{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:28:33Z","timestamp":1758817713346,"version":"3.37.3"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,11,1]]},"DOI":"10.1227\/00006123-199211000-00016","type":"journal-article","created":{"date-parts":[[2010,5,30]],"date-time":"2010-05-30T09:06:09Z","timestamp":1275210369000},"page":"929-934","source":"Crossref","is-referenced-by-count":30,"title":["The Effect of the 21-Aminosteroid U74006F in a Rabbit Model of Thromboembolic Stroke"],"prefix":"10.1227","volume":"31","author":[{"given":"James T.","family":"Wilson","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery (JTW, MMB, SR, CEG), and Department of Medical Biostatistics (TLM), University of Vermont, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin M.","family":"Bednar","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery (JTW, MMB, SR, CEG), and Department of Medical Biostatistics (TLM), University of Vermont, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy L.","family":"McAuliffe","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery (JTW, MMB, SR, CEG), and Department of Medical Biostatistics (TLM), University of Vermont, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Raymond","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery (JTW, MMB, SR, CEG), and Department of Medical Biostatistics (TLM), University of Vermont, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cordell E.","family":"Gross","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery (JTW, MMB, SR, CEG), and Department of Medical Biostatistics (TLM), University of Vermont, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"key\n\t\t\t\t20180502065637_R1-16","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/01.STR.12.6.723","article-title":"Thresholds in cerebral ischemia\u2014 The ischemic penumbra","volume":"12","author":"Astrup","year":"1981","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R2-16","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/01.STR.17.6.1304","article-title":"Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats","volume":"17","author":"Bederson","year":"1986","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R3-16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/01.RES.57.1.131","article-title":"Nafazatrom-induced salvage of ischemic myocardium in anesthetized dogs is mediated through inhibition of neutrophil function","volume":"57","author":"Bednar","year":"1985","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180502065637_R4-16","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1161\/01.STR.21.12.1705","article-title":"tPA reduces brain injury in a rabbit model of thromboembolic stroke","volume":"21","author":"Bednar","year":"1990","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R5-16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.STR.19.1.28","article-title":"Evolving focal cerebral ischemia in cats: Spatial correlation of nuclear magnetic resonance imaging, cerebral blood flow, tetrazolium staining, and histopathology","volume":"19","author":"Bose","year":"1988","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R6-16","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1016\/S0021-9258(18)60979-2","article-title":"Novel 21-aminosteroids as potent inhibitors of iron- dependent lipid peroxidation","volume":"262","author":"Braughler","year":"1987","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180502065637_R7-16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-3565(25)24416-0","article-title":"A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT- 20) cells","volume":"244","author":"Braughler","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20180502065637_R8-16","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/jcbfm.1987.127","article-title":"Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury","volume":"7","author":"Busto","year":"1987","journal-title":"J Cereb Blood Flow Metab"},{"key":"key\n\t\t\t\t20180502065637_R9-16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3940(88)90132-2","article-title":"Oxygen free radical involvement in ischemia and reperfusion injury to brain","volume":"88","author":"Cao","year":"1988","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t20180502065637_R10-16","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1161\/01.STR.20.9.1241","article-title":"Modification of acute focal ischemia in rabbits by poloxamer 188","volume":"20","author":"Colbassani","year":"1989","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R11-16","first-page":"91","article-title":"The free radical pathology in microcirculation in the major central nervous system disorders","volume":"492","author":"Demopoulos","year":"1980","journal-title":"Acta Physiol Scand [Suppl]"},{"key":"key\n\t\t\t\t20180502065637_R12-16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0002-8703(81)90226-X","article-title":"Early phase acute myocardial infarct size quantification: Validation of the triphenyltetrazolium chloride tissue enzyme staining technique","volume":"101","author":"Fishbein","year":"1981","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20180502065637_R13-16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/01.STR.9.5.445","article-title":"Free radicals in cerebral ischemia","volume":"9","author":"Flamm","year":"1978","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R14-16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1161\/01.STR.19.3.340","article-title":"Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F","volume":"19","author":"Hall","year":"1988","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R15-16","first-page":"III-83","article-title":"Nonsteroidal lazaroid U78517F in models of focal and global ischemia","volume":"21[suppl III]","author":"Hall","year":"1990","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R16-16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1227\/00006123-199007000-00001","article-title":"The molecular basis of brain injury and brain edema: The role of oxygen free radicals","volume":"27","author":"Ikeda","year":"1990","journal-title":"Neurosurgery"},{"key":"key\n\t\t\t\t20180502065637_R17-16","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/01.STR.20.6.788","article-title":"Effect of indomethacin and a free radical scavenger on cerebral blood flow and edema after cerebral artery occlusion in cats","volume":"20","author":"Johshita","year":"1989","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R18-16","doi-asserted-by":"crossref","first-page":"202A","DOI":"10.1203\/00006450-198704010-00214","article-title":"Reperfusion induced free radical formation following global ischemia","volume":"21","author":"Kirsch","year":"1987","journal-title":"Pediatr Res"},{"key":"key\n\t\t\t\t20180502065637_R19-16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1471-4159.1984.tb09728.x","article-title":"Potentiation of lipid peroxides by ischemia in rat brain","volume":"42","author":"Kogure","year":"1984","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20180502065637_R20-16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3171\/jns.1986.65.4.0517","article-title":"Discrepancies among CT, histological, and blood-brain barrier findings in early cerebral ischemia","volume":"65","author":"Kuroiwa","year":"1986","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t20180502065637_R21-16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3171\/jns.1989.70.1.0073","article-title":"Nonhyperemic blood flow restoration and brain edema in experimental focal cerebral ischemia","volume":"70","author":"Kuroiwa","year":"1989","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t20180502065637_R22-16","first-page":"417","article-title":"A new class of compounds for stroke and trauma: Effects of 21-aminosteroids on lipid peroxidation","volume":"38","author":"McCall","year":"1987","journal-title":"Acta Anaesthesiol Belg"},{"key":"key\n\t\t\t\t20180502065637_R23-16","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/bja\/47.11.1149","article-title":"Circulatory responses to ketamine: Dependence on respiratory pattern and background anaesthesia in the rabbit","volume":"47","author":"McGrath","year":"1975","journal-title":"Br J Anaesth"},{"key":"key\n\t\t\t\t20180502065637_R24-16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/01.STR.19.3.372","article-title":"Brain eicosanoid levels in spontaneously hypertensive rats after ischemia with reperfusion: Leukotriene C4 as a possible cause of cerebral edema","volume":"19","author":"Minamisawa","year":"1988","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R25-16","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1212\/WNL.28.8.754","article-title":"The Harvard Cooperative Stroke Registry: A prospective registry","volume":"28","author":"Mohr","year":"1978","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180502065637_R26-16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/01.STR.9.2.143","article-title":"Cerebral blood flow determined by hydrogen clearance during middle cerebral artery occlusion in unanesthetized monkeys","volume":"9","author":"Morawetz","year":"1978","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R27-16","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1161\/01.CIR.67.5.1016","article-title":"Reduction in the extent of ischemic myocardial injury by neutrophil depletion in the dog","volume":"67","author":"Romson","year":"1983","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180502065637_R28-16","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/01.STR.4.4.674","article-title":"Correlation of continuous electroencephalograms with cerebral blood flow measurements during carotid endarterectomy","volume":"4","author":"Sharbrough","year":"1973","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R29-16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/01.STR.21.1.107","article-title":"Continuous lidocaine infusion and focal feline cerebral ischemia","volume":"21","author":"Shokunbi","year":"1990","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R30-16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF01907405","article-title":"A comparison of two methods for estimating the area at risk in experimental myocardial infarction","volume":"81","author":"Vanhaecke","year":"1986","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t20180502065637_R31-16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1471-4159.1984.tb09728.x","article-title":"Lipid peroxidation in vivo induced by reversible global ischemia in rat brain","volume":"42","author":"Watson","year":"1984","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20180502065637_R32-16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1042\/bj1980125","article-title":"Hydroxyl radical production in body fluids: Roles of metal ions, ascorbate, and superoxide","volume":"198","author":"Winterbourn","year":"1981","journal-title":"J Biochem (Tokyo)"},{"key":"key\n\t\t\t\t20180502065637_R33-16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/01.STR.11.5.552","article-title":"Hydrogen clearance of blood flow: A review of technique and polarographic principles","volume":"11","author":"Young","year":"1980","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R34-16","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1161\/01.STR.19.8.1013","article-title":"21-Aminosteroid reduces ion shifts and edema in the rat middle cerebral artery occlusion model of regional ischemia","volume":"19","author":"Young","year":"1988","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R35-16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1161\/01.STR.20.3.367","article-title":"Protective effect of a 21-aminosteroid on the blood-brain barrier following subarachnoid hemorrhage in rats","volume":"20","author":"Zuccarello","year":"1989","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R36-16","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1073\/pnas.84.5.1404","article-title":"Direct measurement of free radical generation following reperfusion of ischemic myocardium","volume":"84","author":"Zweier","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180502065637_R37-16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1161\/01.STR.12.2.228","article-title":"Embolism distal to stenosis of the middle cerebral artery","volume":"12","author":"Adams","year":"1981","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R38-16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/01.STR.7.1.14","article-title":"A classification of experimental models of brain ischemia","volume":"7","author":"Molinari","year":"1976","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R39-16","first-page":"57\u2013","article-title":"Experimental models of ischemic stroke, in Barnett HJ, Mohr JP, Stein B, Yatsu FM (eds)","author":"Molinari","year":"1985","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20180502065637_R40-16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-642-76439-4_12","article-title":"Thrombolytic therapy in acute ischemic stroke: Relevance and limitations of animal models, in Hacke W, del Zoppo GJ, Hirschberg M (eds)","author":"Molinari","year":"1991","journal-title":"Thrombolytic Therapy in Acute Ischemic Stroke"},{"key":"key\n\t\t\t\t20180502065637_R41-16","first-page":"2","article-title":"A new model of cerebral embolic ischemia using autologous arterial thrombus","volume":"5","author":"Rigamonti","year":"1989","journal-title":"BNI Quart"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/31\/5\/929\/24598494\/0006123-199211000-00016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:59:00Z","timestamp":1740135540000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.lww.com\/00006123-199211000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11,1]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,11,1]]}},"URL":"https:\/\/doi.org\/10.1227\/00006123-199211000-00016","relation":{},"ISSN":["1524-4040","0148-396X"],"issn-type":[{"type":"electronic","value":"1524-4040"},{"type":"print","value":"0148-396X"}],"subject":[],"published-other":{"date-parts":[[1992,11]]},"published":{"date-parts":[[1992,11,1]]}}}