{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:56:15Z","timestamp":1792515375846,"version":"4.5.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Gamma Knife radiosurgery (GKRS) has been reported to be an effective modality to treat trigeminal neuralgia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To determine predictive factors for the successful treatment of trigeminal neuralgia with GKRS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Between 1999 and 2008, 777 GKRS procedures for patients with trigeminal neuralgia were performed at our institution. Evaluable follow-up data were obtained for 448 patients. Median follow-up time was 20.9 months (range, 3\u201386 months). The mean maximum prescribed dose was 88 Gy (range, 80\u201397 Gy). Dosimetric variables recorded included dorsal root entry zone dose, pons maximum dose, dose to the petrous dural ridge, and cisternal nerve length.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>By 3 months after GKRS, 86% of patients achieved Barrow Neurologic Institute I to III pain scores, with 43% of patients achieving a Barrow Neurologic Institute I pain score. Twenty-six percent of patients reported posttreatment facial numbness; 28% of patients reported a post-GKRS procedure for relapsed pain, and median time to next procedure was 4.4 years. Multivariate analysis revealed that the development of postsurgical numbness (odds ratio [OR], 2.76; P = .006) was the dominant factor predictive of efficacy. Longer cisternal nerve length (OR, 0.85; P = .005), prior radiofrequency ablation (OR, 0.35; P = .028), and diabetes mellitus (OR, 0.38; P = .013) predicted decreased efficacy. The mean dose delivered to the dorsal root entry zone dose in patients who developed facial numbness (57.6 Gy) was more than the mean dose (47.3 Gy) given to patients who did not develop numbness (P = .02).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The development of post-GKRS facial numbness is a dominant factor that predicts for efficacy of GKRS. History of diabetes mellitus or previous radio-frequency ablation may portend worsened outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1227\/neu.0b013e3182320d36","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T18:04:16Z","timestamp":1317751456000},"page":"566-573","source":"Crossref","is-referenced-by-count":85,"title":["Predictive Variables for the Successful Treatment of Trigeminal Neuralgia With Gamma Knife Radiosurgery"],"prefix":"10.1227","volume":"70","author":[{"given":"Kopriva","family":"Marshall","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Wake Forest University Health Sciences, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Wake Forest University Health Sciences, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"McCoy","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Aubuchon","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Wake Forest University Health Sciences, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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