{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:37:08Z","timestamp":1794490628869,"version":"4.9.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1227\/neu.0b013e3182233e24","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T02:45:00Z","timestamp":1305168300000},"page":"1272-1280","source":"Crossref","is-referenced-by-count":147,"title":["Regression of Recurrent Malignant Gliomas With Convection-Enhanced Delivery of Topotecan"],"prefix":"10.1227","volume":"69","author":[{"given":"Jeffrey N.","family":"Bruce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Canoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin C.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S.","family":"Rosenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Sands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Surapaneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candix L.","family":"Yanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Bagiella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"DeLaPaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"4","key":"R1-22-20230327","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/00006123-199804000-00013","article-title":"Survival and functional status after resection of recurrent glioblastoma multiforme.","volume":"42","author":"Barker","year":"1998","journal-title":"Neurosurgery"},{"issue":"6","key":"R2-22-20230327","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1073\/pnas.91.6.2076","article-title":"Convection-enhanced delivery of macromolecules in the brain.","volume":"91","author":"Bobo","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"R3-22-20230327","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3171\/jns.1998.88.4.0734","article-title":"Distribution and stability of antisense phosphorothioate oligonucleotides in rodent brain following direct intraparenchymal controlled-rate infusion.","volume":"88","author":"Broaddus","year":"1998","journal-title":"J Neurosurg"},{"issue":"1-2","key":"R4-22-20230327","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0006-8993(99)02089-2","article-title":"Comparison of cytosine arabinoside delivery to rat brain by intravenous, intrathecal, intraventricular and intraparenchymal routes of administration.","volume":"856","author":"Groothuis","year":"2000","journal-title":"Brain Res"},{"issue":"6","key":"R5-22-20230327","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1097\/00006123-200012000-00026","article-title":"Tissue distribution and antitumor activity of topotecan delivered by intracerebral clysis in a rat glioma model.","volume":"47","author":"Kaiser","year":"2000","journal-title":"Neurosurgery"},{"issue":"1","key":"R7-22-20230327","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2217\/fon.09.135","article-title":"Future of convection-enhanced delivery in the treatment of brain tumors.","volume":"6","author":"Bidros","year":"2010","journal-title":"Future Oncol"},{"issue":"1","key":"R8-22-20230327","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/157488708783330521","article-title":"Clinical trials with intracerebral convection-enhanced delivery of targeted toxins in malignant glioma.","volume":"3","author":"Rainov","year":"2008","journal-title":"Rev Recent Clin Trials"},{"issue":"3","key":"R9-22-20230327","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3171\/jns.2004.100.3.0472","article-title":"Convection-enhanced delivery of paclitaxel for the treatment of recurrent malignant glioma: a phase III clinical study.","volume":"100","author":"Lidar","year":"2004","journal-title":"J Neurosurg"},{"issue":"8","key":"R10-22-20230327","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/neuonc\/nop054","article-title":"Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma.","volume":"12","author":"Kunwar","year":"2010","journal-title":"Neuro Oncol"},{"issue":"3","key":"R11-22-20230327","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/00006123-200003000-00031","article-title":"Intracerebral clysis in a rat glioma model.","volume":"46","author":"Bruce","year":"2000","journal-title":"Neurosurgery"},{"issue":"1","key":"R12-22-20230327","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1634\/theoncologist.3-1-1","article-title":"Topotecan: incorporating It Into the treatment of solid tumors.","volume":"3","author":"Burris","year":"1998","journal-title":"Oncologist"},{"issue":"2","key":"R13-22-20230327","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jso.2930530210","article-title":"Quantitative analysis of DNA topoisomerase I activity in human and rat glioma: characterization and mechanism of resistance to antitopoisomerase chemical, camptothecin-11.","volume":"53","author":"Matsumoto","year":"1993","journal-title":"J Surg Oncol"},{"issue":"5","key":"R14-22-20230327","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/(SICI)1097-0142(19990301)85:5<1160::AID-CNCR21>3.0.CO;2-F","article-title":"Topotecan treatment of adults with primary malignant glioma: the Brain Tumor Center at Duke.","volume":"85","author":"Friedman","year":"1999","journal-title":"Cancer"},{"issue":"1-2","key":"R15-22-20230327","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0378-4347(99)00078-X","article-title":"Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods.","volume":"727","author":"Rosing","year":"1999","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"5","key":"R16-22-20230327","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/00001199-200210000-00007","article-title":"Development and validation of a Web-based screening tool for monitoring cognitive status.","volume":"17","author":"Erlanger","year":"2002","journal-title":"J Head Trauma Rehabil"},{"issue":"6","key":"R17-22-20230327","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36), I: conceptual framework and item selection.","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"issue":"2","key":"R18-22-20230327","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/neuonc\/5.2.79","article-title":"A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma.","volume":"5","author":"Westphal","year":"2003","journal-title":"Neuro Oncol"},{"issue":"5","key":"R19-22-20230327","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1470-2045(08)70125-6","article-title":"Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas.","volume":"9","author":"Brandsma","year":"2008","journal-title":"Lancet Oncol"},{"issue":"3","key":"R20-22-20230327","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1212\/01.WNL.0000133398.11870.9A","article-title":"Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.","volume":"63","author":"de Wit","year":"2004","journal-title":"Neurology"},{"issue":"1","key":"R21-22-20230327","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3171\/jns.2003.98.1.0014","article-title":"Prognostic value of magnetic resonance imaging-guided stereotactic biopsy in the evaluation of recurrent malignant astrocytoma compared with a lesion due to radiation effect.","volume":"98","author":"McGirt","year":"2003","journal-title":"J Neurosurg"},{"issue":"5","key":"R22-22-20230327","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1017\/S0317167100008131","article-title":"Population-based study of pseudoprogression after chemoradiotherapy in GBM.","volume":"36","author":"Roldan","year":"2009","journal-title":"Can J Neurol Sci"},{"key":"R23-22-20230327","first-page":"105","article-title":"Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies.","volume":"88","author":"Kunwar","year":"2003","journal-title":"Acta Neurochir Suppl"},{"issue":"12","key":"R24-22-20230327","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/nm1297-1362","article-title":"Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors.","volume":"3","author":"Laske","year":"1997","journal-title":"Nat Med"},{"issue":"6","key":"R25-22-20230327","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1227\/01.NEU.0000159649.71890.30","article-title":"Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: initial experience in 51 patients.","volume":"56","author":"Patel","year":"2005","journal-title":"Neurosurgery"},{"issue":"9","key":"R26-22-20230327","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1007\/s00259-005-1819-7","article-title":"O-(2-18Ffluoroethyl)-L-tyrosine PET for monitoring the effects of convection-enhanced delivery of paclitaxel in patients with recurrent glioblastoma.","volume":"32","author":"Popperl","year":"2005","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"6","key":"R27-22-20230327","first-page":"2157","article-title":"Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma.","volume":"6","author":"Rand","year":"2000","journal-title":"Clin Cancer Res"},{"issue":"1","key":"R28-22-20230327","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1026290315809","article-title":"Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.","volume":"65","author":"Sampson","year":"2003","journal-title":"J Neurooncol"},{"issue":"4","key":"R29-22-20230327","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/ana.10688","article-title":"Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma.","volume":"54","author":"Voges","year":"2003","journal-title":"Ann Neurol"},{"key":"R30-22-20230327","first-page":"93","article-title":"Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma.","volume":"88","author":"Weber","year":"2003","journal-title":"Acta Neurochir Suppl"},{"issue":"5","key":"R31-22-20230327","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.apradiso.2004.05.071","article-title":"Boronated epidermal growth factor as a delivery agent for neutron capture therapy of EGF receptor positive gliomas.","volume":"61","author":"Yang","year":"2004","journal-title":"Appl Radiat Isot"},{"issue":"16","key":"R32-22-20230327","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1200\/JCO.2006.10.0677","article-title":"Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm.","volume":"25","author":"Gerstner","year":"2007","journal-title":"J Clin Oncol"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/69\/6\/1272\/32590864\/neurosurgery-69-6-1272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/00006123-201112000-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:46:56Z","timestamp":1786121216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006123-201112000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1227\/neu.0b013e3182233e24","relation":{},"ISSN":["0148-396X"],"issn-type":[{"value":"0148-396X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}