{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:03:58Z","timestamp":1772168638943,"version":"3.50.1"},"reference-count":29,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":503,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH112143"],"award-info":[{"award-number":["R01MH112143"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Respiration is controlled by central pattern generating circuits in the brain stem, whose activity can be modulated by inputs from other brain areas to adapt respiration to autonomic and behavioral demands. The cerebellum is known to be part of the neuronal circuitry activated during respiratory challenges, such as hunger for air, but has not been found to be involved in the control of spontaneous, unobstructed breathing (eupnea). Here we applied a measure of intrinsic rhythmicity, the CV2, which evaluates the similarity of subsequent intervals and is thus sensitive to changes in rhythmicity at the temporal resolution of individual respiratory intervals. The variability of intrinsic respiratory rhythmicity was reduced in a mouse model of cerebellar ataxia compared to their healthy littermates. Irrespective of that difference, the average respiratory rate and the average coefficient of variation (CV) were comparable between healthy and ataxic mice. We argue that these findings are consistent with a proposed role of the cerebellum in modulating the duration of individual respiratory intervals, which could serve to purpose of coordinating respiration with other rhythmic orofacial movements, such as fluid licking and swallowing.<\/jats:p>","DOI":"10.1242\/bio.048785","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T13:25:27Z","timestamp":1582291527000},"source":"Crossref","is-referenced-by-count":18,"title":["Loss of cerebellar function selectively affects intrinsic rhythmicity of eupneic breathing"],"prefix":"10.1242","author":[{"given":"Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Anatomy & Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhua","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Anatomy & Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-4870","authenticated-orcid":false,"given":"Fridtjof","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Preventive Medicine., College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany L.","family":"Correia","sequence":"additional","affiliation":[{"name":"Department of Anatomy & Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela P.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Anatomy & Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-6190","authenticated-orcid":false,"given":"Roy V.","family":"Sillitoe","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Department of Neuroscience, and Development, Disease Models & Therapeutics Program, Baylor College of Medicine, Houston, TX; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-4064","authenticated-orcid":false,"given":"Detlef H.","family":"Heck","sequence":"additional","affiliation":[{"name":"Department of Anatomy & Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2021042622410646100_BIO048785C1","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1152\/jn.00586.2014","article-title":"In vivo analysis of Purkinje cell firing properties during postnatal mouse development","volume":"113","author":"Arancillo","year":"2015","journal-title":"J. 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