{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T19:15:15Z","timestamp":1772738115397,"version":"3.50.1"},"reference-count":70,"publisher":"The Company of Biologists","issue":"11","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":1023,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"name":"Ram\u00f3n y Cajal program","award":["RYC-212-11410"],"award-info":[{"award-number":["RYC-212-11410"]}]},{"name":"Spanish Ministry of Economy, and the COST Action PROTEOSTASIS","award":["BM1307, BFU2012-38191 BFU2015-65685P"],"award-info":[{"award-number":["BM1307, BFU2012-38191 BFU2015-65685P"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The human A\u03b242 peptide is associated with Alzheimer's disease through its deleterious effects in neurons. Expressing the human peptide in adult Drosophila in a tissue- and time-controlled manner, we show that A\u03b242 is also toxic in non-neural cells, neurosecretory and epithelial cell types in particular. This form of toxicity includes the aberrant signaling by Wingless morphogen leading to the eventual activation of Caspase 3. Preventing Caspase 3 activation by means of p53 keeps epithelial cells from elimination but maintains the A\u03b242 toxicity yielding more severe deleterious effects to the organism. Metabolic profiling by nuclear magnetic resonance (NMR) of adult flies at selected ages post A\u03b242 expression onset reveals characteristic changes in metabolites as early markers of the pathological process. All morphological and most metabolic features of A\u03b242 toxicity can be suppressed by the joint overexpression of PI3K.<\/jats:p>","DOI":"10.1242\/bio.029991","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T09:30:10Z","timestamp":1510738210000},"page":"1664-1671","source":"Crossref","is-referenced-by-count":7,"title":["Amyloid \u03b242 peptide is toxic to non-neural cells in<i>Drosophila<\/i>yielding a characteristic metabolite profile and the effect can be suppressed by PI3K"],"prefix":"10.1242","volume":"6","author":[{"given":"Mercedes","family":"Arn\u00e9s","sequence":"first","affiliation":[{"name":"Dept. of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, Avda. Doctor Arce, 37, 28002 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Casas-Tint\u00f3","sequence":"additional","affiliation":[{"name":"Dept. of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, Avda. Doctor Arce, 37, 28002 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8413-9717","authenticated-orcid":false,"given":"Anders","family":"Malmendal","sequence":"additional","affiliation":[{"name":"Biochemistry and Structural Biology, Center for Molecular Protein Science, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0346-0489","authenticated-orcid":false,"given":"Alberto","family":"Ferr\u00fas","sequence":"additional","affiliation":[{"name":"Dept. of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, Avda. Doctor Arce, 37, 28002 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"2021042423341540400_BIO029991C1","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.cub.2010.04.039","article-title":"The leucokinin pathway and its neurons regulate meal size in Drosophila","volume":"20","author":"Al-Anzi","year":"2010","journal-title":"Curr. Biol."},{"key":"2021042423341540400_BIO029991C2","doi-asserted-by":"publisher","first-page":"19235","DOI":"10.1074\/jbc.R116.746032","article-title":"A Greek tragedy: the growing complexity of Alzheimer amyloid precursor protein proteolysis","volume":"291","author":"Andrew","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2021042423341540400_BIO029991C3","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1080\/030097498442208","article-title":"Sporadic inclusion-body myositis and its similarities to Alzheimer disease brain: recent approaches to diagnosis and pathogenesis, and relation to aging","volume":"27","author":"Askanas","year":"1998","journal-title":"Scand. J. Rheumatol."},{"key":"2021042423341540400_BIO029991C4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3233\/JAD-2005-8107","article-title":"Cause of death in demented and non-demented elderly inpatients; an autopsy study of 308 cases","volume":"8","author":"Attems","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"2021042423341540400_BIO029991C5","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1111\/j.1582-4934.2008.00385.x","article-title":"Alzheimer's disease beyond the genomic era: nuclear magnetic resonance (NMR) spectroscopy-based metabolomics","volume":"12","author":"Barba","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"2021042423341540400_BIO029991C6","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1079\/BJN20061761","article-title":"NMR-based metabonomic studies reveal changes in the biochemical profile of plasma and urine from pigs fed high-fibre rye bread","volume":"95","author":"Bertram","year":"2006","journal-title":"Br. J. Nutr."},{"key":"2021042423341540400_BIO029991C7","doi-asserted-by":"publisher","first-page":"e17578","DOI":"10.7554\/eLife.17578","article-title":"The amyloid-beta forming tripeptide cleavage mechanism of gamma-secretase","volume":"5","author":"Bolduc","year":"2016","journal-title":"Elife"},{"key":"2021042423341540400_BIO029991C8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"2021042423341540400_BIO029991C9","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1468-1331.2008.02503.x","article-title":"Cause of death in patients with dementia disorders","volume":"16","author":"Brunnstr\u00f6m","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"2021042423341540400_BIO029991C10","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1073\/pnas.90.5.2092","article-title":"Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells","volume":"90","author":"Busciglio","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042423341540400_BIO029991C11","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/BF00353901","article-title":"Segmental peptidergic innervation of abdominal targets in larval and adult dipteran insects revealed with an antiserum against leucokinin I","volume":"269","author":"Cantera","year":"1992","journal-title":"Cell Tissue Res."},{"key":"2021042423341540400_BIO029991C12","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/0896-6273(88)90131-6","article-title":"Immunocytochemical localization of the precursor protein for beta-amyloid in the rat central nervous system","volume":"1","author":"Card","year":"1988","journal-title":"Neuron"},{"key":"2021042423341540400_BIO029991C13","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1093\/hmg\/ddr100","article-title":"The ER stress factor XBP1s prevents amyloid-beta neurotoxicity","volume":"20","author":"Casas-Tint\u00f3","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"2021042423341540400_BIO029991C14","doi-asserted-by":"publisher","first-page":"170039","DOI":"10.1098\/rsos.170039","article-title":"Drosophila enhancer-Gal4 lines show ectopic expression during development","volume":"4","author":"Casas-Tint\u00f3","year":"2017","journal-title":"R. Soc. Open Sci."},{"key":"2021042423341540400_BIO029991C15","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1093\/hmg\/11.23.2895","article-title":"Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila","volume":"11","author":"Chan","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2021042423341540400_BIO029991C16","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/BF00331367","article-title":"Leucokinin and diuretic hormone immunoreactivity of neurons in the tobacco hornworm, Manduca sexta, and co-localization of this immunoreactivity in lateral neurosecretory cells of abdominal ganglia","volume":"278","author":"Chen","year":"1994","journal-title":"Cell Tissue Res."},{"key":"2021042423341540400_BIO029991C17","doi-asserted-by":"publisher","first-page":"e78066","DOI":"10.1371\/journal.pone.0078066","article-title":"Mapping an atlas of tissue-specific Drosophila melanogaster metabolomes by high resolution mass spectrometry","volume":"8","author":"Chintapalli","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042423341540400_BIO029991C18","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1523\/JNEUROSCI.4477-10.2011","article-title":"Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons","volume":"31","author":"Cuesto","year":"2011","journal-title":"J. Neurosci."},{"key":"2021042423341540400_BIO029991C19","doi-asserted-by":"publisher","first-page":"e0118475","DOI":"10.1371\/journal.pone.0118475","article-title":"GSK3beta inhibition promotes synaptogenesis in Drosophila and mammalian neurons","volume":"10","author":"Cuesto","year":"2015","journal-title":"PLoS ONE"},{"key":"2021042423341540400_BIO029991C20","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nbt0208-162","article-title":"Metabolite identification via the Madison Metabolomics Consortium Database","volume":"26","author":"Cui","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"2021042423341540400_BIO029991C21","doi-asserted-by":"publisher","first-page":"e31501","DOI":"10.1371\/journal.pone.0031501","article-title":"Metabolite profiling of Alzheimer's disease cerebrospinal fluid","volume":"7","author":"Czech","year":"2012","journal-title":"PLoS ONE"},{"key":"2021042423341540400_BIO029991C22","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00441-009-0890-y","article-title":"Detailed analysis of leucokinin-expressing neurons and their candidate functions in the Drosophila nervous system","volume":"339","author":"de Haro","year":"2010","journal-title":"Cell Tissue Res."},{"key":"2021042423341540400_BIO029991C23","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer's disease","volume":"164","author":"De Strooper","year":"2016","journal-title":"Cell"},{"key":"2021042423341540400_BIO029991C24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4161\/org.24107","article-title":"Shaping up for action: the path to physiological maturation in the renal tubules of Drosophila","volume":"9","author":"Denholm","year":"2013","journal-title":"Organogenesis"},{"key":"2021042423341540400_BIO029991C25","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nmeth.1356","article-title":"G-TRACE: rapid Gal4-based cell lineage analysis in Drosophila","volume":"6","author":"Evans","year":"2009","journal-title":"Nat. Methods"},{"key":"2021042423341540400_BIO029991C26","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1534\/genetics.107.085555","article-title":"Overexpression screen in Drosophila identifies neuronal roles of GSK-3 beta\/shaggy as a regulator of AP-1-dependent developmental plasticity","volume":"180","author":"Franciscovich","year":"2008","journal-title":"Genetics"},{"key":"2021042423341540400_BIO029991C27","doi-asserted-by":"publisher","first-page":"3751","DOI":"10.1074\/jbc.M116.754101","article-title":"Zinc and copper differentially modulate amyloid precursor protein processing by gamma-secretase and amyloid-beta peptide production","volume":"292","author":"Gerber","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2021042423341540400_BIO029991C28","doi-asserted-by":"publisher","first-page":"962","DOI":"10.15252\/embr.201643519","article-title":"Posttranslational modification impact on the mechanism by which amyloid-beta induces synaptic dysfunction","volume":"18","author":"Grochowska","year":"2017","journal-title":"EMBO Rep."},{"key":"2021042423341540400_BIO029991C29","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1242\/dev.120.8.2121","article-title":"Expression of baculovirus P35 prevents cell death in Drosophila","volume":"120","author":"Hay","year":"1994","journal-title":"Development"},{"key":"2021042423341540400_BIO029991C30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/jmcb\/mjt051","article-title":"Wnt signaling in the nervous system and in Alzheimer's disease","volume":"6","author":"Inestrosa","year":"2014","journal-title":"J. Mol. Cell Biol."},{"key":"2021042423341540400_BIO029991C70","doi-asserted-by":"publisher","first-page":"e50245","DOI":"10.3791\/50245","article-title":"Purification of transcripts and metabolites from Drosophila heads","author":"Jensen","year":"2013","journal-title":"J. Vis. Exp."},{"key":"2021042423341540400_BIO029991C31","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/S0896-6273(03)00124-7","article-title":"APP processing and synaptic function","volume":"37","author":"Kamenetz","year":"2003","journal-title":"Neuron"},{"key":"2021042423341540400_BIO029991C32","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1104\/pp.104.040808","article-title":"beta-Amylase induction and the protective role of maltose during temperature shock","volume":"135","author":"Kaplan","year":"2004","journal-title":"Plant Physiol."},{"key":"2021042423341540400_BIO029991C33","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0012-1606(03)00215-X","article-title":"Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neurites","volume":"260","author":"Landgraf","year":"2003","journal-title":"Dev. Biol."},{"key":"2021042423341540400_BIO029991C34","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1242\/dev.121.12.4303","article-title":"Segmental patterning of heart precursors in Drosophila","volume":"121","author":"Lawrence","year":"1995","journal-title":"Development"},{"key":"2021042423341540400_BIO029991C35","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.nbd.2015.10.019","article-title":"Soluble Abeta oligomers impair hippocampal LTP by disrupting glutamatergic\/GABAergic balance","volume":"85","author":"Lei","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"2021042423341540400_BIO029991C36","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/0896-6273(94)90022-1","article-title":"Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance","volume":"13","author":"Lin","year":"1994","journal-title":"Neuron"},{"key":"2021042423341540400_BIO029991C37","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.peptides.2010.07.002","article-title":"Blockade of the release of the neuropeptide leucokinin to determine its possible functions in fly behavior: chemoreception assays","volume":"32","author":"L\u00f3pez-Arias","year":"2011","journal-title":"Peptides"},{"key":"2021042423341540400_BIO029991C38","doi-asserted-by":"publisher","first-page":"13888","DOI":"10.1038\/srep13888","article-title":"Comprehensive urinary metabolomic profiling and identification of potential noninvasive marker for idiopathic Parkinson's disease","volume":"5","author":"Luan","year":"2015","journal-title":"Sci. Rep."},{"key":"2021042423341540400_BIO029991C39","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3389\/fnmol.2016.00161","article-title":"Novel insights into the physiological function of the APP (gene) family and its proteolytic fragments in synaptic plasticity","volume":"9","author":"Ludewig","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"2021042423341540400_BIO029991C40","doi-asserted-by":"publisher","first-page":"R205","DOI":"10.1152\/ajpregu.00867.2005","article-title":"Metabolomic profiling of heat stress: hardening and recovery of homeostasis in Drosophila","volume":"291","author":"Malmendal","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042423341540400_BIO029991C41","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s00114-013-1040-7","article-title":"Metabolomic analysis of the selection response of Drosophila melanogaster to environmental stress: are there links to gene expression and phenotypic traits?","volume":"100","author":"Malmendal","year":"2013","journal-title":"Naturwissenschaften"},{"key":"2021042423341540400_BIO029991C42","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0301-0082(00)00003-4","article-title":"Calcium channels and the release of large dense core vesicles from neuroendocrine cells: spatial organization and functional coupling","volume":"62","author":"Mansvelder","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"2021042423341540400_BIO029991C43","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neurobiolaging.2016.11.007","article-title":"What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease","volume":"51","author":"Mapstone","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"2021042423341540400_BIO029991C44","doi-asserted-by":"publisher","first-page":"10199","DOI":"10.1523\/JNEUROSCI.1223-06.2006","article-title":"Age-independent synaptogenesis by phosphoinositide 3 kinase","volume":"26","author":"Martin-Pena","year":"2006","journal-title":"J. Neurosci."},{"key":"2021042423341540400_BIO029991C45","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1126\/science.1089035","article-title":"Spatiotemporal rescue of memory dysfunction in Drosophila","volume":"302","author":"McGuire","year":"2003","journal-title":"Science"},{"key":"2021042423341540400_BIO029991C46","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1469-7793.2001.t01-1-00115.x","article-title":"Fast synaptic transmission mediated by P2X receptors in CA3 pyramidal cells of rat hippocampal slice cultures","volume":"535","author":"Mori","year":"2001","journal-title":"J. Physiol."},{"key":"2021042423341540400_BIO029991C47","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/367080a0","article-title":"dishevelled and armadillo act in the wingless signalling pathway in Drosophila","volume":"367","author":"Noordermeer","year":"1994","journal-title":"Nature"},{"key":"2021042423341540400_BIO029991C48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neurobiolaging.2016.01.009","article-title":"Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity","volume":"41","author":"Ott","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"2021042423341540400_BIO029991C49","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/j.jinsphys.2007.06.012","article-title":"Metabolomic profiling of rapid cold hardening and cold shock in Drosophila melanogaster","volume":"53","author":"Overgaard","year":"2007","journal-title":"J. Insect Physiol."},{"key":"2021042423341540400_BIO029991C50","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.neuron.2009.08.006","article-title":"The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons","volume":"63","author":"Parrish","year":"2009","journal-title":"Neuron"},{"key":"2021042423341540400_BIO029991C51","doi-asserted-by":"publisher","first-page":"15572","DOI":"10.1021\/jp060789l","article-title":"Interaction of the sugars trehalose, maltose and glucose with a phospholipid bilayer: a comparative molecular dynamics study","volume":"110","author":"Pereira","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"2021042423341540400_BIO029991C52","doi-asserted-by":"publisher","first-page":"17664","DOI":"10.1073\/pnas.0508966102","article-title":"Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila","volume":"102","author":"Perez-Garijo","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042423341540400_BIO029991C53","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1242\/dev.034017","article-title":"The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc","volume":"136","author":"Perez-Garijo","year":"2009","journal-title":"Development"},{"key":"2021042423341540400_BIO029991C54","first-page":"523","article-title":"Anti-inflammatory and antisecretory potential of histidine in Salmonella-challenged mouse small intestine","volume":"78","author":"Peterson","year":"1998","journal-title":"Lab. Invest."},{"key":"2021042423341540400_BIO029991C55","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.devcel.2010.09.004","article-title":"Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition","volume":"19","author":"Portela","year":"2010","journal-title":"Dev. Cell"},{"key":"2021042423341540400_BIO029991C56","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1021\/acs.jproteome.6b00829","article-title":"Mass-spectrometry-based method to quantify in parallel tau and amyloid beta 1-42 in CSF for the diagnosis of Alzheimer's disease","volume":"16","author":"Pottiez","year":"2017","journal-title":"J. Proteome Res."},{"key":"2021042423341540400_BIO029991C57","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1159\/000022031","article-title":"Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients","volume":"44","author":"Redjems-Bennani","year":"1998","journal-title":"Gerontology"},{"key":"2021042423341540400_BIO029991C58","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/0092-8674(90)90451-J","article-title":"Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless","volume":"63","author":"Riggleman","year":"1990","journal-title":"Cell"},{"key":"2021042423341540400_BIO029991C59","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.neuint.2010.04.001","article-title":"A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease","volume":"56","author":"Salek","year":"2010","journal-title":"Neurochem. Int."},{"key":"2021042423341540400_BIO029991C60","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jmr.2009.11.012","article-title":"icoshift: a versatile tool for the rapid alignment of 1D NMR spectra","volume":"202","author":"Savorani","year":"2010","journal-title":"J. Magn. Reson."},{"key":"2021042423341540400_BIO029991C61","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fnmol.2016.00149","article-title":"The emerging role of tetraspanins in the proteolytic processing of the amyloid precursor protein","volume":"9","author":"Seipold","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"2021042423341540400_BIO029991C62","doi-asserted-by":"publisher","first-page":"e1001087","DOI":"10.1371\/journal.pgen.1001087","article-title":"Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease","volume":"6","author":"Sofola","year":"2010","journal-title":"PLoS Genet."},{"key":"2021042423341540400_BIO029991C63","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2217\/bmm-2016-0276","article-title":"Selecting Abeta isoforms for an Alzheimer's disease cerebrospinal fluid biomarker panel","volume":"11","author":"Somers","year":"2017","journal-title":"Biomark Med."},{"key":"2021042423341540400_BIO029991C64","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1242\/jeb.202.24.3667","article-title":"Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster","volume":"202","author":"Terhzaz","year":"1999","journal-title":"J. Exp. Biol."},{"key":"2021042423341540400_BIO029991C65","doi-asserted-by":"publisher","first-page":"e63644","DOI":"10.1371\/journal.pone.0063644","article-title":"Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics","volume":"8","author":"Trushina","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042423341540400_BIO029991C66","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/cem.775","article-title":"O2-PLS, a two-block (X\u2013Y) latent variable regression (LVR) method with an integral OSC filter","volume":"17","author":"Trygg","year":"2003","journal-title":"J. Chemometrics"},{"key":"2021042423341540400_BIO029991C67","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.devcel.2011.06.021","article-title":"Steep differences in wingless signaling trigger Myc-independent competitive cell interactions","volume":"21","author":"Vincent","year":"2011","journal-title":"Dev. Cell"},{"key":"2021042423341540400_BIO029991C68","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1042\/bst0300552","article-title":"Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition","volume":"30","author":"Walsh","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"2021042423341540400_BIO029991C69","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/mp.2016.134","article-title":"Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism","volume":"21","author":"Westmark","year":"2016","journal-title":"Mol. Psychiatry"}],"container-title":["Biology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/bio.029991","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.logists.com\/bio\/bio\/article-pdf\/6\/11\/1664\/1830882\/bio029991.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.logists.com\/bio\/bio\/article-pdf\/6\/11\/1664\/1830882\/bio029991.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T10:31:19Z","timestamp":1659868279000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/bio\/article\/6\/11\/1664\/1633\/Amyloid-42-peptide-is-toxic-to-non-neural-cells-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":70,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11,15]]}},"URL":"https:\/\/doi.org\/10.1242\/bio.029991","relation":{},"ISSN":["2046-6390"],"issn-type":[{"value":"2046-6390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]}}}