{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:58:07Z","timestamp":1791935887602,"version":"4.3.4"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1213\/ane.0b013e318241f68a","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T04:38:45Z","timestamp":1326861525000},"page":"284-296","source":"Crossref","is-referenced-by-count":206,"title":["A Placebo- and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056)"],"prefix":"10.1213","volume":"115","author":[{"given":"Hugh R.","family":"Wiltshire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin J.","family":"Kilpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Tilbrook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Borkett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20210902","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/01.anes.0000267503.85085.c0","article-title":"CNS 7056: a novel ultra-short-acting benzodiazepine.","volume":"107","author":"Kilpatrick","year":"2007","journal-title":"Anesthesiology"},{"key":"R2-14-20210902","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1213\/ANE.0b013e31823f0c28","article-title":"A placebo- and midazolam-controlled phase I single ascending dose study evaluating the safety, pharmacokinetics and pharmacodynamics of remizolam (CNS 7056): Part I. Safety, efficacy, and basic pharmacokinetics.","volume":"115","author":"Antonik","year":"2012","journal-title":"Anesth Analg"},{"key":"R3-14-20210902","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1067\/mge.2000.107284","article-title":"Bispectral index monitoring of sedation during endoscopy.","volume":"52","author":"Bower","year":"2000","journal-title":"Gastrointest Endosc"},{"key":"R6-14-20210902","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00000542-199203000-00003","article-title":"Context-sensitive half-time in multicomponent pharmacokinetic models for intravenous anesthetic drugs.","volume":"76","author":"Hughes","year":"1992","journal-title":"Anesthesiology"},{"key":"R7-14-20210902","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/bja\/aeh089","article-title":"The two-compartment recirculatory pharmacokinetic model: an introduction to recirculatory pharmacokinetic concepts.","volume":"92","author":"Upton","year":"2004","journal-title":"Br J Anaesth"}],"container-title":["Anesthesia &amp; Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ANE.0b013e318241f68a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:17:55Z","timestamp":1786112275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-201208000-00014"}},"subtitle":["Part II. Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation"],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e318241f68a","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717955268.793460421","asserted-by":"object"}]},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}