{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:33:17Z","timestamp":1765279997418,"version":"3.41.2"},"reference-count":20,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":1598,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"name":"ALF Grant","award":["ALFGBG-143521"],"award-info":[{"award-number":["ALFGBG-143521"]}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["Ref No: 130355"],"award-info":[{"award-number":["Ref No: 130355"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Biological compatibility, in terms of implantation of foreign mesh material in hernia surgery, still needs experimental investigation. Present study develops an experimental model using human peritoneum to study the integration between tissue and different mesh material. The ex vivo model using peritoneal tissue was studied with different mesh material, and integration was monitored over time using microscopy.<\/jats:p>\n               <jats:p>It could be demonstrated that the peritoneal model may be kept viable in culture for several weeks. Cell migration was seen after 7-10 days in culture and could be further monitored over several weeks. The use of a human artificial model environment enabling the investigation of tissue\/mesh integration has, to our knowledge, not been described previously.<\/jats:p>\n               <jats:p>This proof-of-concept model was developed, for the investigation of peritoneal biology and the integration between tissue and different mesh material. It has the potential to be useful in studies on other important biological mechanisms involving the peritoneum.<\/jats:p>","DOI":"10.1242\/bio.024992","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:20:10Z","timestamp":1501546810000},"source":"Crossref","is-referenced-by-count":2,"title":["An <i>ex vivo<\/i> model using human peritoneum to explore mesh-tissue integration"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3537-5497","authenticated-orcid":false,"given":"Peter","family":"Falk","sequence":"first","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska academy at University of Gothenburg, SE-416 85 G\u00f6teborg, Sweden"},{"name":"Hallands Hospital, SE-434 80 Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Ruiz-Jasbon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska academy at University of Gothenburg, SE-416 85 G\u00f6teborg, Sweden"},{"name":"Hallands Hospital, SE-434 80 Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Strig\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Gunnarsson","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Lois","family":"Ivarsson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska academy at University of Gothenburg, SE-416 85 G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2021042423510855100_BIO024992C1","doi-asserted-by":"publisher","first-page":"e265","DOI":"10.1016\/j.jss.2010.09.041","article-title":"Investigation of tumor-peritoneal interactions in the pathogenesis of peritoneal metastases using a novel ex vivo peritoneal model","volume":"164","author":"Cabourne","year":"2010","journal-title":"J. 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