{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:21:38Z","timestamp":1786123298465,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1213\/ane.0b013e31826e0fe0","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T06:56:47Z","timestamp":1354863407000},"page":"216-223","source":"Crossref","is-referenced-by-count":12,"title":["A Pan-Caspase Inhibitor Reduces Myocyte Apoptosis and Neuropathic Pain in Rats with Chronic Constriction Injury of the Sciatic Nerve"],"prefix":"10.1213","volume":"116","author":[{"given":"Georg","family":"Gradl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Herlyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Finke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Gierer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mittlmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vollmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-28-20210902","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jpain.2005.11.008","article-title":"The epidemiology of chronic pain of predominantly neuropathic origin: results from a general population survey.","volume":"7","author":"Torrance","year":"2006","journal-title":"J Pain"},{"key":"R2-28-20210902","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3959(95)00110-E","article-title":"Reflex sympathetic dystrophy: changing concepts and taxonomy.","volume":"63","author":"StantonHicks","year":"1995","journal-title":"Pain"},{"key":"R4-28-20210902","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"R5-28-20210902","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pain.2004.08.007","article-title":"In vivo evidence for apoptosis, but not inflammation in the hindlimb muscle of neuropathic rats.","volume":"112","author":"Gradl","year":"2004","journal-title":"Pain"},{"key":"R6-28-20210902","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neulet.2006.04.007","article-title":"Exaggeration of tissue trauma induces signs and symptoms of acute CRPS I, however displays distinct differences to experimental CRPS II.","volume":"402","author":"Gradl","year":"2006","journal-title":"Neurosci Lett"},{"key":"R7-28-20210902","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.CIR.97.3.276","article-title":"Attenuation of ischemiareperfusion injury in rats by a caspase inhibitor.","volume":"97","author":"Yaoita","year":"1998","journal-title":"Circulation"},{"key":"R8-28-20210902","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1152\/ajpgi.00275.2003","article-title":"Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia.","volume":"286","author":"Eipel","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R9-28-20210902","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0304-3959(90)90022-6","article-title":"Further evidence for pain-related behaviours in a model of unilateral peripheral mononeuropathy.","volume":"41","author":"Attal","year":"1990","journal-title":"Pain"},{"key":"R10-28-20210902","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw.","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"R11-28-20210902","first-page":"335","article-title":"A new preparation of the rat extensor digitorum longus muscle for intravital investigation of the microcirculation.","volume":"10","author":"Tyml","year":"1991","journal-title":"Int J Microcirc Clin Exp"},{"key":"R12-28-20210902","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/jor.1100170509","article-title":"In vivo analysis of microcirculation following closed soft-tissue injury.","volume":"17","author":"Schaser","year":"1999","journal-title":"J Orthop Res"},{"key":"R13-28-20210902","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/01.shk.0000174022.33182.4b","article-title":"Supernatant of traumatized muscle induces inflammation and pain, but not microcirculatory perfusion failure and apoptotic cell death.","volume":"24","author":"Gradl","year":"2005","journal-title":"Shock"},{"key":"R14-28-20210902","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0006-8993(96)01026-8","article-title":"Neuropeptide changes persist in spinal cord despite resolving hyperalgesia in a rat model of mononeuropathy.","volume":"743","author":"Munglani","year":"1996","journal-title":"Brain Res"},{"key":"R15-28-20210902","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1046\/j.1460-9568.1998.00260.x","article-title":"Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons.","volume":"10","author":"Azkue","year":"1998","journal-title":"Eur J Neurosci"},{"key":"R16-28-20210902","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00001756-200201210-00024","article-title":"Apoptotic genes expression in the lumbar dorsal horn in a model neuropathic pain in rat.","volume":"13","author":"Maione","year":"2002","journal-title":"Neuroreport"},{"key":"R17-28-20210902","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1523\/JNEUROSCI.1526-05.2005","article-title":"Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.","volume":"25","author":"Scholz","year":"2005","journal-title":"J Neurosci"},{"key":"R18-28-20210902","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pain.2004.06.011","article-title":"Lack of evidence for significant neuronal loss in laminae IIII of the spinal dorsal horn of the rat in the chronic constriction injury model.","volume":"111","author":"Polgar","year":"2004","journal-title":"Pain"},{"key":"R19-28-20210902","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1523\/JNEUROSCI.1490-05.2005","article-title":"Loss of neurons from laminas IIII of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain.","volume":"25","author":"Polgar","year":"2005","journal-title":"J Neurosci"},{"key":"R20-28-20210902","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/nbdi.2002.0521","article-title":"Pathways leading to apoptotic neurodegeneration following trauma to the developing rat brain.","volume":"11","author":"FelderhoffMueser","year":"2002","journal-title":"Neurobiol Dis"},{"key":"R21-28-20210902","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1161\/01.STR.0000141162.29864.e9","article-title":"Neurovascular protection reduces early brain injury after subarachnoid hemorrhage.","volume":"35","author":"Park","year":"2004","journal-title":"Stroke"},{"key":"R22-28-20210902","doi-asserted-by":"crossref","first-page":"32608","DOI":"10.1074\/jbc.273.49.32608","article-title":"Inhibition of human caspases by peptide-based and macromolecular inhibitors.","volume":"273","author":"GarciaCalvo","year":"1998","journal-title":"J Biol Chem"},{"key":"R23-28-20210902","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/00000542-200607000-00024","article-title":"Permeability of injured and intact nerves and dorsal root ganglia.","volume":"105","author":"Abram","year":"2006","journal-title":"Anesthesiology"},{"key":"R24-28-20210902","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/glia.20910","article-title":"Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons.","volume":"58","author":"Schaeffer","year":"2010","journal-title":"Glia"},{"key":"R25-28-20210902","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3171\/jns.1979.51.2.0178","article-title":"Percussive injury to peripheral nerve in rats.","volume":"51","author":"Richardson","year":"1979","journal-title":"J Neurosurg"},{"key":"R26-28-20210902","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1152\/japplphysiol.00066.2007","article-title":"Granulocyte-colony stimulating factor enhances muscle proliferation and strength following skeletal muscle injury in rats.","volume":"103","author":"Stratos","year":"2007","journal-title":"J Appl Physiol"},{"key":"R27-28-20210902","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1600-0404.1997.tb00302.x","article-title":"DNAfragmentation and apoptosisrelated proteins of muscle cells in motor neuron disorders.","volume":"96","author":"Tews","year":"1997","journal-title":"Acta Neurol Scand"},{"key":"R28-28-20210902","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/jsre.1998.5504","article-title":"A regenerative change during muscle adaptation to denervation in rats.","volume":"81","author":"Yoshimura","year":"1999","journal-title":"J Surg Res"},{"key":"R29-28-20210902","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1152\/japplphysiol.90932.2008","article-title":"Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy.","volume":"107","author":"Plant","year":"2009","journal-title":"J Appl Physiol"},{"key":"R30-28-20210902","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/eji.200424904","article-title":"Mini review: a pivotal role for innate immunity in the clearance of apoptotic cells.","volume":"34","author":"Roos","year":"2004","journal-title":"Eur J Immunol"}],"container-title":["Anesthesia &amp; Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1213\/ANE.0b013e31826e0fe0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:19:53Z","timestamp":1786112393000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000539-201301000-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1213\/ane.0b013e31826e0fe0","relation":{},"ISSN":["0003-2999"],"issn-type":[{"value":"0003-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}