{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:25:30Z","timestamp":1788038730862,"version":"build-2784847793"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1227\/neu.0b013e318243fc59","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T13:57:31Z","timestamp":1322834251000},"page":"1220-1231","source":"Crossref","is-referenced-by-count":47,"title":["The Relationship Between Intracranial Pressure and Brain Oxygenation in Children With Severe Traumatic Brain Injury"],"prefix":"10.1227","volume":"70","author":[{"given":"Ursula K.","family":"Rohlwink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Zwane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Graham Fieggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Argent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"le Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A.","family":"Figaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"9233","key":"R1-19-20230327","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0140-6736(00)02689-1","article-title":"Traumatic brain injury.","volume":"356","author":"Ghajar","year":"2000","journal-title":"Lancet"},{"issue":"8","key":"R2-19-20230327","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S1474-4422(08)70164-9","article-title":"Moderate and severe traumatic brain injury in adults.","volume":"7","author":"Maas","year":"2008","journal-title":"Lancet Neurol"},{"issue":"9","key":"R3-19-20230327","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1097\/00003246-200209000-00029","article-title":"Outcome after traumatic brain injury improved by an organized secondary insult program and standardized neurointensive care.","volume":"30","author":"Elf","year":"2002","journal-title":"Crit Care Med"},{"issue":"3","key":"R5-19-20230327","first-page":"366","article-title":"Secondary brain insults after head injury: clinical perspectives.","volume":"3","author":"Chesnut","year":"1995","journal-title":"New Horiz"},{"issue":"2","key":"R7-19-20230327","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/msj.20106","article-title":"Severe traumatic brain injury: maximizing outcomes.","volume":"76","author":"Tang","year":"2009","journal-title":"Mt Sinai J Med"},{"issue":"3","key":"R8-19-20230327","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1136\/jnnp.52.3.346","article-title":". Ischaemic brain damage is still common in fatal non-missile head injury.","volume":"52","author":"Graham","year":"1989","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"R9-19-20230327","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.3171\/foc.2003.14.4.2","article-title":"Intracranial hypertension and cerebral ischemia after severe traumatic brain injury.","volume":"14","author":"Hlatky","year":"2003","journal-title":"Neurosurg Focus"},{"issue":"6","key":"R11-19-20230327","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1097\/CCM.0b013e3181a009f8","article-title":". Brain tissue oxygen and outcome after severe traumatic brain injury: a systematic review.","volume":"37","author":"Maloney-Wilensky","year":"2009","journal-title":"Crit Care Med"},{"issue":"10","key":"R12-19-20230327","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00381-009-0822-x","article-title":". Brain tissue oxygen tension monitoring in pediatric severe traumatic brain injury. Part 1: relationship with outcome.","volume":"25","author":"Figaji","year":"2009","journal-title":"Childs Nerv Syst"},{"issue":"9","key":"R13-19-20230327","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1097\/00003246-199809000-00029","article-title":"Relationship of brain tissue PO2 to outcome after severe head injury.","volume":"26","author":"Valadka","year":"1998","journal-title":"Crit Care Med"},{"issue":"suppl 1","key":"R14-19-20230327","first-page":"S65","article-title":"Congress of Neurological Surgeons, et al.. Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds.","volume":"24","year":"2007","journal-title":"J Neurotrauma"},{"issue":"6","key":"R16-19-20230327","first-page":"1401","article-title":"Pediatric traumatic brain injury: the utility of beta-natriuretic peptide.","volume":"68","author":"Chang","year":"2010","journal-title":"J Trauma"},{"issue":"4","key":"R17-19-20230327","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3171\/jns.2006.105.4.568","article-title":". Conventional neurocritical care and cerebral oxygenation after traumatic brain injury.","volume":"105","author":"Stiefel","year":"2006","journal-title":"J Neurosurg"},{"issue":"5","key":"R19-19-20230327","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3171\/JNS\/2008\/108\/5\/0943","article-title":"Cerebral oxygenation, vascular reactivity, and neurochemistry following decompressive craniectomy for severe traumatic brain injury.","volume":"108","author":"Ho","year":"2008","journal-title":"J Neurosurg"},{"key":"R20-19-20230327","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-211-85578-2_15","article-title":"Intracranial pressure and cerebral oxygenation changes after decompressive craniectomy in children with severe traumatic brain injury.","volume":"102","author":"Figaji","year":"2008","journal-title":"Acta Neurochir Suppl"},{"issue":"3","key":"R24-19-20230327","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ccc.2007.06.002","article-title":"Multimodality monitoring in neurocritical care.","volume":"23","author":"Wartenberg","year":"2007","journal-title":"Crit Care Clin"},{"issue":"4","key":"R25-19-20230327","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00381-009-1037-x","article-title":"The physiology behind direct brain oxygen monitors and practical aspects of their use.","volume":"26","author":"Maloney-Wilensky","year":"2010","journal-title":"Childs Nerv Syst"},{"issue":"4","key":"R26-19-20230327","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/clinchem\/39.4.561","article-title":"Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.","volume":"39","author":"Zweig","year":"1993","journal-title":"Clin Chem"},{"issue":"3","key":"R27-19-20230327","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3171\/jns.2001.94.3.0412","article-title":"Determination of threshold levels of cerebral perfusion pressure and intracranial pressure in severe head injury by using receiver-operating characteristic curves: an observational study in 291 patients.","volume":"94","author":"Chambers","year":"2001","journal-title":"J Neurosurg"},{"issue":"2","key":"R28-19-20230327","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/jnnp.2005.072215","article-title":". Critical thresholds of intracranial pressure and cerebral perfusion pressure related to age in paediatric head injury.","volume":"77","author":"Chambers","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"R29-19-20230327","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/CCM.0b013e318192fbd7","article-title":". Physiologic and functional outcome correlates of brain tissue hypoxia in traumatic brain injury.","volume":"37","author":"Chang","year":"2009","journal-title":"Crit Care Med"},{"issue":"1","key":"R30-19-20230327","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00006123-199601000-00007","article-title":"Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury.","volume":"38","author":"van Santbrink","year":"1996","journal-title":"Neurosurgery"},{"issue":"4","key":"R31-19-20230327","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3171\/2009.4.JNS081150","article-title":"Brain tissue oxygen monitoring in traumatic brain injury and major trauma: outcome analysis of a brain tissue oxygen-directed therapy.","volume":"111","author":"Narotam","year":"2009","journal-title":"J Neurosurg"},{"issue":"3","key":"R32-19-20230327","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3171\/2010.1.JNS09506","article-title":". Brain tissue oxygen-directed management and outcome in patients with severe traumatic brain injury.","volume":"113","author":"Spiotta","year":"2010","journal-title":"J Neurosurg"},{"issue":"3","key":"R33-19-20230327","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jpedsurg.2005.11.069","article-title":"Cerebral oxygenation in major pediatric trauma: its relevance to trauma severity and outcome.","volume":"41","author":"Narotam","year":"2006","journal-title":"J Pediatr Surg"},{"issue":"2","key":"R34-19-20230327","first-page":"110","article-title":"Microdialysis: is it ready for prime time Curr Opin Crit Care.","volume":"15","author":"Goodman","year":"2009","journal-title":""},{"issue":"2","key":"R35-19-20230327","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00381-009-1031-3","article-title":"Intracerebral microdialysis in children.","volume":"26","author":"Charalambides","year":"2010","journal-title":"Childs Nerv Syst"},{"issue":"2","key":"R36-19-20230327","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3171\/jns.2000.93.2.0265","article-title":". Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe.","volume":"93","author":"Vajkoczy","year":"2000","journal-title":"J Neurosurg"},{"issue":"9","key":"R38-19-20230327","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1097\/00003246-200009000-00024","article-title":"CO2 reactivity and brain oxygen pressure monitoring in severe head injury.","volume":"28","author":"Carmona Suazo","year":"2000","journal-title":"Crit Care Med"},{"issue":"3","key":"R39-19-20230327","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00008506-200407000-00005","article-title":"Individual value of brain tissue oxygen pressure, microvascular oxygen saturation, cytochrome redox level, and energy metabolites in detecting critically reduced cerebral energy state during acute changes in global cerebral perfusion.","volume":"16","author":"Scheufler","year":"2004","journal-title":"J Neurosurg Anesthesiol"},{"issue":"6","key":"R40-19-20230327","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1097\/01.CCM.0000127777.16609.08","article-title":". Diffusion limited oxygen delivery following head injury.","volume":"32","author":"Menon","year":"2004","journal-title":"Crit Care Med"},{"issue":"6","key":"R41-19-20230327","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1097\/CCM.0b013e3181743d77","article-title":". Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury.","volume":"36","author":"Rosenthal","year":"2008","journal-title":"Crit Care Med"},{"issue":"7","key":"R42-19-20230327","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1089\/0897715041526195","article-title":"Patterns of energy substrates during ischemia measured in the brain by microdialysis.","volume":"21","author":"Hlatky","year":"2004","journal-title":"J Neurotrauma"},{"issue":"5","key":"R43-19-20230327","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1523\/JNEUROSCI.4105-07.2008","article-title":". Gamma oscillations and spontaneous network activity in the hippocampus are highly sensitive to decreases in pO2 and concomitant changes in mitochondrial redox state.","volume":"28","author":"Huchzermeyer","year":"2008","journal-title":"J Neurosci"},{"key":"R44-19-20230327","first-page":"299","article-title":"Brain tissue PO2: correlation with cerebral blood flow.","volume":"81","author":"Valadka","year":"2002","journal-title":"Acta Neurochir Suppl"},{"issue":"3","key":"R45-19-20230327","first-page":"549","article-title":". Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury.","volume":"88","author":"Gupta","year":"1999","journal-title":"Anesth Analg"},{"issue":"2","key":"R46-19-20230327","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/MCC.0b013e32808255dc","article-title":"Pediatric traumatic brain injury: not just little adults.","volume":"13","author":"Giza","year":"2007","journal-title":"Curr Opin Crit Care"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/70\/5\/1220\/32586459\/00006123-201205000-00019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/00006123-201205000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:55:25Z","timestamp":1786121725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006123-201205000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1227\/neu.0b013e318243fc59","relation":{},"ISSN":["0148-396X"],"issn-type":[{"value":"0148-396X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}