{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:38:52Z","timestamp":1789943932819,"version":"4.0.1"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1227\/neu.0b013e3181ec7b71","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T06:15:17Z","timestamp":1285654517000},"page":"998-1019","source":"Crossref","is-referenced-by-count":40,"title":["Global Gene Expression Profiling and Tissue Microarray Reveal Novel Candidate Genes and Down-Regulation of the Tumor Suppressor Gene CAV1 in Sporadic Vestibular Schwannomas"],"prefix":"10.1227","volume":"67","author":[{"given":"Mads","family":"Aarhus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ove","family":"Bruland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hege Aase","family":"S\u00e6tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre J","family":"Mork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Lund-Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per M","family":"Knappskog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"18","key":"R2-29-20230406","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1056\/NEJMoa070972","article-title":"Incidental findings on brain MRI in the general population.","volume":"357","author":"Vernooij","year":"2007","journal-title":"N Engl J Med"},{"issue":"8","key":"R3-29-20230406","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1258\/0022215041917989","article-title":"Increasing annual incidence of vestibular schwannoma and age at diagnosis.","volume":"118","author":"Stangerup","year":"2004","journal-title":"J Laryngol Otol"},{"issue":"5","key":"R4-29-20230406","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0092-8674(93)90406-G","article-title":"A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.","volume":"72","author":"Trofatter","year":"1993","journal-title":"Cell"},{"issue":"6","key":"R5-29-20230406","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/hmg\/3.6.885","article-title":"Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas.","volume":"3","author":"Sainz","year":"1994","journal-title":"Hum Mol Genet"},{"issue":"2","key":"R6-29-20230406","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/MAO.0b013e3181be6478","article-title":"Deregulated genes in sporadic vestibular schwannomas.","volume":"31","author":"Caye-Thomasen","year":"","journal-title":"Otol Neurotol"},{"issue":"6","key":"R7-29-20230406","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2990.2006.00769.x","article-title":"Differential gene expression between human schwannoma and control Schwann cells.","volume":"32","author":"Hanemann","year":"2006","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"1","key":"R8-29-20230406","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/mao.0b013e31816021f7","article-title":"Phosphatidylinositol 3-Kinase\/AKT pathway activation in human vestibular schwannoma.","volume":"29","author":"Jacob","year":"2008","journal-title":"Otol Neurotol"},{"issue":"5","key":"R9-29-20230406","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/00129492-200209000-00022","article-title":"cDNA microarray analysis of vestibular schwannomas.","volume":"23","author":"Welling","year":"2002","journal-title":"Otol Neurotol"},{"issue":"2","key":"R10-29-20230406","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00701-003-0183-2","article-title":"Plasminogen activation in neurofibromatosis 2-associated and sporadic schwannomas.","volume":"146","author":"Siren","year":"2004","journal-title":"Acta Neurochir (Wien)"},{"issue":"3","key":"R11-29-20230406","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11060-008-9569-6","article-title":"Microarray analysis reveals down-regulation of the tumour suppressor gene WWOX and up-regulation of the oncogene TYMS in intracranial sporadic meningiomas.","volume":"88","author":"Aarhus","year":"2008","journal-title":"J Neurooncol"},{"issue":"4","key":"R12-29-20230406","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/bioinformatics\/17.4.369","article-title":"J-Express: exploring gene expression data using Java.","volume":"17","author":"Dysvik","year":"2001","journal-title":"Bioinformatics"},{"issue":"9","key":"R13-29-20230406","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response.","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"R14-29-20230406","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1750-3639.2002.tb00426.x","article-title":"Tissue microarrays: applications in neuropathology research, diagnosis, and education.","volume":"12","author":"Wang","year":"2002","journal-title":"Brain Pathol"},{"issue":"6429","key":"R15-29-20230406","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/363515a0","article-title":"Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2.","volume":"363","author":"Rouleau","year":"1993","journal-title":"Nature"},{"issue":"6","key":"R16-29-20230406","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/S0002-9440(10)64335-0","article-title":"Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation.","volume":"162","author":"Capozza","year":"2003","journal-title":"Am J Pathol"},{"issue":"4","key":"R17-29-20230406","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10555-008-9160-9","article-title":"Caveolin-1 in tumor progression: the good, the bad and the ugly.","volume":"27","author":"Goetz","year":"2008","journal-title":"Cancer Metastasis Rev"},{"issue":"51","key":"R18-29-20230406","doi-asserted-by":"crossref","first-page":"15124","DOI":"10.1021\/bi0356348","article-title":"Caveolin-1 null (-\/-) mice show dramatic reductions in life span.","volume":"42","author":"Park","year":"2003","journal-title":"Biochemistry"},{"issue":"12","key":"R19-29-20230406","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.4161\/cc.4.12.2198","article-title":"Caveolin-1-deficient mice have an increased mammary stem cell population with upregulation of Wnt\/beta-catenin signaling.","volume":"4","author":"Sotgia","year":"2005","journal-title":"Cell Cycle"},{"issue":"3","key":"R20-29-20230406","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1091\/mbc.e02-08-0503","article-title":"Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.","volume":"14","author":"Williams","year":"2003","journal-title":"Mol Biol Cell"},{"issue":"23","key":"R21-29-20230406","doi-asserted-by":"crossref","first-page":"24745","DOI":"10.1074\/jbc.M402064200","article-title":"Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a\/CAV-1 in mammary epithelial cell hyperplasia.","volume":"279","author":"Williams","year":"2004","journal-title":"J Biol Chem"},{"issue":"49","key":"R22-29-20230406","doi-asserted-by":"crossref","first-page":"51630","DOI":"10.1074\/jbc.M409214200","article-title":"Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2\/9) secretion.","volume":"279","author":"Williams","year":"2004","journal-title":"J Biol Chem"},{"issue":"3","key":"R23-29-20230406","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1006\/bbrc.1999.1280","article-title":"Caveolin-1 expression and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures.","volume":"262","author":"Campbell","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"15","key":"R24-29-20230406","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1038\/sj.onc.1205300","article-title":"Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells.","volume":"21","author":"Fiucci","year":"2002","journal-title":"Oncogene"},{"issue":"11","key":"R25-29-20230406","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/sj.onc.1201661","article-title":"Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells.","volume":"16","author":"Lee","year":"1998","journal-title":"Oncogene"},{"issue":"11","key":"R26-29-20230406","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1021\/bi002787b","article-title":"Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism.","volume":"40","author":"Park","year":"2001","journal-title":"Biochemistry"},{"issue":"45","key":"R27-29-20230406","doi-asserted-by":"crossref","first-page":"13916","DOI":"10.1021\/bi001489b","article-title":"Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation.","volume":"39","author":"Razani","year":"2000","journal-title":"Biochemistry"},{"issue":"20","key":"R28-29-20230406","doi-asserted-by":"crossref","first-page":"9937","DOI":"10.1158\/0008-5472.CAN-06-0927","article-title":"Caveolin-1 (CAV1) is a target of EWS\/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewings sarcoma cells.","volume":"66","author":"Tirado","year":"2006","journal-title":"Cancer Res"},{"issue":"16","key":"R29-29-20230406","doi-asserted-by":"crossref","first-page":"7675","DOI":"10.1158\/0008-5472.CAN-06-4697","article-title":"Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling.","volume":"67","author":"Cantiani","year":"2007","journal-title":"Cancer Res"},{"issue":"1","key":"R30-29-20230406","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1098-1136(199907)27:1<39::AID-GLIA5>3.0.CO;2-#","article-title":"Caveolin-1 expression in Schwann cells.","volume":"27","author":"Mikol","year":"1999","journal-title":"Glia"},{"issue":"13","key":"R31-29-20230406","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1158\/0008-5472.CAN-07-5849","article-title":"Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma.","volume":"68","author":"Ammoun","year":"2008","journal-title":"Cancer Res"},{"issue":"2","key":"R34-29-20230406","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/sj.bjc.6604846","article-title":"Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers.","volume":"100","author":"Ohta","year":"2009","journal-title":"Br J Cancer"},{"issue":"6","key":"R35-29-20230406","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/gcc.20319","article-title":"Target genes of the WNT\/beta-catenin pathway in Wilms tumors.","volume":"45","author":"Zirn","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"issue":"4","key":"R36-29-20230406","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/mp.55.4.220","article-title":"Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma.","volume":"55","author":"Holcombe","year":"2002","journal-title":"Mol Pathol"},{"issue":"5","key":"R37-29-20230406","first-page":"1337","article-title":"Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma.","volume":"25","author":"Milovanovic","year":"2004","journal-title":"Int J Oncol"},{"issue":"1","key":"R38-29-20230406","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/path.2331","article-title":"Frizzled-1 is down-regulated in follicular thyroid tumours and modulates growth and invasiveness.","volume":"215","author":"Ulivieri","year":"2008","journal-title":"J Pathol"},{"issue":"1","key":"R39-29-20230406","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4161\/cc.8.1.7532","article-title":"Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells.","volume":"8","author":"Chen","year":"2009","journal-title":"Cell Cycle"},{"issue":"4797","key":"R40-29-20230406","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.3563490","article-title":"Identification of an amplified, highly expressed gene in a human glioma.","volume":"236","author":"Kinzler","year":"1987","journal-title":"Science"},{"issue":"8","key":"R41-29-20230406","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/mc.20516","article-title":"Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer.","volume":"48","author":"Seto","year":"2009","journal-title":"Mol Carcinog"},{"issue":"1","key":"R42-29-20230406","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4161\/cc.8.1.7532","article-title":"Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells.","volume":"8","author":"Chen","year":"2009","journal-title":"Cell Cycle"},{"issue":"3","key":"R43-29-20230406","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/73417","article-title":"Basal cell carcinomas in mice overexpressing Gli2 in skin.","volume":"24","author":"Grachtchouk","year":"2000","journal-title":"Nat Genet"},{"issue":"6","key":"R44-29-20230406","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1158\/1535-7163.MCT-07-2118","article-title":"Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma.","volume":"7","author":"Hegde","year":"2008","journal-title":"Mol Cancer Ther"},{"issue":"9","key":"R45-29-20230406","first-page":"3434","article-title":"Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.","volume":"6","author":"Nesterova","year":"2000","journal-title":"Clin Cancer Res"},{"issue":"6","key":"R46-29-20230406","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1530\/EJE-07-0819","article-title":"Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity.","volume":"158","author":"Vincent-Dejean","year":"2008","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"R47-29-20230406","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.amjoto.2007.08.003","article-title":"Transforming growth factor beta isoforms (TGF-beta1, TGF-beta2, TGF-beta3) messenger RNA expression in laryngeal cancer.","volume":"29","author":"Kapral","year":"2008","journal-title":"Am J Otolaryngol"},{"issue":"49","key":"R48-29-20230406","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1038\/onc.2008.232","article-title":"Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway.","volume":"27","author":"Katsuno","year":"2008","journal-title":"Oncogene"},{"issue":"7","key":"R49-29-20230406","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/onc.2008.454","article-title":"Transforming growth factor-beta1 is the predominant isoform required for breast cancer cell outgrowth in bone.","volume":"28","author":"Mourskaia","year":"2009","journal-title":"Oncogene"},{"issue":"7050","key":"R50-29-20230406","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature03799","article-title":"Genes that mediate breast cancer metastasis to lung.","volume":"436","author":"Minn","year":"2005","journal-title":"Nature"},{"issue":"5","key":"R51-29-20230406","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/ijc.23641","article-title":"A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma.","volume":"123","author":"Yao","year":"2008","journal-title":"Int J Cancer"},{"issue":"7","key":"R52-29-20230406","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1097\/MAO.0b013e31814b2285","article-title":"Cyclin D1 expression and histopathologic features in vestibular schwannomas.","volume":"28","author":"Lassaletta","year":"2007","journal-title":"Otol Neurotol"},{"issue":"1","key":"R53-29-20230406","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/mao.0b013e31815d4429","article-title":"ErbB and Nrg: potential molecular targets for vestibular schwannoma pharmacotherapy.","volume":"29","author":"Doherty","year":"2008","journal-title":"Otol Neurotol"},{"issue":"5","key":"R54-29-20230406","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/00129492-200409000-00024","article-title":"Correlation of growth factor receptor expression with clinical growth in vestibular schwannomas.","volume":"25","author":"OReilly","year":"2004","journal-title":"Otol Neurotol"},{"issue":"6","key":"R55-29-20230406","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2990.2006.00769.x","article-title":"Differential gene expression between human schwannoma and control Schwann cells.","volume":"32","author":"Hanemann","year":"2006","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"2","key":"R56-29-20230406","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11060-005-2886-0","article-title":"Aggressive vestibular schwannomas showing postoperative rapid growth - their association with decreased p27 expression.","volume":"75","author":"Seol","year":"2005","journal-title":"J Neurooncol"},{"issue":"1","key":"R57-29-20230406","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/mc.20150","article-title":"Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas.","volume":"45","author":"Dayalan","year":"2006","journal-title":"Mol Carcinog"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006123-201010000-00029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:42:01Z","timestamp":1786120921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006123-201010000-00029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1227\/neu.0b013e3181ec7b71","relation":{},"ISSN":["0148-396X"],"issn-type":[{"value":"0148-396X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}