{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:35:03Z","timestamp":1788197703049,"version":"build-2803163510"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Because only a limited proportion of vestibular schwannomas display growth after diagnosis, an increasing number of patients are managed conservatively. Tumor growth during \u201cwait and scan\u201d may, however, necessitate surgery. In these cases, increased tumor size is likely to increase the risk of impaired facial nerve function after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To compare facial nerve function in patients operated on soon after diagnosis with patients allocated to conservative management and the subgroup of these who later had surgery because of tumor growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A total of 1378 consecutive patients diagnosed with a vestibular schwannoma 20 mm extrameatal or smaller were included; 419 patients were operated on soon after diagnosis, and 959 patients were initially managed conservatively. In the latter group, 161 patients were subsequently operated on owing to tumor growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>All conservatively managed patients had normal facial nerve function at the end of observation. Good facial nerve outcome was found in 87% of patients operated on at diagnosis and in 84% of patients operated on after established tumor growth. For the subgroup of small extrameatal tumors, this difference was significant. When all patients allocated primarily to conservative management were pooled, good facial function was found in 97%, which was significantly better than the result for primary operation (87%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Overall, conservative management of small to medium-sized vestibular schwannomas is the best option in terms of preservation of facial nerve function. Tumor growth during observation is found in only a minor proportion of the patients, and in these cases, surgery or irradiation should be performed immediately.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1227\/neu.0b013e31822f7d5f","type":"journal-article","created":{"date-parts":[[2011,7,30]],"date-time":"2011-07-30T13:03:43Z","timestamp":1312031023000},"page":"278-282","source":"Crossref","is-referenced-by-count":18,"title":["Facial Nerve Function After Vestibular Schwannoma Surgery Following Failed Conservative Management"],"prefix":"10.1227","volume":"70","author":[{"given":"Mikkel","family":"Kaltoft","sequence":"first","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Copenhagen University Hospital Gentofte, Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven-Eric","family":"Stangerup","sequence":"first","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Copenhagen University Hospital Gentofte, Copenhagen, Copenhagen, Denmark"},{"name":"Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Caye-Thomasen","sequence":"first","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Copenhagen University Hospital Gentofte, Copenhagen, Copenhagen, Denmark"},{"name":"Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2011,7,27]]},"reference":[{"issue":"5","key":"2020022604305791000_R1-13","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1227\/NEU.0b013e3181f22660","article-title":"True incidence of vestibular schwannoma?","volume":"67","author":"Stangerup","year":"2010","journal-title":"Neurosurgery"},{"issue":"4","key":"2020022604305791000_R2-13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/00129492-200606000-00018","article-title":"The natural history of vestibular schwannoma","volume":"27","author":"Stangerup","year":"2006","journal-title":"Otol Neurotol"},{"issue":"7","key":"2020022604305791000_R3-13","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/01.MLG.0000217528.37106.2D","article-title":"Sublocalization and volumetric growth pattern of intracanalicular vestibular schwannomas","volume":"116","author":"Caye-Thomasen","year":"2006","journal-title":"Laryngoscope"},{"issue":"6","key":"2020022604305791000_R4-13","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/MLG.0b013e31816a8955","article-title":"Conservative management of vestibular schwannomas: an effective strategy","volume":"118","author":"Ferri","year":"2008","journal-title":"Laryngoscope"},{"issue":"3","key":"2020022604305791000_R5-13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1749-4486.2008.01715.x","article-title":"Conservative versus primary surgical treatment of acoustic neuromas: a comparison of rates of facial nerve and hearing preservation","volume":"33","author":"Martin","year":"2008","journal-title":"Clin Otolaryngol"},{"issue":"3","key":"2020022604305791000_R6-13","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/00005537-200503000-00011","article-title":"Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm","volume":"115","author":"Smouha","year":"2005","journal-title":"Laryngoscope"},{"issue":"5","key":"2020022604305791000_R7-13","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.otohns.2006.10.009","article-title":"Facial nerve function after translabyrinthine vestibular schwannoma surgery","volume":"136","author":"Brackmann","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"10","key":"2020022604305791000_R8-13","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/00016480510038013","article-title":"Conservative management versus surgery for small vestibular schwannomas","volume":"125","author":"Bozorg Grayeli","year":"2005","journal-title":"Acta Otolaryngol"},{"issue":"4","key":"2020022604305791000_R9-13","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1097\/00129492-200307000-00019","article-title":"New and modified reporting systems from the consensus meeting on systems for reporting results in vestibular schwannoma","volume":"24","author":"Kanzaki","year":"2003","journal-title":"Otol Neurotol"},{"issue":"2","key":"2020022604305791000_R10-13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/019459988509300202","article-title":"Facial nerve grading system","volume":"93","author":"House","year":"1985","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"2020022604305791000_R11-13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/MAO.0b013e31809ed94f","article-title":"Evaluation of facial function with a questionnaire: reliability and validity","volume":"28","author":"Cullen","year":"2007","journal-title":"Otol Neurotol"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/70\/2\/278\/32585952\/neurosurgery-70-2-278.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/70\/2\/278\/32585952\/neurosurgery-70-2-278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T12:33:05Z","timestamp":1668083585000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.lww.com\/10.1227\/NEU.0b013e31822f7d5f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,27]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,7,27]]},"published-print":{"date-parts":[[2012,2,1]]}},"URL":"https:\/\/doi.org\/10.1227\/neu.0b013e31822f7d5f","relation":{},"ISSN":["1524-4040","0148-396X"],"issn-type":[{"value":"1524-4040","type":"electronic"},{"value":"0148-396X","type":"print"}],"subject":[],"published-other":{"date-parts":[[2012,2]]},"published":{"date-parts":[[2011,7,27]]}}}