{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:23:42Z","timestamp":1786123422290,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1213\/ane.0b013e3182159c15","type":"journal-article","created":{"date-parts":[[2011,3,19]],"date-time":"2011-03-19T02:45:38Z","timestamp":1300502738000},"page":"112-119","source":"Crossref","is-referenced-by-count":11,"title":["Hydroxyethyl Starch (130 kD) Inhibits Toll-Like Receptor 4 Signaling Pathways in Rat Lungs Challenged with Lipopolysaccharide"],"prefix":"10.1213","volume":"113","author":[{"given":"Jie","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce E.","family":"Rundhaug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20210902","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1136\/bmj.39346.495880.AE","article-title":"Sepsis: definition, epidemiology, and diagnosis.","volume":"335","author":"Lever","year":"2007","journal-title":"BMJ"},{"key":"R2-20-20210902","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock.","volume":"345","author":"Rivers","year":"2001","journal-title":"N Engl J Med"},{"key":"R3-20-20210902","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.CCM.0000298158.12101.41","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock2008.","volume":"36","author":"Dellinger","year":"2008","journal-title":"Crit Care Med"},{"key":"R4-20-20210902","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1590\/S1807-59322008000100019","article-title":"Sepsis: from bench to bedside.","volume":"63","author":"Silva","year":"2008","journal-title":"Clinics (Sao Paulo)"},{"key":"R5-20-20210902","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/ALN.0b013e3181a7ec82","article-title":"Hydroxyethyl starches: different products-different effects.","volume":"111","author":"Westphal","year":"2009","journal-title":"Anesthesiology"},{"key":"R6-20-20210902","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1213\/01.ANE.0000099720.25581.86","article-title":"The effects of hydroxyethyl starch on lung capillary permeability in endotoxic rats and possible mechanisms.","volume":"98","author":"Tian","year":"2004","journal-title":"Anesth Analg"},{"key":"R7-20-20210902","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cca.2006.07.008","article-title":"Protective roles of hydroxyethyl starch 1300.4 in intestinal inflammatory response and survival in rats challenged with polymicrobial sepsis.","volume":"376","author":"Feng","year":"2007","journal-title":"Clin Chim Acta"},{"key":"R8-20-20210902","first-page":"451","article-title":"Hydroxyethyl starch inhibits NF-kappaB activation and prevents the expression of inflammatory mediators in endotoxic rats.","volume":"33","author":"Tian","year":"2003","journal-title":"Ann Clin Lab Sci"},{"key":"R9-20-20210902","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/BF03018364","article-title":"Volume replacement with HES 1300.4 may reduce the inflammatory response in patients undergoing major abdominal surgery.","volume":"50","author":"Lang","year":"2003","journal-title":"Can J Anaesth"},{"key":"R10-20-20210902","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/bja\/aen016","article-title":"Comparison of the effects of gelatin and a modern hydroxyethyl starch solution on renal function and inflammatory response in elderly cardiac surgery patients.","volume":"100","author":"Boldt","year":"2008","journal-title":"Br J Anaesth"},{"key":"R11-20-20210902","doi-asserted-by":"crossref","first-page":"457","DOI":"10.7326\/0003-4819-115-6-457","article-title":"The pathogenesis of sepsis.","volume":"115","author":"Bone","year":"1991","journal-title":"Ann Intern Med"},{"key":"R12-20-20210902","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis.","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N Engl J Med"},{"key":"R13-20-20210902","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.imbio.2007.09.010","article-title":"Role of Toll-like receptor responses for sepsis pathogenesis.","volume":"212","author":"Weighardt","year":"2007","journal-title":"Immunobiology"},{"key":"R14-20-20210902","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s12026-007-0069-0","article-title":"Regulation of interactions of gram-negative bacterial endotoxins with mammalian cells.","volume":"39","author":"Gioannini","year":"2007","journal-title":"Immunol Res"},{"key":"R15-20-20210902","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2006.12.002","article-title":"Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors.","volume":"19","author":"Miyake","year":"2007","journal-title":"Semin Immunol"},{"key":"R16-20-20210902","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.","volume":"7","author":"ONeill","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"R17-20-20210902","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades.","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"key":"R18-20-20210902","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/ni1255","article-title":"Essential function for the kinase TAK1 in innate and adaptive immune responses.","volume":"6","author":"Sato","year":"2005","journal-title":"Nat Immunol"},{"key":"R19-20-20210902","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPSTLR4 signal transduction pathway.","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"R20-20-20210902","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system.","volume":"2","author":"Li","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"R21-20-20210902","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/j.1399-6576.2005.00849.x","article-title":"Influence of hydroxyethyl starch on lipopolysaccharide-induced tissue nuclear factor kappa B activation and systemic TNF-alpha expression.","volume":"49","author":"Tian","year":"2005","journal-title":"Acta Anaesthesiol Scand"},{"key":"R22-20-20210902","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jss.2006.02.028","article-title":"Effects of hydroxyethyl starch 1300.4 on pulmonary capillary leakage and cytokines production and NF-kappaB activation in CLP-induced sepsis in rats.","volume":"135","author":"Feng","year":"2006","journal-title":"J Surg Res"},{"key":"R23-20-20210902","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/01.shk.0000245032.31859.f2","article-title":"Resuscitation with hydroxyethyl starch solution prevents nuclear factor kappaB activation and oxidative stress after hemorrhagic shock and resuscitation in rats.","volume":"27","author":"Tsai","year":"2007","journal-title":"Shock"},{"key":"R24-20-20210902","first-page":"R471","article-title":"Glucose kinetics and body temperature after lethal and nonlethal doses of endotoxin.","volume":"248","author":"Lang","year":"1985","journal-title":"Am J Physiol"},{"key":"R25-20-20210902","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0049-3848(95)00040-2","article-title":"Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats.","volume":"78","author":"Uchiba","year":"1995","journal-title":"Thromb Res"},{"key":"R26-20-20210902","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1158\/0008-5472.CAN-06-4064","article-title":"Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation.","volume":"67","author":"Sirianni","year":"2007","journal-title":"Cancer Res"},{"key":"R27-20-20210902","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1158\/0008-5472.CAN-08-3628","article-title":"Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells.","volume":"69","author":"Shirley","year":"2009","journal-title":"Cancer Res"},{"key":"R28-20-20210902","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1161\/01.ATV.0000246779.78003.cf","article-title":"The role of human antigen R, an RNA-binding protein, in mediating the stabilization of Toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation.","volume":"26","author":"Lin","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R29-20-20210902","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jama.1995.03530020090038","article-title":"Natural cytokine antagonists and endogenous antiendotoxin core antibodies in sepsis syndrome. The Sepsis Intervention Group.","volume":"274","author":"Goldie","year":"1995","journal-title":"JAMA"},{"key":"R30-20-20210902","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0898-6568(00)00149-2","article-title":"LPS induction of gene expression in human monocytes.","volume":"13","author":"Guha","year":"2001","journal-title":"Cell Signal"},{"key":"R31-20-20210902","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/eji.200323431","article-title":"Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice.","volume":"33","author":"Kalis","year":"2003","journal-title":"Eur J Immunol"},{"key":"R32-20-20210902","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3HHeJ and C57BL10ScCr mice: mutations in Tlr4 gene.","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"R33-20-20210902","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jss.2009.05.050","article-title":"Hydroxyethyl starch 1300.4 inhibits production of plasma proinflammatory cytokines and attenuates nuclear factor-kappaB activation and Toll-like receptors expression in monocytes during sepsis.","volume":"160","author":"Xie","year":"2010","journal-title":"J Surg Res"},{"key":"R34-20-20210902","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jss.2009.01.022","article-title":"Up-regulation of intestinal Toll-Like receptors and cytokines expressions change after TPN administration and a lack of enteral feeding.","volume":"160","author":"Ikeda","year":"2010","journal-title":"J Surg Res"},{"key":"R35-20-20210902","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MMBR.68.2.320-344.2004","article-title":"ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.","volume":"68","author":"Roux","year":"2004","journal-title":"Microbiol Mol Biol Rev"},{"key":"R36-20-20210902","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4049\/jimmunol.175.1.262","article-title":"Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome.","volume":"175","author":"Schnyder-Candrian","year":"2005","journal-title":"J Immunol"},{"key":"R37-20-20210902","doi-asserted-by":"crossref","first-page":"36993","DOI":"10.1074\/jbc.M302942200","article-title":"Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.","volume":"278","author":"Morse","year":"2003","journal-title":"J Biol Chem"},{"key":"R38-20-20210902","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1097\/CCM.0b013e3181a00268","article-title":"Effects of hydroxyethyl starch resuscitation on extravascular lung water and pulmonary permeability in sepsis-related acute respiratory distress syndrome.","volume":"37","author":"Huang","year":"2009","journal-title":"Crit Care Med"},{"key":"R39-20-20210902","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/00024382-200404000-00008","article-title":"Resuscitation from septic shock with capillary leakage: hydroxyethyl starch (130 kD), but not Ringers solution maintains plasma volume and systemic oxygenation.","volume":"21","author":"Marx","year":"2004","journal-title":"Shock"},{"key":"R40-20-20210902","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/SHK.0b013e318181a343","article-title":"Experimental models of sepsis and their clinical relevance.","volume":"30","author":"Poli-de-Figueiredo","year":"2008","journal-title":"Shock"}],"container-title":["Anesthesia & Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ANE.0b013e3182159c15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:25:20Z","timestamp":1786112720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-201107000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e3182159c15","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}