Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus.","volume":"228","author":"Kalff","year":"1998","journal-title":"Ann Surg"},{"key":"R7-16-20210902","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1345\/aph.1E615","article-title":"Alvimopan for the management of postoperative ileus.","volume":"39","author":"Leslie","year":"2005","journal-title":"Ann Pharmacother"},{"key":"R10-16-20210902","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neulet.2003.12.004","article-title":"Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humans.","volume":"361","author":"Holzer","year":"2004","journal-title":"Neurosci Lett"},{"key":"R11-16-20210902","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2165\/00003495-200363070-00003","article-title":"Opioid-induced bowel dysfunction: pathophysiology and potential new therapies.","volume":"63","author":"Kurz","year":"2003","journal-title":"Drugs"},{"key":"R12-16-20210902","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1053\/j.scrs.2006.01.005","article-title":"Endogenous opioids and the gastrointestinal tract.","volume":"16","author":"Sanger","year":"2005","journal-title":"Semin Colon Rectal Surg"},{"key":"R13-16-20210902","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1743-3150.2004.00553.x","article-title":"The opioid system in the gastrointestinal tract.","volume":"16","author":"Sternini","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"R14-16-20210902","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0002-9610(02)00866-8","article-title":"Multimodal strategies to improve surgical outcome.","volume":"183","author":"Kehlet","year":"2002","journal-title":"Am J Surg"},{"key":"R15-16-20210902","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1743-3150.2004.00559.x","article-title":"Clinical perspective on postoperative ileus and the effect of opiates.","volume":"16","author":"Delaney","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"R17-16-20210902","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.2146\/ajhp070428","article-title":"Pathogenesis and clinical and economic consequences of postoperative ileus.","volume":"64","author":"Senagore","year":"2007","journal-title":"Am J Health Syst Pharm"},{"key":"R18-16-20210902","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1046\/j.1365-2168.2000.01595.x","article-title":"Postoperative ileus: a preventable event.","volume":"87","author":"Holte","year":"2000","journal-title":"Br J Surg"},{"key":"R19-16-20210902","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1046\/j.0007-1323.2001.02044.x","article-title":"Accelerated postoperative recovery programme after colonic resection improves physical performance, pulmonary function and body composition.","volume":"89","author":"Basse","year":"2002","journal-title":"Br J Surg"},{"key":"R20-16-20210902","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1046\/j.0007-1323.2001.01905.x","article-title":"\u2018Fast track\u2019 postoperative management protocol for patients with high co-morbidity undergoing complex abdominal and pelvic colorectal surgery.","volume":"88","author":"Delaney","year":"2001","journal-title":"Br J Surg"},{"key":"R21-16-20210902","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0140-6736(03)14966-5","article-title":"Anaesthesia, surgery, and challenges in postoperative recovery.","volume":"362","author":"Kehlet","year":"2003","journal-title":"Lancet"},{"key":"R22-16-20210902","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/01.sla.0000094300.36689.ad","article-title":"The role of epidural anesthesia and analgesia in surgical practice.","volume":"238","author":"Moraca","year":"2003","journal-title":"Ann Surg"},{"key":"R23-16-20210902","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.amjsurg.2005.10.026","article-title":"Postoperative upper and lower gastrointestinal recovery and gastrointestinal morbidity in patients undergoing bowel resection: pooled analysis of placebo data from 3 randomized controlled trials.","volume":"191","author":"Delaney","year":"2006","journal-title":"Am J Surg"},{"key":"R24-16-20210902","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1463-1318.2006.00955.x","article-title":"Laparoscopic colonic surgery\u2014mission accomplished or work in progress?","volume":"8","author":"Kehlet","year":"2006","journal-title":"Colorectal Dis"},{"key":"R25-16-20210902","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1067\/j.cpsurg.2005.10.003","article-title":"The management of postoperative ileus.","volume":"43","author":"Person","year":"2006","journal-title":"Curr Probl Surg"},{"key":"R26-16-20210902","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.2165\/00003495-200262180-00004","article-title":"Postoperative ileus: progress towards effective management.","volume":"62","author":"Holte","year":"2002","journal-title":"Drugs"},{"key":"R28-16-20210902","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00464-005-0104-y","article-title":"Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study.","volume":"20","author":"Viscusi","year":"2006","journal-title":"Surg Endosc"},{"key":"R30-16-20210902","first-page":"A893","article-title":"A double-blind, randomized, placebo-controlled trial of methylnaltrexone (MNTX) for post-operative bowel dysfunction in segmental colectomy patients.","volume":"103","author":"Viscusi","year":"2005","journal-title":"Anesthesiology"},{"key":"R31-16-20210902","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1365-2036.2008.03696.x","article-title":"Clinical trial: alvimopan for the management of postoperative ileus after abdominal surgery: results of an international randomised, double-blind, multicentre, placebo-controlled clinical study.","volume":"28","author":"Buchler","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"R33-16-20210902","doi-asserted-by":"crossref","first-page":"II6","DOI":"10.1136\/gut.45.2008.ii6","article-title":"Fundamentals of neurogastroenterology.","volume":"45","author":"Wood","year":"1999","journal-title":"Gut"},{"key":"R34-16-20210902","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM199604253341707","article-title":"The enteric nervous system.","volume":"334","author":"Goyal","year":"1996","journal-title":"N Engl J Med"},{"key":"R37-16-20210902","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1523\/JNEUROSCI.15-05-03328.1995","article-title":"Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord.","volume":"15","author":"Arvidsson","year":"1995","journal-title":"J Neurosci"},{"key":"R38-16-20210902","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3810\/pgm.2004.09.1581","article-title":"Opioids for chronic noncancer pain. Tailoring therapy to fit the patient and the pain.","volume":"116","author":"Antoin","year":"2004","journal-title":"Postgrad Med"},{"key":"R39-16-20210902","doi-asserted-by":"crossref","first-page":"G8","DOI":"10.1152\/ajpgi.2001.281.1.G8","article-title":"Receptors and transmission in the brain-gut axis: potential for novel therapies. III. Mu-opioid receptors in the enteric nervous system.","volume":"281","author":"Sternini","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R40-16-20210902","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1743-3150.2004.00555.x","article-title":"Preclinical studies of opioids and opioid antagonists on gastrointestinal function.","volume":"16","author":"Greenwood-Van Meerveld","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"R41-16-20210902","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1213\/01.ANE.0000090147.97636.77","article-title":"Are peripheral opioid antagonists the solution to opioid side effects?","volume":"98","author":"Bates","year":"2004","journal-title":"Anesth Analg"},{"key":"R42-16-20210902","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1743-3150.2004.00554.x","article-title":"Function of opioids in the enteric nervous system.","volume":"16","author":"Wood","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"R43-16-20210902","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2005.08.008","article-title":"[3H]Alvimopan binding to the micro opioid receptor: comparative binding kinetics of opioid antagonists.","volume":"520","author":"Cassel","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"R44-16-20210902","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00210-007-0146-x","article-title":"The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.","volume":"375","author":"Beattie","year":"2007","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"R45-16-20210902","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1177\/0091270004273491","article-title":"Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans.","volume":"45","author":"Yuan","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"R46-16-20210902","doi-asserted-by":"crossref","first-page":"19S","DOI":"10.1016\/S0002-9610(01)00783-8","article-title":"A review of the potential role of methylnaltrexone in opioid bowel dysfunction.","volume":"182","author":"Foss","year":"2001","journal-title":"Am J Surg"},{"key":"R47-16-20210902","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3109\/00498258909043176","article-title":"Variations in demethylation of N-methylnaltrexone in mice, rats, dogs, and humans.","volume":"19","author":"Kotake","year":"1989","journal-title":"Xenobiotica"},{"key":"R48-16-20210902","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1021\/jm00041a003","article-title":"Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.","volume":"37","author":"Zimmerman","year":"1994","journal-title":"J Med Chem"},{"key":"R49-16-20210902","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1067\/mcp.2001.112680","article-title":"ADL 8-2698, a trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine, prevents gastrointestinal effects of intravenous morphine without affecting analgesia.","volume":"69","author":"Liu","year":"2001","journal-title":"Clin Pharmacol Ther"},{"key":"R52-16-20210902","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/sj.clpt.6100292","article-title":"Pharmacokinetics of alvimopan and its metabolite in healthy volunteers and patients in postoperative ileus trials.","volume":"83","author":"Foss","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"R53-16-20210902","first-page":"176","article-title":"Alvimopan: a peripherally selective opioid mu receptor antagonist.","volume":"40","author":"Udeh","year":"2005","journal-title":"Formulary"},{"key":"R56-16-20210902","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1056\/NEJMoa010564","article-title":"Selective postoperative inhibition of gastrointestinal opioid receptors.","volume":"345","author":"Taguchi","year":"2001","journal-title":"N Engl J Med"},{"key":"R58-16-20210902","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajog.2006.01.039","article-title":"A double-blind, randomized, placebo-controlled phase III study of the safety of alvimopan in patients who undergo simple total abdominal hysterectomy.","volume":"195","author":"Herzog","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"R59-16-20210902","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jamcollsurg.2007.02.026","article-title":"Patterns of gastrointestinal recovery after bowel resection and total abdominal hysterectomy: pooled results from the placebo arms of alvimopan phase III North American clinical trials.","volume":"205","author":"Wolff","year":"2007","journal-title":"J Am Coll Surg"},{"key":"R60-16-20210902","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1517\/13543784.15.5.541","article-title":"Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects.","volume":"15","author":"Yuan","year":"2006","journal-title":"Expert Opin Investig Drugs"},{"key":"R61-16-20210902","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0009-9236(96)90117-4","article-title":"Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial.","volume":"59","author":"Yuan","year":"1996","journal-title":"Clin Pharmacol Ther"},{"key":"R62-16-20210902","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0304-3959(99)00162-1","article-title":"Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot study.","volume":"83","author":"Yuan","year":"1999","journal-title":"Pain"},{"key":"R63-16-20210902","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1001\/jama.283.3.367","article-title":"Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.","volume":"283","author":"Yuan","year":"2000","journal-title":"JAMA"},{"key":"R64-16-20210902","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1345\/aph.1K009","article-title":"Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects.","volume":"41","author":"Yuan","year":"2007","journal-title":"Ann Pharmacother"},{"key":"R68-16-20210902","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/01.sla.0000232538.72458.93","article-title":"Alvimopan, for postoperative ileus following bowel resection: a pooled analysis of phase III studies.","volume":"245","author":"Delaney","year":"2007","journal-title":"Ann Surg"},{"key":"R69-16-20210902","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2036.2006.03150.x","article-title":"Meta-analysis: alvimopan vs. placebo in the treatment of post-operative ileus.","volume":"25","author":"Tan","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"R70-16-20210902","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jamcollsurg.2007.01.041","article-title":"Postoperative ileus-related morbidity profile in patients treated with alvimopan after bowel resection.","volume":"204","author":"Wolff","year":"2007","journal-title":"J Am Coll Surg"},{"key":"R71-16-20210902","first-page":"S178","article-title":"Alvimopan accelerates gastrointestinal recovery and decreases length of hospital stay after bowel resection without compromising opioid-based analgesia.","volume":"104","author":"Viscusi","year":"2007","journal-title":"Anesth Analg"},{"key":"R72-16-20210902","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/009127009703700105","article-title":"Safety and tolerance of methylnaltrexone in healthy humans: a randomized, placebo-controlled, intravenous, ascending-dose, pharmacokinetic study.","volume":"37","author":"Foss","year":"1997","journal-title":"J Clin Pharmacol"},{"key":"R75-16-20210902","doi-asserted-by":"crossref","first-page":"27S","DOI":"10.1016\/S0002-9610(01)00784-X","article-title":"Alvimopan* (ADL 8-2698) is a novel peripheral opioid antagonist.","volume":"182","author":"Schmidt","year":"2001","journal-title":"Am J Surg"},{"key":"R76-16-20210902","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.jopan.2006.01.014","article-title":"Nurses are everywhere: a practical perspective on the surgical team in managing postoperative ileus.","volume":"21","author":"Saufl","year":"2006","journal-title":"J Perianesth Nurs"},{"key":"R77-16-20210902","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.jopan.2006.01.016","article-title":"Peripherally acting mu-opioid-receptor antagonists and the connection between postoperative ileus and pain management: the anesthesiologist\u2019s view and beyond.","volume":"21","author":"Sinatra","year":"2006","journal-title":"J Perianesth Nurs"},{"key":"R78-16-20210902","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/MJT.0b013e31804c6f37","article-title":"New therapies in the treatment of postoperative ileus after gastrointestinal surgery.","volume":"15","author":"Maron","year":"2008","journal-title":"Am J Ther"},{"key":"R80-16-20210902","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1399-6576.2005.00674.x","article-title":"Effect of adding ketorolac to intravenous morphine patient-controlled analgesia on bowel function in colorectal surgery patients-a prospective, randomized, double-blind study.","volume":"49","author":"Chen","year":"2005","journal-title":"Acta Anaesthesiol Scand"},{"key":"R81-16-20210902","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0885-3924(02)00628-0","article-title":"Strategies in pain management: new and potential indications for COX-2 specific inhibitors.","volume":"25","author":"Ruoff","year":"2003","journal-title":"J Pain Symptom Manage"},{"key":"R82-16-20210902","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.0001-5172.2004.0329.x","article-title":"Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind trial.","volume":"48","author":"Dierking","year":"2004","journal-title":"Acta Anaesthesiol Scand"},{"key":"R84-16-20210902","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1091-255X(01)00009-9","article-title":"Does mechanical massage of the abdominal wall after colectomy reduce postoperative pain and shorten the duration of ileus? Results of a randomized study.","volume":"6","author":"Le Blanc-Louvry","year":"2002","journal-title":"J Gastrointest Surg"},{"key":"R85-16-20210902","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1072-7515(02)01179-1","article-title":"Gum chewing enhances early recovery from postoperative ileus after laparoscopic colectomy.","volume":"195","author":"Asao","year":"2002","journal-title":"J Am Coll Surg"},{"key":"R86-16-20210902","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jamcollsurg.2006.02.009","article-title":"Does gum chewing ameliorate postoperative ileus? Results of a prospective, randomized, placebo-controlled trial.","volume":"202","author":"Matros","year":"2006","journal-title":"J Am Coll Surg"},{"key":"R87-16-20210902","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1463-1318.2005.00884.x","article-title":"Does gum chewing reduce postoperative ileus following open colectomy for left-sided colon and rectal cancer? A prospective randomized controlled trial.","volume":"8","author":"Quah","year":"2006","journal-title":"Colorectal Dis"}],"container-title":["Anesthesia & Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ane.0b013e31819e0d3a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:12:15Z","timestamp":1786111935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-200906000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e31819e0d3a","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}