{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:19:50Z","timestamp":1761401990438,"version":"3.41.2"},"reference-count":48,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":1233,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu?bec - Sant?","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005242","name":"Universit? de Montr?al","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The physiological role and the regulation of ADGRG7 are not yet elucidated. The functional involvement of this receptor was linked with different physiological process such as reduced body weight, gastrointestinal function and recently, a gene variant in ADGRG7 was observed in patients with idiopathic scoliosis. The physiological role and the regulation of Adhesion G protein coupled receptor7 (ADGRG7) are not yet elucidated. The functional involvement of this receptor was linked with different physiological process such as reduced body weight, gastrointestinal function and recently, a gene variant in ADGRG7 was observed in patients with adolescent idiopathic scoliosis. Here, we identify the ADGRG7 as an estrogen-responsive gene under the regulation of estrogen receptor ER\u03b1 in scoliotic osteoblasts and other cells lines. We found that ADGRG7 expression was upregulated in response to estrogen (E2) in adolescent idiopathic scoliosis (AIS) cells. ADGRG7 promoter studies indicate the presence of an ER\u03b1 response half site in close vicinity of an SP1 binding site. Mutation of the SP1 site completely abrogated the response to E2, indicating its essential requirement. ChIP confirmed the binding of SP1 and ER\u03b1 to the ADGRG7 promoter. Our results identify the ADGRG7 gene as an estrogen-responsive gene under the control of ER\u03b1 and SP1 tethered actions, suggesting a possible role of estrogens in the regulation of ADGRG7.<\/jats:p>","DOI":"10.1242\/bio.037390","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T16:05:10Z","timestamp":1546272310000},"source":"Crossref","is-referenced-by-count":6,"title":["The 17\u03b2-Estradiol induced upregulation of the Adhesion G-protein coupled receptor (ADGRG7) is modulated by ESR\u03b1 and SP1 complex"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0677-9938","authenticated-orcid":false,"given":"Amani","family":"Hassan","sequence":"first","affiliation":[{"name":"CHU Sainte Justine Research Center, Montr\u00e9al, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-0488","authenticated-orcid":false,"given":"Edward T.","family":"Bagu","sequence":"additional","affiliation":[{"name":"Department of Basic Biomedical Sciences, Sanford Medical School, University of South Dakota, Vermillion, SD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0273-510X","authenticated-orcid":false,"given":"Mathieu","family":"Levesque","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Research Center, Montr\u00e9al, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunmoogum A.","family":"Patten","sequence":"additional","affiliation":[{"name":"INRS-Institute Armand-Frappier, Laval, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Benhadjeba","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Research Center, Montr\u00e9al, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Edjekouane","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Research Center, Montr\u00e9al, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-0744","authenticated-orcid":false,"given":"Isabelle","family":"Villemure","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Ecole Polytechnique de Montr\u00e9al, Montr\u00e9al, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-9846","authenticated-orcid":false,"given":"Andr\u00e9","family":"Tremblay","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Research Center, Montr\u00e9al, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florina","family":"Moldovan","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Research Center, Montr\u00e9al, Canada"},{"name":"CHU Sainte Justine Research Center and Department of Stomatology, Faculty of Dentistry, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2021042423571160900_BIO037390C1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2012.06820.x","article-title":"Dissecting signaling and functions of adhesion G protein-coupled receptors","volume":"1276","author":"Arac","year":"2012","journal-title":"Ann. 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