{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:00:57Z","timestamp":1772168457040,"version":"3.50.1"},"reference-count":69,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":503,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100006445","name":"National Science Foundation","doi-asserted-by":"publisher","award":["MCB0919709"],"award-info":[{"award-number":["MCB0919709"]}],"id":[{"id":"10.13039\/100006445","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Different stem cells or progenitor cells display variable threshold requirements for functional ribosomes. This is particularly true for several human ribosomopathies in which select embryonic neural crest cells or adult bone marrow stem cells, but not others, show lethality due to failures in ribosome biogenesis or function (now known as nucleolar stress). To determine if various Drosophila neuroblasts display differential sensitivities to nucleolar stress, we used CRISPR-Cas9 to disrupt the Nopp140 gene that encodes two splice variant ribosome biogenesis factors (RBFs). Disruption of Nopp140 induced nucleolar stress that arrested larvae in the second instar stage. While the majority of larval neuroblasts arrested development, the Mushroom Body (MB) neuroblasts continued to proliferate as shown by their maintenance of deadpan, a neuroblast-specific transcription factor, and by their continued EdU incorporation. MB neuroblasts in wild type larvae appeared to contain more fibrillarin and Nopp140 in their nucleoli as compared to other neuroblasts, indicating that MB neuroblasts stockpile RBFs as they proliferate in late embryogenesis while other neuroblasts normally enter quiescence. A greater abundance of Nopp140 encoded by maternal transcripts in Nopp140\u2212\/\u2212 MB neuroblasts of 1-2 day old larvae likely rendered these cells more resilient to nucleolar stress.<\/jats:p>","DOI":"10.1242\/bio.046565","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T15:45:18Z","timestamp":1584459918000},"source":"Crossref","is-referenced-by-count":12,"title":["Nucleolar stress in\n                    <i>Drosophila<\/i>\n                    neuroblasts, a model for human ribosomopathies"],"prefix":"10.1242","author":[{"given":"Sonu Shrestha","family":"Baral","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly E.","family":"Lieux","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2198-1536","authenticated-orcid":false,"given":"Patrick J.","family":"DiMario","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2021042622412164600_BIO046565C1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1080\/01677060802471718","article-title":"The mushroom body of adult Drosophila characterized by GAL4 drivers","volume":"23","author":"Aso","year":"2009","journal-title":"J. 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