{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:20:06Z","timestamp":1755696006121,"version":"3.41.2"},"reference-count":35,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":503,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401180"],"award-info":[{"award-number":["81401180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Advanced oxidation protein products (AOPPs) are a family of oxidized protein compounds and could induce oxidative stress and inflammatory lesion in various cells. The accumulation of AOPPs was associated with female reproduction diseases such as PCOS, leiomyoma and endometriosis. However, the relationship between AOPPs and the endometrial cells is unclear. To explore the effects accumulated AOPPs on endometrial cells, we treated normal rats endometrial epithelial cells (rEECs) and endometriosis model rats with AOPP. Primary rEECs were collected from 8-weeks-old female Wistar rats. Increasing the amount of AOPPs in the media of rEECs could enhanced rEECs proliferation and migration, and inhibited apoptosis. Moreover, AOPPs triggered the production of reactive oxygen species and nitrite by ERK and P38 signal and this, in turn, led to an upregulation of proliferation and migration. With the treatment of antioxidants or the inhibitors of ERK and P38, the above effects of AOPPs on rEECs were attenuated. Additionally, in endometriosis rats model, the similar phenomena was observed that the growth of endometriotic implants were promoted by AOPPs and EECs were significantly increased. This study indicated that the accumulation of AOPPs could promote rEECs proliferation and migration through ERK and P38 signal both in vivo and in vitro.<\/jats:p>","DOI":"10.1242\/bio.048876","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T14:49:26Z","timestamp":1588603766000},"source":"Crossref","is-referenced-by-count":7,"title":["Advanced oxidation protein products change biological behaviors of rats endometrial epithelial cells by activating ERK\/P38 signaling pathways"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4389-0918","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-8851","authenticated-orcid":false,"given":"Sixi","family":"Wen","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3215-0890","authenticated-orcid":false,"given":"Yanling","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8943-3755","authenticated-orcid":false,"given":"Xiaoping","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-0381","authenticated-orcid":false,"given":"Zebang","family":"Liu","sequence":"additional","affiliation":[{"name":"Huazhong Agriculture University, Wuhan 430000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Quan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. 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