{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:22:27Z","timestamp":1786123347626,"version":"build-2736575974"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1213\/ane.0b013e3181fcea71","type":"journal-article","created":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T05:35:37Z","timestamp":1288848937000},"page":"130-138","source":"Crossref","is-referenced-by-count":27,"title":["Dopexamine Has No Additional Benefit in High-Risk Patients Receiving Goal-Directed Fluid Therapy Undergoing Major Abdominal Surgery"],"prefix":"10.1213","volume":"112","author":[{"given":"Simon J.","family":"Davies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Yates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Jonathan T.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20210902","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1001\/jama.1993.03510220055034","article-title":"A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients.","volume":"270","author":"Boyd","year":"1993","journal-title":"JAMA"},{"key":"R2-22-20210902","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1136\/bmj.318.7191.1099","article-title":"Reducing the risk of major elective surgery: randomised controlled trial of preoperative optimisation of oxygen delivery.","volume":"318","author":"Wilson","year":"1999","journal-title":"BMJ"},{"key":"R3-22-20210902","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1097\/00003246-200010000-00007","article-title":"Effect of dopexamine on outcome after major abdominal surgery: a prospective, randomized, controlled multicenter study. European Multicenter Study Group on Dopexamine in Major Abdominal Surgery.","volume":"28","author":"Takala","year":"2000","journal-title":"Crit Care Med"},{"key":"R4-22-20210902","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1378\/chest.94.6.1176","article-title":"Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients.","volume":"94","author":"Shoemaker","year":"1988","journal-title":"Chest"},{"key":"R5-22-20210902","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.100.10.1043","article-title":"Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery.","volume":"100","author":"Lee","year":"1999","journal-title":"Circulation"},{"key":"R6-22-20210902","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1378\/chest.130.2.517","article-title":"Cardiorespiratory fitness and short-term complications after bariatric surgery.","volume":"130","author":"McCullough","year":"2006","journal-title":"Chest"},{"key":"R7-22-20210902","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1067\/mtc.2001.113596","article-title":"Preoperative evaluation of cardiopulmonary reserve with the use of expired gas analysis during exercise testing in patients with squamous cell carcinoma of the thoracic esophagus.","volume":"121","author":"Nagamatsu","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R8-22-20210902","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1378\/chest.104.3.701","article-title":"Preoperative evaluation of cardiac failure and ischemia in elderly patients by cardiopulmonary exercise testing.","volume":"104","author":"Older","year":"1993","journal-title":"Chest"},{"key":"R9-22-20210902","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1164\/ajrccm.151.5.7735602","article-title":"Exercise capacity as a predictor of postoperative complications in lung resection candidates.","volume":"151","author":"Bolliger","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"R10-22-20210902","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1183\/09031936.98.11010198","article-title":"Functional evaluation of the lung resection candidate.","volume":"11","author":"Bolliger","year":"1998","journal-title":"Eur Respir J"},{"key":"R11-22-20210902","first-page":"39","article-title":"Low anaerobic threshold and ventilatory inefficiency predict all-cause mortality after major planned abdominal cancer or aortic surgery.","volume":"108","author":"Wilson","year":"2009","journal-title":"Anesth Analg"},{"key":"R12-22-20210902","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/bja\/aeq128","article-title":"Impaired functional capacity is associated with all-cause mortality after major elective intraabdominal surgery.","volume":"105","author":"Wilson","year":"2010","journal-title":"Br J Anaesth"},{"key":"R13-22-20210902","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1097\/CCM.0b013e31816a091b","article-title":"Effect of dopexamine infusion on mortality following major surgery: individual patient data meta-regression analysis of published clinical trials.","volume":"36","author":"Pearse","year":"2008","journal-title":"Crit Care Med"},{"key":"R14-22-20210902","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1365-2044.2009.05896.x","article-title":"Meta-analysis on the effect of dopexamine on in-hospital mortality.","volume":"64","author":"Gopal","year":"2009","journal-title":"Anaesthesia"},{"key":"R16-22-20210902","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1001\/jama.280.19.1690","article-title":"Whats the relative risk A method of correcting the odds ratio in cohort studies of common outcomes.","volume":"280","author":"Zhang","year":"1998","journal-title":"JAMA"},{"key":"R17-22-20210902","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1213\/00000539-199908000-00050","article-title":"The use of a postoperative morbidity survey to evaluate patients with prolonged hospitalization after routine, moderate-risk, elective surgery.","volume":"89","author":"Bennett-Guerrero","year":"1999","journal-title":"Anesth Analg"},{"key":"R18-22-20210902","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/bjs.1800780327","article-title":"POSSUM: a scoring system for surgical audit.","volume":"78","author":"Copeland","year":"1991","journal-title":"Br J Surg"},{"key":"R19-22-20210902","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/bjs.1800830628","article-title":"An evaluation of the POSSUM surgical scoring system.","volume":"83","author":"Whiteley","year":"1996","journal-title":"Br J Surg"},{"key":"R20-22-20210902","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1046\/j.1365-2044.2002.02708.x","article-title":"Randomised controlled trial investigating the influence of intravenous fluid titration using oesophageal Doppler monitoring during bowel surgery.","volume":"57","author":"Conway","year":"2002","journal-title":"Anaesthesia"},{"key":"R21-22-20210902","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/bjs.5454","article-title":"Randomized clinical trial assessing the effect of Doppler-optimized fluid management on outcome after elective colorectal resection.","volume":"93","author":"Noblett","year":"2006","journal-title":"Br J Surg"},{"key":"R22-22-20210902","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/bja\/aeg245","article-title":"Effect of adding dopexamine to intraoperative volume expansion in patients undergoing major elective abdominal surgery.","volume":"91","author":"Stone","year":"2003","journal-title":"Br J Anaesth"},{"key":"R23-22-20210902","doi-asserted-by":"crossref","first-page":"R687","DOI":"10.1186\/cc3887","article-title":"Early goal-directed therapy after major surgery reduces complications and duration of hospital stay: a randomised, controlled trial ISRCTN38797445.","volume":"9","author":"Pearse","year":"2005","journal-title":"Crit Care"},{"key":"R24-22-20210902","doi-asserted-by":"crossref","first-page":"41C","DOI":"10.1016\/S0002-9149(88)80066-3","article-title":"Clinical development of dopexamine hydrochloride (Dopacard) and an overview of its hemodynamic effects.","volume":"62","author":"Foulds","year":"1988","journal-title":"Am J Cardiol"},{"key":"R25-22-20210902","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/bja\/aen277","article-title":"Uncalibrated pulse contour-derived stroke volume variation predicts fluid responsiveness in mechanically ventilated patients undergoing liver transplantation.","volume":"101","author":"Biais","year":"2008","journal-title":"Br J Anaesth"},{"key":"R26-22-20210902","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1017\/S0265021507001056","article-title":"Comparison of FloTrac cardiac output monitoring system in patients undergoing coronary artery bypass grafting with pulmonary artery cardiac output measurements.","volume":"24","author":"Cannesson","year":"2007","journal-title":"Eur J Anaesthesiol"},{"key":"R27-22-20210902","doi-asserted-by":"crossref","first-page":"R164","DOI":"10.1186\/cc5103","article-title":"Comparison of uncalibrated arterial waveform analysis in cardiac surgery patients with thermodilution cardiac output measurements.","volume":"10","author":"Sander","year":"2006","journal-title":"Crit Care"},{"key":"R28-22-20210902","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1053\/j.jvca.2007.11.001","article-title":"The accuracy of the VigileoFloTrac continuous cardiac output monitor.","volume":"22","author":"Zimmermann","year":"2008","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R29-22-20210902","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1213\/ane.0b013e318161964d","article-title":"Cardiac output derived from arterial pressure waveform analysis in patients undergoing cardiac surgery: validity of a second generation device.","volume":"106","author":"Mayer","year":"2008","journal-title":"Anesth Analg"},{"key":"R30-22-20210902","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/bja\/86.6.794","article-title":"Oesophageal Doppler monitoring overestimates cardiac output during lumbar epidural anaesthesia.","volume":"86","author":"Leather","year":"2001","journal-title":"Br J Anaesth"},{"key":"R31-22-20210902","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1186\/cc8875","article-title":"Goal-directed intraoperative therapy based on autocalibrated arterial pressure waveform analysis reduces hospital stay in high-risk surgical patients: a randomized, controlled trial.","volume":"14","author":"Mayer","year":"2010","journal-title":"Crit Care"},{"key":"R32-22-20210902","doi-asserted-by":"crossref","first-page":"R118","DOI":"10.1186\/cc9070","article-title":"Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study.","volume":"14","author":"Benes","year":"2010","journal-title":"Crit Care"},{"key":"R33-22-20210902","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/00000539-200104000-00034","article-title":"Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgery.","volume":"92","author":"Berkenstadt","year":"2001","journal-title":"Anesth Analg"},{"key":"R34-22-20210902","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/jappl.1987.63.4.1487","article-title":"Pathological supply dependence of O2 uptake during bacteremia in dogs.","volume":"63","author":"Nelson","year":"1987","journal-title":"J Appl Physiol"},{"key":"R35-22-20210902","first-page":"1697","article-title":"Splanchnic ischemia and gut mucosal injury in sepsis and the multiple organ dysfunction syndrome.","volume":"91","author":"Pastores","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"R36-22-20210902","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s001340050366","article-title":"Gastrointestinal permeability following cardiopulmonary bypass: a randomised study comparing the effects of dopamine and dopexamine.","volume":"23","author":"Sinclair","year":"1997","journal-title":"Intensive Care Med"},{"key":"R37-22-20210902","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1378\/chest.108.6.1648","article-title":"Increasing splanchnic blood flow in the critically ill.","volume":"108","author":"Maynard","year":"1995","journal-title":"Chest"},{"key":"R38-22-20210902","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bja\/88.6.841","article-title":"Dopexamine attenuates microvascular perfusion injury of the small bowel in pigs induced by extracorporeal circulation.","volume":"88","author":"Sack","year":"2002","journal-title":"Br J Anaesth"},{"key":"R39-22-20210902","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s001340000604","article-title":"Pre-operative tonometry is predictive for mortality and morbidity in high-risk surgical patients.","volume":"26","author":"Poeze","year":"2000","journal-title":"Intensive Care Med"},{"key":"R40-22-20210902","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1001\/archsurg.1995.01430040085019","article-title":"Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery.","volume":"130","author":"Mythen","year":"1995","journal-title":"Arch Surg"},{"key":"R41-22-20210902","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.med.52.1.275","article-title":"Risk-adjusted surgical outcomes.","volume":"52","author":"Daley","year":"2001","journal-title":"Annu Rev Med"},{"key":"R42-22-20210902","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/intqhc\/7.3.219","article-title":"Appropriateness of hospital use: an overview of Italian studies.","volume":"7","author":"Fellin","year":"1995","journal-title":"Int J Qual Health Care"},{"key":"R43-22-20210902","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.jclinepi.2006.12.003","article-title":"The Postoperative Morbidity Survey was validated and used to describe morbidity after major surgery.","volume":"60","author":"Grocott","year":"2007","journal-title":"J Clin Epidemiol"},{"key":"R44-22-20210902","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/bja\/aei223","article-title":"Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery.","volume":"95","author":"Wakeling","year":"2005","journal-title":"Br J Anaesth"}],"container-title":["Anesthesia & Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ANE.0b013e3181fcea71","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:18:35Z","timestamp":1786112315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-201101000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e3181fcea71","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}