{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:36:53Z","timestamp":1787315813670,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1213\/ane.0b013e3181c0724a","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T08:31:34Z","timestamp":1261038694000},"page":"174-180","source":"Crossref","is-referenced-by-count":14,"title":["The Brain Is a Source of S100B Increase During Endotoxemia in the Pig"],"prefix":"10.1213","volume":"110","author":[{"given":"Miklos","family":"Lipcsey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matts","family":"Olovsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Einarsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran A.","family":"Qadhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sj\u00f6lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-30-20210902","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000.","volume":"348","author":"Martin","year":"2003","journal-title":"N Engl J Med"},{"key":"R2-30-20210902","first-page":"297","article-title":"The encephalopathy associated with septic illness.","volume":"13","author":"Young","year":"1990","journal-title":"Clin Invest Med"},{"key":"R3-30-20210902","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1046\/j.1469-7580.2002.00065.x","article-title":"Blood-brain barrier breakdown and oedema formation in systemic sepsis and human brain tumours.","volume":"200","author":"Davies","year":"2002","journal-title":"J Anat"},{"key":"R4-30-20210902","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/CS19980327","article-title":"Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex.","volume":"96","author":"Papadopoulos","year":"1999","journal-title":"Clin Sci (Lond)"},{"key":"R5-30-20210902","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00003246-198905000-00004","article-title":"Cerebral blood flow is reduced in patients with sepsis syndrome.","volume":"17","author":"Bowton","year":"1989","journal-title":"Crit Care Med"},{"key":"R6-30-20210902","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0735-6757(91)90175-J","article-title":"Cerebral circulation and metabolism in patients with septic encephalopathy.","volume":"9","author":"Maekawa","year":"1991","journal-title":"Am J Emerg Med"},{"key":"R7-30-20210902","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.2741\/1250","article-title":"Sepsis associated encephalopathy (SAE): a review.","volume":"9","author":"Green","year":"2004","journal-title":"Front Biosci"},{"key":"R8-30-20210902","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1023\/A:1009212521172","article-title":"New perspectives on S100 proteins: a multi-functional Ca(2+)-, Zn(2+)- and Cu(2+)-binding protein family.","volume":"11","author":"Heizmann","year":"1998","journal-title":"Biometals"},{"key":"R9-30-20210902","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0361-9230(95)00040-2","article-title":"The S100 protein family: history, function, and expression.","volume":"37","author":"Zimmer","year":"1995","journal-title":"Brain Res Bull"},{"key":"R10-30-20210902","first-page":"d1356","article-title":"S100 proteins: structure, functions and pathology.","volume":"7","author":"Heizmann","year":"2002","journal-title":"Front Biosci"},{"key":"R11-30-20210902","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/0888-7543(95)80005-7","article-title":"Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.","volume":"25","author":"Schafer","year":"1995","journal-title":"Genomics"},{"key":"R12-30-20210902","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF02889881","article-title":"Immunohistochemical study on the distribution of alpha and beta subunits of S-100 protein in human neoplasm and normal tissues.","volume":"45","author":"Takahashi","year":"1984","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"R13-30-20210902","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/ijc.1504","article-title":"On the release and half-life of S100B protein in the peripheral blood of melanoma patients.","volume":"94","author":"Ghanem","year":"2001","journal-title":"Int J Cancer"},{"key":"R14-30-20210902","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0006-8993(02)02586-6","article-title":"Serum S-100beta as a possible marker of blood-brain barrier disruption.","volume":"940","author":"Kapural","year":"2002","journal-title":"Brain Res"},{"key":"R15-30-20210902","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cccn.2003.12.008","article-title":"Peripheral markers of blood-brain barrier damage.","volume":"342","author":"Marchi","year":"2004","journal-title":"Clin Chim Acta"},{"key":"R16-30-20210902","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1161\/01.STR.29.11.2363","article-title":"Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia.","volume":"29","author":"Martens","year":"1998","journal-title":"Stroke"},{"key":"R17-30-20210902","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.STR.29.2.473","article-title":"Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiac arrest.","volume":"29","author":"Rosen","year":"1998","journal-title":"Stroke"},{"key":"R19-30-20210902","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1080\/02699050050203540","article-title":"The clinical value of serum S-100 protein measurements in minor head injury: a Scandinavian multicentre study.","volume":"14","author":"Ingebrigtsen","year":"2000","journal-title":"Brain Inj"},{"key":"R20-30-20210902","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1093\/clinchem\/48.12.2097","article-title":"S100B protein in biological fluids: a tool for perinatal medicine.","volume":"48","author":"Michetti","year":"2002","journal-title":"Clin Chem"},{"key":"R21-30-20210902","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0300-9572(00)00348-8","article-title":"Serum levels of the brain-derived proteins S-100 and NSE predict long-term outcome after cardiac arrest.","volume":"49","author":"Rosen","year":"2001","journal-title":"Resuscitation"},{"key":"R22-30-20210902","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/00365540310017294","article-title":"Serum S100B levels in patients with cerebral and extracerebral infectious disease.","volume":"36","author":"Unden","year":"2004","journal-title":"Scand J Infect Dis"},{"key":"R23-30-20210902","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/01.shk.0000209546.06801.d7","article-title":"Increased levels of serum S100B protein in critically ill patients without brain injury.","volume":"26","author":"Routsi","year":"2006","journal-title":"Shock"},{"key":"R24-30-20210902","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1097\/01.CCM.0000217218.51381.49","article-title":"Elevated serum levels of S-100beta protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock.","volume":"34","author":"Nguyen","year":"2006","journal-title":"Crit Care Med"},{"key":"R25-30-20210902","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/bja\/aem201","article-title":"Elevated S100B levels do not correlate with the severity of encephalopathy during sepsis.","volume":"99","author":"Piazza","year":"2007","journal-title":"Br J Anaesth"},{"key":"R26-30-20210902","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1213\/01.ANE.0000180193.29655.6A","article-title":"Slight increase of serum S-100B during porcine endotoxemic shock may indicate blood-brain barrier damage.","volume":"101","author":"Larsson","year":"2005","journal-title":"Anesth Analg"},{"key":"R27-30-20210902","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/003655101300133658","article-title":"Renal elimination of protein S-100beta in pigs with acute encephalopathy.","volume":"61","author":"Ytrebo","year":"2001","journal-title":"Scand J Clin Lab Invest"},{"key":"R28-30-20210902","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1080\/003655200750023831","article-title":"Protein S-100beta: a biochemical marker for increased intracranial pressure in pigs with acute hepatic failure.","volume":"35","author":"Ytrebo","year":"2000","journal-title":"Scand J Gastroenterol"},{"key":"R29-30-20210902","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1080\/140174300750064495","article-title":"Serum S-100beta protein predicts brain injury after hypothermic circulatory arrest in pigs.","volume":"34","author":"Pokela","year":"2000","journal-title":"Scand Cardiovasc J"},{"key":"R30-30-20210902","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1213\/00000539-200210000-00044","article-title":"Hypertonic-hyperoncotic solutions reduce the release of cardiac troponin I and s-100 after successful cardiopulmonary resuscitation in pigs.","volume":"95","author":"Krieter","year":"2002","journal-title":"Anesth Analg"},{"key":"R31-30-20210902","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1053\/jcan.2000.18444","article-title":"Elimination of S100B and renal function after cardiac surgery.","volume":"14","author":"Jonsson","year":"2000","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R32-30-20210902","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/neu.2006.23.1185","article-title":"A critical analysis of the role of the neurotrophic protein S100B in acute brain injury.","volume":"23","author":"Kleindienst","year":"2006","journal-title":"J Neurotrauma"},{"key":"R33-30-20210902","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2460\/ajvr.1982.43.02.262","article-title":"Effects of continuous intravenous infusion of Escherichia coli endotoxin into swine.","volume":"43","author":"Kurtz","year":"1982","journal-title":"Am J Vet Res"},{"key":"R34-30-20210902","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1213\/01.ANE.0000181337.03655.0C","article-title":"Brain and sepsis: functional impairment, structural damage, and markers.","volume":"101","author":"Stocchetti","year":"2005","journal-title":"Anesth Analg"}],"container-title":["Anesthesia & Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ANE.0b013e3181c0724a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:35:20Z","timestamp":1786113320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-201001000-00030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e3181c0724a","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}