{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:21:20Z","timestamp":1786123280037,"version":"build-2736575974"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1213\/ane.0b013e31822402f5","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T11:00:56Z","timestamp":1308308456000},"page":"843-848","source":"Crossref","is-referenced-by-count":36,"title":["Nitrous Oxide Anesthesia and Plasma Homocysteine in Adolescents"],"prefix":"10.1213","volume":"113","author":[{"given":"Peter","family":"Nagele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Tallchief","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Blood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshuman","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan D.","family":"Kharasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-28-20210902","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(78)92341-3","article-title":"Selective inactivation of vitamin B12 in rats by nitrous oxide.","volume":"2","author":"Deacon","year":"1978","journal-title":"Lancet"},{"key":"R2-28-20210902","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/ALN.0b013e3181870a17","article-title":"Biologic effects of nitrous oxide: a mechanistic and toxicologic review.","volume":"109","author":"Sanders","year":"2008","journal-title":"Anesthesiology"},{"key":"R3-28-20210902","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/clpt.1991.45","article-title":"Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate in plasma and urine.","volume":"49","author":"Ermens","year":"1991","journal-title":"Clin Pharmacol Ther"},{"key":"R4-28-20210902","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1213\/00000539-199809000-00041","article-title":"The use of intraoperative nitrous oxide leads to postoperative increases in plasma homocysteine.","volume":"87","author":"Badner","year":"1998","journal-title":"Anesth Analg"},{"key":"R5-28-20210902","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1213\/00000539-198202000-00001","article-title":"Nitrous oxide inactivates methionine synthetase in human liver.","volume":"61","author":"Koblin","year":"1982","journal-title":"Anesth Analg"},{"key":"R6-28-20210902","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0140-6736(82)90808-X","article-title":"Incidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care.","volume":"320","author":"Amos","year":"1982","journal-title":"Lancet"},{"key":"R7-28-20210902","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1212\/WNL.28.5.504","article-title":"Neuropathy following abuse of nitrous oxide.","volume":"28","author":"Layzer","year":"1978","journal-title":"Neurology"},{"key":"R8-28-20210902","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1001\/archneur.57.3.380","article-title":"Nitrous oxide anesthesia-associated myelopathy.","volume":"57","author":"Marie","year":"2000","journal-title":"Arch Neurol"},{"key":"R9-28-20210902","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1056\/NEJMoa021867","article-title":"Adverse effect of nitrous oxide in a child with 5,10-methylenetetrahydrofolate reductase deficiency.","volume":"349","author":"Selzer","year":"2003","journal-title":"N Engl J Med"},{"key":"R10-28-20210902","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bpa.2005.03.003","article-title":"Nitrous oxide: an outdated anaesthetic.","volume":"19","author":"Jahn","year":"2005","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"R11-28-20210902","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1460-9592.2007.02264.x","article-title":"When nitrous oxide is no laughing matter: nitrous oxide and pediatric anesthesia.","volume":"17","author":"Baum","year":"2007","journal-title":"Pediatr Anesth"},{"key":"R12-28-20210902","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1309\/AJCP64BJIPNPSQDJ","article-title":"Performance characteristics of six homocysteine assays.","volume":"130","author":"Laulu","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"R13-28-20210902","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/0163278709338554","article-title":"Analyzing longitudinal data with the linear mixed models procedure in SPSS.","volume":"32","author":"West","year":"2009","journal-title":"Eval Health Prof"},{"key":"R14-28-20210902","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/bja\/aen085","article-title":"Effect of nitrous oxide on plasma homocysteine and folate in patients undergoing major surgery.","volume":"100","author":"Myles","year":"2008","journal-title":"Br J Anaesth"},{"key":"R15-28-20210902","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/ALN.0b013e318178820b","article-title":"Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia.","volume":"109","author":"Nagele","year":"2008","journal-title":"Anesthesiology"},{"key":"R16-28-20210902","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1373\/clinchem.2006.082149","article-title":"Genetic and environmental influences on plasma homocysteine: results from a Danish twin study.","volume":"53","author":"Bathum","year":"2007","journal-title":"Clin Chem"},{"key":"R17-28-20210902","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1067\/mpd.2000.107387","article-title":"Acute neurologic decompensation in an infant with cobalamin deficiency exposed to nitrous oxide.","volume":"137","author":"Felmet","year":"2000","journal-title":"J Pediatr"},{"key":"R18-28-20210902","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/00000542-199510000-00028","article-title":"Severe neurologic deficit after nitrous oxide anesthesia.","volume":"83","author":"Hadzic","year":"1995","journal-title":"Anesthesiology"},{"key":"R19-28-20210902","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/bja\/aei300","article-title":"Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase.","volume":"96","author":"Lacassie","year":"2006","journal-title":"Br J Anaesth"},{"key":"R20-28-20210902","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0140-6736(78)92101-3","article-title":"Myeloneuropathy after prolonged exposure to nitrous oxide.","volume":"2","author":"Layzer","year":"1978","journal-title":"Lancet"},{"key":"R21-28-20210902","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1136\/jnnp.60.3.354","article-title":"Severe combined degeneration of the spinal cord after nitrous oxide anaesthesia in a vegetarian.","volume":"60","author":"Rosener","year":"1996","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R23-28-20210902","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1001\/archsurg.1993.01420240099018","article-title":"Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.","volume":"128","author":"Flippo","year":"1993","journal-title":"Arch Surg"},{"key":"R24-28-20210902","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1212\/WNL.45.8.1608","article-title":"Anesthesia paresthetica: nitrous oxide-induced cobalamin deficiency.","volume":"45","author":"Kinsella","year":"1995","journal-title":"Neurology"},{"key":"R25-28-20210902","first-page":"43","article-title":"Myeloneuropathy from nitrous oxide abuse: unusually high methylmalonic acid and homocysteine levels.","volume":"102","author":"Waclawik","year":"2003","journal-title":"WMJ"},{"key":"R26-28-20210902","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0140-6736(78)92941-0","article-title":"Megaloblastic haemopoiesis in patients receiving nitrous oxide.","volume":"2","author":"Amess","year":"1978","journal-title":"Lancet"},{"key":"R27-28-20210902","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/bja\/56.2.103","article-title":"Prevention of nitrous oxide-induced megaloblastic changes in bone marrow using folinic acid.","volume":"56","author":"Amos","year":"1984","journal-title":"Br J Anaesth"},{"key":"R28-28-20210902","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/bja\/58.12.1469","article-title":"Megaloblastic bone marrow changes after repeated nitrous oxide anaesthesia: reversal with folinic acid.","volume":"58","author":"Nunn","year":"1986","journal-title":"Br J Anaesth"},{"key":"R29-28-20210902","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(82)92499-0","article-title":"Megaloblastic haemopoiesis after multiple short-term exposure to nitrous oxide.","volume":"1","author":"Nunn","year":"1982","journal-title":"Lancet"},{"key":"R30-28-20210902","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/00000542-198155060-00008","article-title":"Human bone marrow biochemical function and megaloblastic hematopoiesis after nitrous oxide anesthesia.","volume":"55","author":"OSullivan","year":"1981","journal-title":"Anesthesiology"},{"key":"R31-28-20210902","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1983.tb02011.x","article-title":"Studies on the haemopoietic toxicity of nitrous oxide in man.","volume":"53","author":"Skacel","year":"1983","journal-title":"Br J Haematol"},{"key":"R32-28-20210902","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.anes.0000270723.30772.da","article-title":"Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial.","volume":"107","author":"Myles","year":"2007","journal-title":"Anesthesiology"},{"key":"R33-28-20210902","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/0310057X0403200202","article-title":"A review of the risks and benefits of nitrous oxide in current anaesthetic practice.","volume":"32","author":"Myles","year":"2004","journal-title":"Anaesth Intensive Care"},{"key":"R34-28-20210902","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-2002-36768","article-title":"Homocysteine and coronary heart disease.","volume":"2","author":"Clarke","year":"2002","journal-title":"Semin Vasc Med"},{"key":"R35-28-20210902","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM199707243370403","article-title":"Plasma homocysteine levels and mortality in patients with coronary artery disease.","volume":"337","author":"Nygard","year":"1997","journal-title":"N Engl J Med"},{"key":"R36-28-20210902","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1160\/TH03-02-0038","article-title":"Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children.","volume":"91","author":"Kosch","year":"2004","journal-title":"Thromb Haemost"},{"key":"R37-28-20210902","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.arcmed.2007.01.004","article-title":"Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction.","volume":"38","author":"Abahji","year":"2007","journal-title":"Arch Med Res"},{"key":"R38-28-20210902","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0140-6736(05)78090-9","article-title":"Acute hyperhomocysteinaemia and endothelial dysfunction.","volume":"351","author":"Chambers","year":"1998","journal-title":"Lancet"},{"key":"R39-28-20210902","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/ALN.0b013e31818629db","article-title":"Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function.","volume":"109","author":"Myles","year":"2008","journal-title":"Anesthesiology"},{"key":"R40-28-20210902","first-page":"1073","article-title":"Nitrous oxide-induced increased homocysteine concentrations are associated with increased postoperative myocardial ischemia in patients undergoing carotid endarterectomy.","volume":"91","author":"Badner","year":"2000","journal-title":"Anesth Analg"},{"key":"R41-28-20210902","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1046\/j.1365-2044.2001.01374-2.x","article-title":"Effects of surgical stress and nitrous oxide anaesthesia on peri-operative plasma levels of total homocysteine: a randomised, controlled study in general surgery.","volume":"56","author":"Foschi","year":"2001","journal-title":"Anaesthesia"},{"key":"R42-28-20210902","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1365-2044.2010.06375.x","article-title":"Pre-operative vitamin B infusion and prevention of nitrous oxide-induced homocysteine increase.","volume":"65","author":"Rao","year":"2010","journal-title":"Anaesthesia"}],"container-title":["Anesthesia &amp; Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ANE.0b013e31822402f5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:16:58Z","timestamp":1786112218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-201110000-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e31822402f5","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}