{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:31:15Z","timestamp":1791307875223,"version":"4.3.1"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1213\/ane.0b013e3181a9d8d9","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T03:16:20Z","timestamp":1253070980000},"page":"1065-1069","source":"Crossref","is-referenced-by-count":113,"title":["The Relationship Between Exertional Heat Illness, Exertional Rhabdomyolysis, and Malignant Hyperthermia"],"prefix":"10.1213","volume":"109","author":[{"given":"John F.","family":"Capacchione","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M.","family":"Muldoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20210902","first-page":"798","article-title":"Cecil medicine. 23rd ed.","author":"O'Connor","year":"2008"},{"key":"R2-13-20210902","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/01.CSMR.0000313392.79569.e7","article-title":"Exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia: is there a link?","volume":"7","author":"Muldoon","year":"2008","journal-title":"Curr Sports Med Rep"},{"key":"R3-13-20210902","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2174\/1566524023362429","article-title":"Malignant hyperthermia: a pharmacogenetic disease of Ca++ regulating proteins.","volume":"2","author":"Nelson","year":"2002","journal-title":"Curr Mol Med"},{"key":"R4-13-20210902","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1123\/jsr.16.3.163","article-title":"Recovery and return to activity following exertional heat stroke: considerations for the sports medicine staff.","volume":"16","author":"McDermott","year":"2007","journal-title":"J Sport Rehabil"},{"key":"R5-13-20210902","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/mus.10053","article-title":"Rhabdomyolysis: a review.","volume":"25","author":"Warren","year":"2002","journal-title":"Muscle Nerve"},{"key":"R6-13-20210902","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/jama.286.2.168","article-title":"Malignant hyperthermia and apparent heat stroke.","volume":"286","author":"Tobin","year":"2001","journal-title":"JAMA"},{"key":"R7-13-20210902","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/343559a0","article-title":"Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia.","volume":"343","author":"MacLennan","year":"1990","journal-title":"Nature"},{"key":"R8-13-20210902","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1001\/jama.1982.03320400018018","article-title":"Thermic stress syndrome.","volume":"247","author":"Meyers","year":"1982","journal-title":"JAMA"},{"key":"R9-13-20210902","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/jama.1981.03320010023020","article-title":"Treatment of heat stroke by dantrolene.","volume":"246","author":"Lydiatt","year":"1981","journal-title":"JAMA"},{"key":"R10-13-20210902","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/milmed\/147.1.8","article-title":"Physiologic stress, heat stroke, malignant hyperthermia\u2014 a perspective.","volume":"147","author":"Jardon","year":"1982","journal-title":"Mil Med"},{"key":"R11-13-20210902","first-page":"434","article-title":"Malignant hyperthermia.","volume":"58","author":"Gatz","year":"1973","journal-title":"Nebr Med J"},{"key":"R12-13-20210902","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1213\/00000539-198005000-00011","article-title":"Human malignant hyperthermia: awake episodes and correction by dantrolene.","volume":"59","author":"Gronert","year":"1980","journal-title":"Anesth Analg"},{"key":"R13-13-20210902","first-page":"79","article-title":"Malignant hyperthermia\u2014current concepts.","author":"Wingard","year":"1977"},{"key":"R14-13-20210902","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/00913847.1987.11704818","article-title":"Malignant hyperthermia in a college football player.","volume":"15","author":"Hunter","year":"1987","journal-title":"Phys Sportsmed"},{"key":"R15-13-20210902","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1399-6576.1983.tb01966.x","article-title":"Studies of body temperature, blood lactate, cortisol and free fatty acid levels during exercise in human subjects susceptible to malignant hyperpyrexia.","volume":"27","author":"Campbell","year":"1983","journal-title":"Acta Anaesthesiol Scand"},{"key":"R16-13-20210902","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1399-6576.1987.tb02533.x","article-title":"Thermoregulation, plasma catecholamine and metabolite levels during submaximal work in individuals susceptible to malignant hyperpyrexia.","volume":"31","author":"Green","year":"1987","journal-title":"Acta Anaesthesiol Scand"},{"key":"R17-13-20210902","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/bja\/66.1.138","article-title":"Muscle biopsy for diagnosis of malignant hyperthermia susceptibility in two patients with severe exercise-induced myolysis.","volume":"66","author":"Hackl","year":"1991","journal-title":"Br J Anaesth"},{"key":"R18-13-20210902","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0140-6736(91)92304-K","article-title":"Evidence for related myopathies in exertional heat stroke and malignant hyperthermia.","volume":"338","author":"Hopkins","year":"1991","journal-title":"Lancet"},{"key":"R19-13-20210902","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0960-8966(93)90114-Y","article-title":"Pathological findings in 165 patients explored for malignant hyperthermia susceptibility.","volume":"3","author":"Figarella-Branger","year":"1993","journal-title":"Neuromuscul Disord"},{"key":"R20-13-20210902","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/036354659602400109","article-title":"Postexercise muscle cramping associated with positive malignant hyperthermia contracture testing.","volume":"24","author":"Ogletree","year":"1996","journal-title":"Am J Sports Med"},{"key":"R21-13-20210902","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/0310057X9802600317","article-title":"Rhabdomyolysis following severe physical exercise in a patient with predisposition to malignant hyperthermia.","volume":"26","author":"Kochling","year":"1998","journal-title":"Anaesth Intensive Care"},{"key":"R22-13-20210902","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/00000539-200109000-00030","article-title":"A noninvasive investigation of muscle energetics supports similarities between exertional heat stroke and malignant hyperthermia.","volume":"93","author":"Bendahan","year":"2001","journal-title":"Anesth Analg"},{"key":"R23-13-20210902","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0952-8180(96)00207-3","article-title":"Sudden unexplained death in a patient with a family history of malignant hyperthermia.","volume":"9","author":"Ryan","year":"1997","journal-title":"J Clin Anesth"},{"key":"R24-13-20210902","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0022-510X(91)90120-V","article-title":"In vitro contraction test for malignant hyperthermia in patients with unexplained recurrent rhabdomyolysis.","volume":"105","author":"Poels","year":"1991","journal-title":"J Neurol Sci"},{"key":"R25-13-20210902","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1213\/00000539-199705000-00016","article-title":"Malignant hyperthermia testing in patients with persistently increased serum creatine kinase levels.","volume":"84","author":"Weglinski","year":"1997","journal-title":"Anesth Analg"},{"key":"R26-13-20210902","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00000542-200101000-00019","article-title":"Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomyolysis.","volume":"94","author":"Wappler","year":"2001","journal-title":"Anesthesiology"},{"key":"R27-13-20210902","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/bja\/88.4.508","article-title":"Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees.","volume":"88","author":"Davis","year":"2002","journal-title":"Br J Anaesth"},{"key":"R28-13-20210902","doi-asserted-by":"crossref","first-page":"44609","DOI":"10.1007\/BF03020021","article-title":"Mutations in RYR1 gene associated with malignant hyperthermia and a non-anaesthetic phenotype.","volume":"54","author":"Loke","year":"2007","journal-title":"Can J Anaesth"},{"key":"R29-13-20210902","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0733-8619(05)70179-1","article-title":"The molecular diagnosis of metabolic myopathies.","volume":"18","author":"Vladutiu","year":"2000","journal-title":"Neurol Clin"},{"key":"R30-13-20210902","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/00000542-199803000-00006","article-title":"The sensitivity and specificity of the caffeine-halothane contracture test: a report from the North American Malignant Hyperthermia Registry. The North American Malignant Hyperthermia Registry of MHAUS.","volume":"88","author":"Allen","year":"1998","journal-title":"Anesthesiology"},{"key":"R31-13-20210902","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/mus.880110507","article-title":"Halothane-caffeine contracture testing in neuromuscular diseases.","volume":"11","author":"Heiman-Patterson","year":"1988","journal-title":"Muscle Nerve"},{"key":"R32-13-20210902","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/bja\/68.1.72","article-title":"In vitro contracture tests in patients with various neuromuscular diseases.","volume":"68","author":"Heytens","year":"1992","journal-title":"Br J Anaesth"},{"key":"R33-13-20210902","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/00000542-199803000-00007","article-title":"Bayesian modeling of muscle biopsy contracture testing for malignant hyperthermia susceptibility.","volume":"88","author":"Loke","year":"1998","journal-title":"Anesthesiology"},{"key":"R34-13-20210902","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1399-6576.1997.tb04820.x","article-title":"In vitro contracture test for diagnosis of malignant hyperthermia following the protocol of the European MH Group: results of testing patients surviving fulminant MH and unrelated low-risk subjects. The European Malignant Hyperthermia Group.","volume":"41","author":"Ording","year":"1997","journal-title":"Acta Anaesthesiol Scand"},{"key":"R35-13-20210902","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cell.2008.02.042","article-title":"RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice.","volume":"133","author":"Durham","year":"2008","journal-title":"Cell"},{"key":"R36-13-20210902","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1152\/japplphysiol.90926.2008","article-title":"Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice.","volume":"105","author":"Corona","year":"2008","journal-title":"J Appl Physiol"},{"key":"R37-13-20210902","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/bja\/88.5.700","article-title":"Heat stroke: implications for critical care and anaesthesia.","volume":"88","author":"Grogan","year":"2002","journal-title":"Br J Anaesth"}],"container-title":["Anesthesia & Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ane.0b013e3181a9d8d9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:28:01Z","timestamp":1786112881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-200910000-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e3181a9d8d9","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}