{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:34:51Z","timestamp":1792679691336,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1213\/ane.0b013e3182691898","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T03:35:17Z","timestamp":1346988917000},"page":"1071-1077","source":"Crossref","is-referenced-by-count":52,"title":["Inhaled Fentanyl Aerosol in Healthy Volunteers"],"prefix":"10.1213","volume":"115","author":[{"given":"David B.","family":"MacLeod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf S.","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Spyker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James V.","family":"Cassella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Yuen","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong J.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20210902","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2165\/00003495-200868070-00003","article-title":"Management of breakthrough pain in patients with cancer.","volume":"68","author":"William","year":"2008","journal-title":"Drugs"},{"key":"R3-13-20210902","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1054\/bjoc.2001.1680","article-title":"Morphine and alternative opioids in cancer pain: the EAPC recommendations.","volume":"84","author":"Hanks","year":"2001","journal-title":"Br J Cancer"},{"key":"R4-13-20210902","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/01.ajp.0000210932.27945.4a","article-title":"A randomized, placebo-controlled study of fentanyl buccal tablet for breakthrough pain in opioid-treated patients with cancer.","volume":"22","author":"Portenoy","year":"2006","journal-title":"Clin J Pain"},{"key":"R5-13-20210902","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.clinthera.2007.04.007","article-title":"Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled study.","volume":"29","author":"Simpson","year":"2007","journal-title":"Clin Ther"},{"key":"R6-13-20210902","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00137696-200604010-00001","article-title":"Fentanyl effervescent buccal tablets: enhanced buccal absorption.","volume":"4","author":"Durfee","year":"2006","journal-title":"Am J Drug Deliv"},{"key":"R7-13-20210902","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.addr.2006.07.013","article-title":"Pulmonary delivery of opioids as pain therapeutics.","volume":"58","author":"Farr","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"R8-13-20210902","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1365-2044.1991.tb09862.x","article-title":"Inhaled nebulised fentanyl for postoperative analgesia.","volume":"46","author":"Higgins","year":"1991","journal-title":"Anaesthesia"},{"key":"R9-13-20210902","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2044.1990.tb14331.x","article-title":"Inhaled fentanyl as a method of analgesia.","volume":"45","author":"Worsley","year":"1990","journal-title":"Anaesthesia"},{"key":"R10-13-20210902","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/thx.50.6.639","article-title":"Aerosol deposition in the human lung following administration from a microprocessor controlled pressurised metered dose inhaler.","volume":"50","author":"Farr","year":"1995","journal-title":"Thorax"},{"key":"R11-13-20210902","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrd2153","article-title":"Inhaling medicines: delivering drugs to the body through the lungs.","volume":"6","author":"Patton","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"R12-13-20210902","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1046\/j.1365-2125.2003.01893.x","article-title":"Pulmonary drug delivery: part II. the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications.","volume":"56","author":"Labiris","year":"2003","journal-title":"Br J Clin Pharmacol"},{"key":"R13-13-20210902","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1046\/j.1365-2125.2003.01892.x","article-title":"Pulmonary drug delivery: part I. physiological factors affecting therapeutic effectiveness of aerosolized medications.","volume":"56","author":"Labiris","year":"2003","journal-title":"Br J Clin Pharmacol"},{"key":"R14-13-20210902","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/bja\/61.2.228","article-title":"Absorption and bioavailability of nebulized morphine.","volume":"61","author":"Chrubasik","year":"1988","journal-title":"Br J Anaesth"},{"key":"R15-13-20210902","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/00000542-200009000-00009","article-title":"Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers.","volume":"93","author":"Dershwitz","year":"2000","journal-title":"Anesthesiology"},{"key":"R16-13-20210902","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1124\/dmd.106.010652","article-title":"Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs.","volume":"35","author":"Avram","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"R17-13-20210902","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/clpt.2008.184","article-title":"The pharmacokinetics and bioavailability of prochlorperazine delivered as a thermally generated aerosol in a single breath to volunteers.","volume":"85","author":"Avram","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"R18-13-20210902","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1002\/jps.20694","article-title":"Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation.","volume":"95","author":"Rabinowitz","year":"2006","journal-title":"J Pharm Sci"},{"key":"R19-13-20210902","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1124\/jpet.103.062893","article-title":"Fast onset medications through thermally generated aerosols.","volume":"309","author":"Rabinowitz","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"R20-13-20210902","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.4155\/fmc.11.122","article-title":"Consistency of dosing with the Staccato System: in vitro and in vivo correlation.","volume":"3","author":"Myers","year":"2011","journal-title":"Future Med Chem"},{"key":"R21-13-20210902","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/00000542-200304000-00011","article-title":"Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.","volume":"98","author":"Ibrahim","year":"2003","journal-title":"Anesthesiology"},{"key":"R22-13-20210902","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2125.1998.00035.x","article-title":"Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery.","volume":"46","author":"Mather","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"R23-13-20210902","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00000542-199508000-00007","article-title":"Pharmacokinetics of inhaled liposome-encapsulated fentanyl.","volume":"83","author":"Hung","year":"1995","journal-title":"Anesthesiology"},{"key":"R24-13-20210902","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2165\/00003088-200645080-00006","article-title":"Comparison of equivalent doses of fentanyl buccal tablets and arteriovenous differences in fentanyl pharmacokinetics.","volume":"45","author":"Darwish","year":"2006","journal-title":"Clin Pharmacokinet"},{"key":"R25-13-20210902","first-page":"22","article-title":"A randomized pharmacokinetic study of AD 923 (Fentanyl Sublingual Spray) vs. Actiq (OTFC) and Fentanyl Citrate injection in healthy human volunteers.","volume":"9","author":"Tansley","year":"2008","journal-title":"J Pain Symptom Manage"}],"container-title":["Anesthesia & Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ANE.0b013e3182691898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:19:21Z","timestamp":1786112361000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-201211000-00013"}},"subtitle":["Pharmacokinetics and Pharmacodynamics"],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e3182691898","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717962959.793465016","asserted-by":"object"}]},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}