{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:31:09Z","timestamp":1786123869604,"version":"build-2736575974"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1227\/neu.0b013e3181fa7032","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T22:09:02Z","timestamp":1290550142000},"page":"1655-1661","source":"Crossref","is-referenced-by-count":29,"title":["Changes in Tissue Substance P Levels in Patients With Carpal Tunnel Syndrome"],"prefix":"10.1227","volume":"67","author":[{"given":"Niyazi","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuray","family":"Erin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"T\u00fcz\u00fcner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"R1-31-20230327","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/jama.282.2.153","article-title":"Prevalence of carpal tunnel syndrome in a general population.","volume":"282","author":"Atroshi","year":"1999","journal-title":"JAMA"},{"issue":"6","key":"R2-31-20230327","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/rheumatology\/37.6.630","article-title":"Estimating the prevalence of delayed median nerve conduction in the general population.","volume":"37","author":"Ferry","year":"1998","journal-title":"Br J Rheumatol"},{"issue":"3","key":"R3-31-20230327","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/jhsu.2001.24972","article-title":"The prevalence and characteristics of nerve compression symptoms in the general population.","volume":"26","author":"Papanicolaou","year":"2001","journal-title":"J Hand Surg Am"},{"issue":"6","key":"R4-31-20230327","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.jhsa.2006.03.005","article-title":"Development and validation of diagnostic criteria for carpal tunnel syndrome.","volume":"31","author":"Graham","year":"2006","journal-title":"J Hand Surg Am"},{"issue":"11","key":"R5-31-20230327","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/(SICI)1097-4598(199911)22:11<1587::AID-MUS15>3.0.CO;2-M","article-title":"A relief maneuver in carpal tunnel syndrome.","volume":"22","author":"Manente","year":"1999","journal-title":"Muscle Nerve"},{"issue":"3","key":"R6-31-20230327","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pain.2006.01.034","article-title":"Extra-median spread of sensory symptoms in carpal tunnel syndrome suggests the presence of pain-related mechanisms.","volume":"122","author":"Zanette","year":"2006","journal-title":"Pain"},{"issue":"6","key":"R7-31-20230327","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1097\/01.prs.0000239593.55293.c7","article-title":"Changes in the functional structure of the tenosynovium in idiopathic carpal tunnel syndrome: a scanning electron microscope study.","volume":"118","author":"Ettema","year":"2006","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"R8-31-20230327","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0266-7681_86_90035-5","article-title":"The micropathology of the typical carpal tunnel syndrome.","volume":"11","author":"Faithfull","year":"1986","journal-title":"J Hand Surg Br"},{"issue":"6","key":"R9-31-20230327","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0363-5023(09)91053-X","article-title":"An analysis of the flexor synovium in idiopathic carpal tunnel syndrome: report of 625 cases.","volume":"17","author":"Kerr","year":"1992","journal-title":"J Hand Surg Am"},{"issue":"7","key":"R10-31-20230327","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1097\/01.PRS.0000122216.24878.1F","article-title":"A comparison of flexor tenosynovectomy, open carpal tunnel release, and open carpal tunnel release with flexor tenosynovectomy in the treatment of carpal tunnel syndrome.","volume":"113","author":"Ketchum","year":"2004","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"R11-31-20230327","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0363-5023(98)80009-9","article-title":"Histology of the transverse carpal ligament and flexor tenosynovium in idiopathic carpal tunnel syndrome.","volume":"23","author":"Nakamichi","year":"1998","journal-title":"J Hand Surg Am"},{"issue":"9","key":"R12-31-20230327","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1034\/j.1399-6576.2001.450912.x","article-title":"Neuropathic pain: what do we do with all these theories?","volume":"45","author":"Devor","year":"2001","journal-title":"Acta Anaesthesiol Scand"},{"issue":"3","key":"R13-31-20230327","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s004150200004","article-title":"Conservative treatment options for carpal tunnel syndrome: a systematic review of randomised controlled trials.","volume":"249","author":"Gerritsen","year":"2002","journal-title":"J Neurol"},{"issue":"7214","key":"R14-31-20230327","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1136\/bmj.319.7214.884","article-title":"Injection with methylprednisolone proximal to the carpal tunnel: randomised double blind trial.","volume":"319","author":"Dammers","year":"1999","journal-title":"BMJ"},{"issue":"1","key":"R15-31-20230327","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0143-4179(98)90015-4","article-title":"The tachykinin NK1 receptor, part II: distribution and pathophysiological roles.","volume":"32","author":"Quartara","year":"1998","journal-title":"Neuropeptides"},{"issue":"2","key":"R16-31-20230327","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/eujp.2000.0171","article-title":"Substance P.Crul BJ. Substance P.","volume":"4","author":"Snijdelaar","year":"2000","journal-title":"Eur J Pain"},{"issue":"2","key":"R17-31-20230327","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0306-4522(98)00488-6","article-title":"Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids.","volume":"89","author":"Hua","year":"1999","journal-title":"Neuroscience"},{"key":"R18-31-20230327","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1357-2725(01)00031-0","article-title":"Substance P.Geppetti P. Substance P.","volume":"33","author":"Harrison","year":"2001","journal-title":"Int J Biochem Cell Biol"},{"key":"R19-31-20230327","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1017\/S1092852900022628","article-title":"Understanding neuropathic pain.","volume":"10","author":"Zieglgansberger","year":"2005","journal-title":"CNS Spectr"},{"issue":"3","key":"R20-31-20230327","first-page":"176","article-title":"Effect of substance P released from peripheral nerve ending on endogenous expression of epidermal growth factor and its receptor in wound healing.","volume":"5","author":"Lai","year":"2002","journal-title":"Chin J Traumatol"},{"issue":"7","key":"R21-31-20230327","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1136\/ard.2004.029876","article-title":"Achilles tendinosis is associated with sprouting of substance P positive nerve fibres.","volume":"64","author":"Schubert","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"R22-31-20230327","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/BF02272149","article-title":"Innervation and neurokinin receptors during angiogenesis in the rat sponge granuloma.","volume":"28","author":"Walsh","year":"1996","journal-title":"Histochem J"},{"issue":"1-3","key":"R23-31-20230327","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.regpep.2008.10.006","article-title":"Differentiation of neuronal from non-neuronal substance P.","volume":"152","author":"Erin","year":"2009","journal-title":"Regul Pept"},{"issue":"8","key":"R24-31-20230327","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/j.1742-1241.2007.01453.x","article-title":"Effects of nimesulide on pain and on synovial fluid concentrations of substance P, interleukin-6 and interleukin-8 in patients with knee osteoarthritis: comparison with celecoxib.","volume":"61","author":"Bianchi","year":"2007","journal-title":"Int J Clin Pract"},{"issue":"8","key":"R25-31-20230327","first-page":"2622","article-title":"Substance P and its metabolites in normal human tears.","volume":"43","author":"Yamada","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"R26-31-20230327","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1365-2230.2004.01613.x","article-title":"NK-1 antagonist CP99994 inhibits stress-induced mast cell degranulation in rats.","volume":"29","author":"Erin","year":"2004","journal-title":"Clin Exp Dermatol"},{"issue":"3","key":"R28-31-20230327","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF02048482","article-title":"Neurophysiological classification of carpal tunnel syndrome: assessment of 600 symptomatic hands.","volume":"18","author":"Padua","year":"1997","journal-title":"Ital J Neurol Sci"},{"issue":"1-3","key":"R29-31-20230327","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.regpep.2008.10.007","article-title":"The effects of chronic low-dose capsaicin treatment on substance P levels.","volume":"153","author":"Erin","year":"2009","journal-title":"Regul Pept"},{"issue":"3","key":"R30-31-20230327","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1165\/ajrcmb\/3.3.191","article-title":"Immunohistochemical localization of peptide-containing nerves in human airways: age-related changes.","volume":"3","author":"Hislop","year":"1990","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"R31-31-20230327","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1600-0404.2004.00332.x","article-title":"The relationship between symptoms and electrophysiological detected compression of the median nerve at the wrist.","volume":"110","author":"de Campos","year":"2004","journal-title":"Acta Neurol Scand"},{"issue":"7000","key":"R32-31-20230327","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/325151a0","article-title":"Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input.","volume":"325","author":"Cook","year":"1987","journal-title":"Nature"},{"key":"R33-31-20230327","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/bja\/87.1.12","article-title":"Mechanisms of neuropathic pain.","volume":"87","author":"Bridges","year":"2001","journal-title":"Br J Anaesth"},{"issue":"1-3","key":"R34-31-20230327","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0165-0173(02)00186-8","article-title":"The whole body receptive field of dorsal horn multireceptive neurones.","volume":"40","author":"Le","year":"2002","journal-title":"Brain Res Brain Res Rev"},{"issue":"4","key":"R36-31-20230327","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1090-3801(03)00051-X","article-title":"Difficulties in stratifying neuropathic pain by mechanisms.","volume":"7","author":"Hansson","year":"2003","journal-title":"Eur J Pain"},{"issue":"1-2","key":"R37-31-20230327","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0304-3959(00)00243-8","article-title":"Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats.","volume":"86","author":"Malan","year":"2000","journal-title":"Pain"},{"issue":"3","key":"R38-31-20230327","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0304-3959(01)00354-2","article-title":"A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.","volume":"94","author":"Chacur","year":"2001","journal-title":"Pain"},{"issue":"1","key":"R39-31-20230327","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0091-3057(03)00187-4","article-title":"Functional role of exogenous administration of substance P in chronic constriction injury model of neuropathic pain in gerbils.","volume":"76","author":"Meert","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"issue":"1-2","key":"R40-31-20230327","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0006-8993(96)00619-1","article-title":"Localization and activation of substance P receptors in unmyelinated axons of rat glabrous skin.","volume":"734","author":"Carlton","year":"1996","journal-title":"Brain Res"},{"issue":"1","key":"R41-31-20230327","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0304-3959(89)90078-X","article-title":"Substance P and peripheral inflammatory hyperalgesia.","volume":"38","author":"Nakamura-Craig","year":"1989","journal-title":"Pain"},{"issue":"2","key":"R42-31-20230327","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.expneurol.2004.09.011","article-title":"The effect of substance P on the spontaneous discharge from injured inferior alveolar nerve fibres in the ferret.","volume":"191","author":"Smith","year":"2005","journal-title":"Exp Neurol"},{"issue":"2","key":"R43-31-20230327","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0165-5728(97)00201-4","article-title":"Detection of substance P immunoreactivity in human peripheral leukocytes.","volume":"82","author":"De","year":"1998","journal-title":"J Neuroimmunol"},{"issue":"11","key":"R44-31-20230327","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.4049\/jimmunol.159.11.5654","article-title":"Human monocytes and macrophages express substance P and neurokinin-1 receptor.","volume":"159","author":"Ho","year":"1997","journal-title":"J Immunol"},{"issue":"1-2","key":"R45-31-20230327","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0022-1759(99)00120-9","article-title":"Quantification of substance P mRNA in human mononuclear phagocytes and lymphocytes using a mimic-based RT-PCR.","volume":"230","author":"Lai","year":"1999","journal-title":"J Immunol Methods"},{"issue":"12","key":"R46-31-20230327","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1002\/(SICI)1521-4141(199912)29:12<3815::AID-IMMU3815>3.0.CO;2-#","article-title":"Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation.","volume":"29","author":"Lambrecht","year":"1999","journal-title":"Eur J Immunol"},{"issue":"5","key":"R47-31-20230327","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0196-9781(89)90175-7","article-title":"Identification of immunoreactive substance P in human and other mammalian endothelial cells.","volume":"10","author":"Linnik","year":"1989","journal-title":"Peptides"},{"issue":"1-3","key":"R48-31-20230327","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.regpep.2005.09.024","article-title":"Inhibition of substance P activity prevents stress-induced bladder damage.","volume":"133","author":"Ercan","year":"2006","journal-title":"Regul Pept"},{"issue":"2","key":"R49-31-20230327","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1398-9995.1997.tb00978.x","article-title":"Possible mechanisms of the concentration-dependent action of substance P to induce histamine release from rat peritoneal mast cells and the effect of extracellular calcium on mast-cell activation.","volume":"52","author":"Amano","year":"1997","journal-title":"Allergy"},{"issue":"1","key":"R50-31-20230327","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0143-4179(93)90035-9","article-title":"C-terminal substance P fragments elicit histamine release from a murine mast cell line.","volume":"24","author":"Krumins","year":"1993","journal-title":"Neuropeptides"},{"issue":"1-3","key":"R51-31-20230327","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000236946","article-title":"Substance-P-induced histamine release from human nasal mucosa in vitro.","volume":"107","author":"Schierhorn","year":"1995","journal-title":"Int Arch Allergy Immunol"},{"issue":"18","key":"R52-31-20230327","doi-asserted-by":"crossref","first-page":"7581","DOI":"10.1523\/JNEUROSCI.18-18-07581.1998","article-title":"Inflammatory mediators sensitize acutely axotomized nerve fibers to mechanical stimulation in the rat.","volume":"18","author":"Michaelis","year":"1998","journal-title":"J Neurosci"},{"issue":"3","key":"R53-31-20230327","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0363-5023(90)90070-8","article-title":"Idiopathic carpal tunnel syndrome: histologic study of flexor tendon synovium.","volume":"15","author":"Schuind","year":"1990","journal-title":"J Hand Surg Am"},{"issue":"1","key":"R54-31-20230327","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0266-7681(94)90045-0","article-title":"Serial overnight recordings of intracarpal canal pressure in carpal tunnel syndrome patients with and without wrist splinting.","volume":"19","author":"Luchetti","year":"1994","journal-title":"J Hand Surg Br"},{"issue":"6","key":"R55-31-20230327","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jhsa.2006.03.004","article-title":"Segmental carpal canal pressure in patients with carpal tunnel syndrome.","volume":"31","author":"Ikeda","year":"2006","journal-title":"J Hand Surg Am"},{"issue":"4","key":"R56-31-20230327","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000057749","article-title":"Substance P induced preprotachykinin-a mRNA, neutral endopeptidase mRNA and substance P in cultured normal fibroblasts.","volume":"127","author":"Bae","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"issue":"3","key":"R57-31-20230327","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0304-3959(01)00410-9","article-title":"Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist.","volume":"95","author":"Cahill","year":"2002","journal-title":"Pain"},{"issue":"2","key":"R58-31-20230327","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0304-3959(94)90074-4","article-title":"Chronic pain and immunity: mononeuropathy alters immune responses in rats.","volume":"59","author":"Herzberg","year":"1994","journal-title":"Pain"},{"issue":"2","key":"R59-31-20230327","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0165-5728(96)00006-9","article-title":"Increased delayed type hypersensitivity in rats subjected to unilateral mononeuropathy is mediated by neurokinin-1 receptors.","volume":"65","author":"Herzberg","year":"1996","journal-title":"J Neuroimmunol"},{"issue":"7","key":"R60-31-20230327","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1097\/01.PRS.0000092065.60454.BE","article-title":"COX-2 up-regulation in idiopathic carpal tunnel syndrome.","volume":"112","author":"Talmor","year":"2003","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"R61-31-20230327","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/0269215507077294","article-title":"A systematic review of conservative treatment of carpal tunnel syndrome.","volume":"21","author":"Piazzini","year":"2007","journal-title":"Clin Rehabil"},{"issue":"7","key":"R62-31-20230327","first-page":"1186","article-title":"Treatments for carpal tunnel syndrome: who does what, whenand why?","volume":"53","author":"Taylor-Gjevre","year":"2007","journal-title":"Can Fam Physician"},{"issue":"6","key":"R63-31-20230327","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/jm9607010","article-title":"Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2\/COX-1 selectivity.","volume":"40","author":"Lazer","year":"1997","journal-title":"J Med Chem"},{"issue":"6","key":"R64-31-20230327","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/sj.bjp.0706660","article-title":"Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells.","volume":"147","author":"Gallicchio","year":"2006","journal-title":"Br J Pharmacol"},{"issue":"6","key":"R65-31-20230327","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1152\/japplphysiol.01276.2005","article-title":"Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs.","volume":"100","author":"Bergren","year":"2006","journal-title":"J Appl Physiol"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/67\/6\/1655\/32588141\/00006123-201012000-00031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/00006123-201012000-00031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:42:31Z","timestamp":1786120951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006123-201012000-00031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1227\/neu.0b013e3181fa7032","relation":{},"ISSN":["0148-396X"],"issn-type":[{"value":"0148-396X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}