{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:22:54Z","timestamp":1792740174040,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1213\/ane.0b013e3181f579de","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T07:24:26Z","timestamp":1285226666000},"page":"1452-1459","source":"Crossref","is-referenced-by-count":55,"title":["Continuous Subcutaneous Instillation of Bupivacaine Compared to Saline Reduces Interleukin 10 and Increases Substance P in Surgical Wounds After Cesarean Delivery"],"prefix":"10.1213","volume":"111","author":[{"given":"Brendan","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Yeomans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Angst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20210902","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.jamcollsurg.2006.08.007","article-title":"Efficacy of continuous wound catheters delivering local anesthetic for postoperative analgesia: a quantitative and qualitative systematic review of randomized controlled trials.","volume":"203","author":"Liu","year":"2006","journal-title":"J Am Coll Surg"},{"key":"R2-20-20210902","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1067\/mob.2002.122984","article-title":"A randomized trial of postoperative wound irrigation with local anesthetic for pain after cesarean delivery.","volume":"186","author":"Givens","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"R3-20-20210902","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1097\/00000539-200012000-00025","article-title":"The analgesic efficacy of patient-controlled ropivacaine instillation after cesarean delivery.","volume":"91","author":"Fredman","year":"2000","journal-title":"Anesth Analg"},{"key":"R4-20-20210902","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.arthro.2009.01.019","article-title":"Pain pump use after shoulder arthroscopy as a cause of glenohumeral chondrolysis.","volume":"25","author":"Busfield","year":"2009","journal-title":"Arthroscopy"},{"key":"R6-20-20210902","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00000542-200701000-00007","article-title":"Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy.","volume":"106","author":"Kaba","year":"2007","journal-title":"Anesthesiology"},{"key":"R7-20-20210902","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/SLA.0b013e31805dac11","article-title":"Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial.","volume":"246","author":"Herroeder","year":"2007","journal-title":"Ann Surg"},{"key":"R8-20-20210902","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004311-200341010-00003","article-title":"Anti-inflammatory effects of local anesthetic agents.","volume":"41","author":"Swanton","year":"2003","journal-title":"Int Anesthesiol Clin"},{"key":"R9-20-20210902","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1399-6576.2006.00936.x","article-title":"Anti-inflammatory properties of local anesthetics and their present and potential clinical implications.","volume":"50","author":"Cassuto","year":"2006","journal-title":"Acta Anaesthesiol Scand"},{"key":"R10-20-20210902","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/00000542-199709000-00023","article-title":"Influence of lidocaine on endotoxin-induced leukocyte-endothelial cell adhesion and macromolecular leakage in vivo.","volume":"87","author":"Schmidt","year":"1997","journal-title":"Anesthesiology"},{"key":"R11-20-20210902","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1182\/blood.V56.2.203.203","article-title":"Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites.","volume":"56","author":"MacGregor","year":"1980","journal-title":"Blood"},{"key":"R12-20-20210902","first-page":"434","article-title":"Lidocaine inhibits leukocyte migration and phagocytosis in monosodium urate crystal-induced synovitis in dogs.","volume":"10","author":"Paul","year":"1983","journal-title":"J Rheumatol"},{"key":"R13-20-20210902","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1399-6576.1993.tb03693.x","article-title":"Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro.","volume":"37","author":"Sinclair","year":"1993","journal-title":"Acta Anaesthesiol Scand"},{"key":"R14-20-20210902","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1046\/j.1365-2249.2002.01747.x","article-title":"Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells.","volume":"127","author":"Lahav","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"R15-20-20210902","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00000542-199207000-00011","article-title":"Influence of lidocaine on leukocyte function in the surgical wound.","volume":"77","author":"Eriksson","year":"1992","journal-title":"Anesthesiology"},{"key":"R16-20-20210902","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1744-8069-3-28","article-title":"Morphine reduces local cytokine expression and neutrophil infiltration after incision.","volume":"3","author":"Clark","year":"2007","journal-title":"Mol Pain"},{"key":"R17-20-20210902","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.npep.2006.06.002","article-title":"Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes.","volume":"40","author":"Dallos","year":"2006","journal-title":"Neuropeptides"},{"key":"R18-20-20210902","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/bbrc.1999.1455","article-title":"Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing.","volume":"265","author":"Sato","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"R19-20-20210902","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00011-003-1243-z","article-title":"Neuropeptides stimulate production of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in human dental pulp cells.","volume":"53","author":"Yamaguchi","year":"2004","journal-title":"Inflamm Res"},{"key":"R20-20-20210902","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jpain.2008.02.004","article-title":"Local and systemic release of cytokines, nerve growth factor, prostaglandin E2, and substance P in incisional wounds and serum following cesarean delivery.","volume":"9","author":"Carvalho","year":"2008","journal-title":"J Pain"},{"key":"R22-20-20210902","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/jpm.1999.2.209","article-title":"Opioid equianalgesic calculations.","volume":"2","author":"Gordon","year":"1999","journal-title":"J Palliat Med"},{"key":"R23-20-20210902","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine.","volume":"226","author":"Mosser","year":"2008","journal-title":"Immunol Rev"},{"key":"R24-20-20210902","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor.","volume":"19","author":"Moore","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"R25-20-20210902","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0952-8180(97)00264-X","article-title":"Interleukin-10 production during and after upper abdominal surgery.","volume":"10","author":"Kato","year":"1998","journal-title":"J Clin Anesth"},{"key":"R26-20-20210902","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1399-6576.2008.01590.x","article-title":"Bupivacaine inhibits COX-2 expression, PGE2, and cytokine production in endotoxin-activated macrophages.","volume":"52","author":"Huang","year":"2008","journal-title":"Acta Anaesthesiol Scand"},{"key":"R27-20-20210902","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3109\/00016480903352975","article-title":"Serial cytokine levels during wound healing in rabbit maxillary sinus mucosa.","volume":"130","author":"Sun","year":"2010","journal-title":"Acta Otolaryngol"},{"key":"R28-20-20210902","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1038\/sj.jid.5701232","article-title":"IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation.","volume":"128","author":"Peranteau","year":"2008","journal-title":"J Invest Dermatol"},{"key":"R29-20-20210902","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pain.2009.06.037","article-title":"Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision.","volume":"145","author":"Sahbaie","year":"2009","journal-title":"Pain"},{"key":"R30-20-20210902","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neulet.2008.03.081","article-title":"Neuropeptides, neurogenic inflammation and complex regional pain syndrome (CRPS).","volume":"437","author":"Birklein","year":"2008","journal-title":"Neurosci Lett"},{"key":"R31-20-20210902","first-page":"75","article-title":"Substance P and inflammatory pain: potential of substance P antagonists as analgesics.","volume":"41","author":"Henry","year":"1993","journal-title":"Agents Actions Suppl"},{"key":"R32-20-20210902","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jss.2008.03.051","article-title":"Substance P enhances wound closure in nitric oxide synthase knockout mice.","volume":"153","author":"Muangman","year":"2009","journal-title":"J Surg Res"},{"key":"R33-20-20210902","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.bcp.2009.03.003","article-title":"Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression.","volume":"77","author":"Rook","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"R34-20-20210902","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2044.2007.05324.x","article-title":"The inhibitory effects of local anaesthetics on the vascular flare responses to bradykinin and substance P in human skin.","volume":"63","author":"Dias","year":"2008","journal-title":"Anaesthesia"},{"key":"R35-20-20210902","first-page":"763","article-title":"The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons.","volume":"118","author":"Leffler","year":"2008","journal-title":"J Clin Invest"},{"key":"R36-20-20210902","first-page":"576","article-title":"Local anesthetic neurotoxicity: clinical injury and strategies that may minimize risk.","volume":"27","author":"Drasner","year":"2002","journal-title":"Reg Anesth Pain Med"},{"key":"R37-20-20210902","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0305-4179(03)00006-8","article-title":"Influence of local anaesthetics on inflammatory activity postburn.","volume":"29","author":"Yregard","year":"2003","journal-title":"Burns"},{"key":"R38-20-20210902","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1034\/j.1399-6576.1999.430605.x","article-title":"Effects of amide local anaesthetics on eicosanoid formation in burned skin.","volume":"43","author":"Jonsson","year":"1999","journal-title":"Acta Anaesthesiol Scand"},{"key":"R39-20-20210902","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1213\/01.ane.0000296474.79437.23","article-title":"The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.","volume":"106","author":"Gordon","year":"2008","journal-title":"Anesth Analg"},{"key":"R40-20-20210902","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1213\/00000539-199408000-00022","article-title":"Subcutaneously versus subfascially administered lidocaine in pain treatment after inguinal herniotomy.","volume":"79","author":"Yndgaard","year":"1994","journal-title":"Anesth Analg"},{"key":"R41-20-20210902","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1213\/01.ANE.0000078586.82810.3B","article-title":"The effects of postoperative pain management on immune response to surgery.","volume":"97","author":"Beilin","year":"2003","journal-title":"Anesth Analg"},{"key":"R42-20-20210902","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0304-3959(97)00120-6","article-title":"Effect of NSAID administration on tissue levels of immunoreactive prostaglandin E2, leukotriene B4, and (S)-flurbiprofen following extraction of impacted third molars.","volume":"73","author":"Roszkowski","year":"1997","journal-title":"Pain"}],"container-title":["Anesthesia &amp; Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ANE.0b013e3181f579de","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:17:33Z","timestamp":1786112253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-201012000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e3181f579de","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}