{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:45:51Z","timestamp":1777531551779,"version":"3.51.4"},"reference-count":62,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":178,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FCE_3_2013_1_100732"],"award-info":[{"award-number":["FCE_3_2013_1_100732"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa de Desarrollo de las Ciencias B\u00e1sicas"},{"DOI":"10.13039\/501100013395","name":"Sistema Nacional de Investigadores","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013395","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swiss University Conference","award":["P-01 BIO BEFRI"],"award-info":[{"award-number":["P-01 BIO BEFRI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Environmental factors such as the availability of oxygen are instructive cues that regulate stem cell maintenance and differentiation. We used a genetically encoded biosensor to monitor the hypoxic state of neural cells in the larval brain of Drosophila. The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that is observed throughout development between the central brain and the optic lobe. Neural stem cells in both compartments show the strongest hypoxia response while intermediate progenitors, neurons and glial cells reveal weaker responses. We demonstrate that the distance between a cell and the next closest tracheole is a good predictor of the hypoxic state of that cell. Our study indicates that oxygen availability appears to be the major factor controlling the hypoxia response in the developing Drosophila brain and that cell intrinsic and cell-type specific factors contribute to modulate the response in an unexpected manner.<\/jats:p>\n                  <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/bio.053629","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T09:46:28Z","timestamp":1597743988000},"source":"Crossref","is-referenced-by-count":12,"title":["Compartment and cell-type specific hypoxia responses in the developing\n                    <i>Drosophila<\/i>\n                    brain"],"prefix":"10.1242","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4143-4166","authenticated-orcid":false,"given":"Martin","family":"Baccino-Calace","sequence":"first","affiliation":[{"name":"Developmental Neurobiology, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8356-1708","authenticated-orcid":false,"given":"Daniel","family":"Prieto","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Cantera","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, Montevideo 11600, Uruguay"},{"name":"Zoology Department, Stockholm University, Stockholm 106 91, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-9140","authenticated-orcid":false,"given":"Boris","family":"Egger","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Fribourg, Fribourg CH-1700, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"2021042700294024100_BIO053629C1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1006\/dbio.2002.0740","article-title":"gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila","volume-title":"Dev. Biol.","author":"Alfonso","year":"2002"},{"key":"2021042700294024100_BIO053629C2","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.cell.2015.09.020","article-title":"Antioxidant role for lipid droplets in a stem cell niche of Drosophila","volume":"163","author":"Bailey","year":"2015","journal-title":"Cell"},{"key":"2021042700294024100_BIO053629C3","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1159\/000146222","article-title":"Division of type I and endothelial cells in the hypoxic rat carotid body","volume":"126","author":"Bee","year":"1986","journal-title":"Acta Anat. (Basel)."},{"key":"2021042700294024100_BIO053629C4","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/0022-1910(82)90112-3","article-title":"Ovarian yolk-protein synthesis in Drosophila melanogaster","volume":"28","author":"Bownes","year":"1982","journal-title":"J. Insect Physiol."},{"key":"2021042700294024100_BIO053629C5","doi-asserted-by":"publisher","first-page":"4334","DOI":"10.1242\/jeb.093120","article-title":"The role of reduced oxygen in the developmental physiology of growth and metamorphosis initiation in Drosophila melanogaster","volume":"216","author":"Callier","year":"2013","journal-title":"J. Exp. Biol."},{"key":"2021042700294024100_BIO053629C6","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1242\/dev.120.10.2957","article-title":"RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila","volume":"120","author":"Campbell","year":"1994","journal-title":"Development"},{"issue":"Suppl. 1","key":"2021042700294024100_BIO053629C7","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1002\/bies.201670911","article-title":"The hypoxic microenvironment: a determinant of cancer stem cell evolution","volume":"38","author":"Carnero","year":"2016","journal-title":"BioEssays"},{"key":"2021042700294024100_BIO053629C8","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.devcel.2008.01.020","article-title":"Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting","volume":"14","author":"Centanin","year":"2008","journal-title":"Dev. Cell"},{"key":"2021042700294024100_BIO053629C9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.neuron.2013.12.021","article-title":"Cell-type-specific labeling of synapses in vivo through synaptic tagging with recombination","volume":"81","author":"Chen","year":"2014","journal-title":"Neuron"},{"key":"2021042700294024100_BIO053629C10","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1182\/blood.V82.7.2031.2031","article-title":"The role of hypoxia in the maintenance of hematopoietic stem cells","volume":"82","author":"Cipolleschi","year":"1993","journal-title":"Blood"},{"key":"2021042700294024100_BIO053629C11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1334.001","article-title":"Oxygen in the cultivation of stem cells","volume":"1049","author":"Csete","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2021042700294024100_BIO053629C12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1749-8104-2-1","article-title":"Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe","volume":"2","author":"Egger","year":"2007","journal-title":"Neural Develop"},{"key":"2021042700294024100_BIO053629C13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.exphem.2010.01.005","article-title":"Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture","volume":"38","author":"Eliasson","year":"2010","journal-title":"Exp. Hematol."},{"key":"2021042700294024100_BIO053629C14","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1534\/g3.119.400715","article-title":"Unpredictable effects of the genetic background of transgenic lines in physiological quantitative traits","volume":"9","author":"Evangelou","year":"2019","journal-title":"G3 (Bethesda)"},{"key":"2021042700294024100_BIO053629C15","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.1073\/pnas.0501283102","article-title":"Low O2 tensions and the prevention of differentiation of hES cells","volume":"102","author":"Ezashi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042700294024100_BIO053629C16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-0-387-78261-4_8","article-title":"Optic lobe development","volume":"628","author":"Fischbach","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"2021042700294024100_BIO053629C17","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/BF00333712","article-title":"The embryonic development of the Drosophila visual system","volume":"273","author":"Green","year":"1993","journal-title":"Cell Tissue Res."},{"key":"2021042700294024100_BIO053629C18","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.devcel.2005.09.010","article-title":"Hypoxia requires notch signaling to maintain the undifferentiated cell state","volume":"9","author":"Gustafsson","year":"2005","journal-title":"Dev. Cell"},{"key":"2021042700294024100_BIO053629C19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1146\/annurev-physiol-012110-142155","article-title":"Effects of oxygen on growth and size: synthesis of molecular, organismal, and evolutionary studies with Drosophila melanogaster","volume":"73","author":"Harrison","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"2021042700294024100_BIO053629C20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-0-387-78261-4_1","article-title":"The development of the Drosophila larval brain","volume":"628","author":"Hartenstein","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"2021042700294024100_BIO053629C21","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1242\/dev.058370","article-title":"Concentric zones, cell migration and neuronal circuits in the Drosophila visual center","volume":"138","author":"Hasegawa","year":"2011","journal-title":"Development"},{"key":"2021042700294024100_BIO053629C22","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/BF00377393","article-title":"Proliferation pattern and early differentiation of the optic lobes in Drosophila melanogaster","volume":"198","author":"Hofbauer","year":"1990","journal-title":"Roux's Arch. Dev. Biol."},{"key":"2021042700294024100_BIO053629C23","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1080\/01677060802471627","article-title":"The Wuerzburg hybridoma library against Drosophila brain","volume":"23","author":"Hofbauer","year":"2009","journal-title":"J. Neurogenet."},{"key":"2021042700294024100_BIO053629C24","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.cell.2014.06.024","article-title":"Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells","volume":"158","author":"Homem","year":"2014","journal-title":"Cell"},{"key":"2021042700294024100_BIO053629C25","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1002\/cne.21133","article-title":"Modular neuropile organization in the Drosophila larval brain facilitates identification and mapping of central neurons","volume":"499","author":"Iyengar","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"2021042700294024100_BIO053629C26","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0092-8674(00)81652-9","article-title":"Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF","volume":"99","author":"Jarecki","year":"1999","journal-title":"Cell"},{"key":"2021042700294024100_BIO053629C27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrm2319","article-title":"No place like home: anatomy and function of the stem cell niche","volume":"9","author":"Jones","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042700294024100_BIO053629C28","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1126\/science.1126308","article-title":"Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release","volume":"312","author":"Kittel","year":"2006","journal-title":"Science"},{"key":"2021042700294024100_BIO053629C29","doi-asserted-by":"publisher","first-page":"924","DOI":"10.15252\/embj.201592372","article-title":"Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis","volume":"35","author":"Lange","year":"2016","journal-title":"EMBO J."},{"key":"2021042700294024100_BIO053629C30","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ceb.2012.01.005","article-title":"From stem cells to cancer stem cells: HIF takes the stage","volume":"24","author":"Lee","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"key":"2021042700294024100_BIO053629C31","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1038\/s41467-019-09643-7","article-title":"TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila","volume":"10","author":"Lee","year":"2019","journal-title":"Nat. Commun."},{"key":"2021042700294024100_BIO053629C32","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1146\/annurev.cellbio.21.012704.131525","article-title":"Stem cell niche: structure and function","volume":"21","author":"Li","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2021042700294024100_BIO053629C33","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.devcel.2012.12.010","article-title":"Trachea-derived dpp controls adult midgut homeostasis in Drosophila","volume":"24","author":"Li","year":"2013","journal-title":"Dev. Cell"},{"key":"2021042700294024100_BIO053629C34","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1093\/bioinformatics\/btr390","article-title":"Simple Neurite Tracer: open source software for reconstruction, visualization and analysis of neuronal processes","volume":"27","author":"Longair","year":"2011","journal-title":"Bioinformatics"},{"key":"2021042700294024100_BIO053629C35","first-page":"1363","article-title":"The development of the optic lobe","volume-title":"The Development of Drosophila Melanogaster","author":"Meinertzhagen","year":"1993"},{"key":"2021042700294024100_BIO053629C36","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1002\/dneu.20894","article-title":"Visual circuit assembly in Drosophila","volume":"71","author":"Melnattur","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"2021042700294024100_BIO053629C37","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1242\/bio.018226","article-title":"A genetically encoded biosensor for visualising hypoxia responses in vivo","volume":"6","author":"Misra","year":"2017","journal-title":"Biol. Open"},{"key":"2021042700294024100_BIO053629C38","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.stem.2010.07.007","article-title":"Oxygen in stem cell biology: a critical component of the stem cell niche","volume":"7","author":"Mohyeldin","year":"2010","journal-title":"Cell Stem Cell"},{"key":"2021042700294024100_BIO053629C39","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.cell.2008.01.038","article-title":"Stem cells and niches: mechanisms that promote stem cell maintenance throughout life","volume":"132","author":"Morrison","year":"2008","journal-title":"Cell"},{"key":"2021042700294024100_BIO053629C40","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1006\/dbio.1997.8539","article-title":"Role of basic FGF and oxygen in control of proliferation, survival, and neuronal differentiation in carotid body chromaffin cells","volume":"184","author":"Nurse","year":"1997","journal-title":"Dev. Biol."},{"key":"2021042700294024100_BIO053629C41","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0092-8674(94)90580-0","article-title":"The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras\/MAPK pathway","volume":"78","author":"O'Neill","year":"1994","journal-title":"Cell"},{"key":"2021042700294024100_BIO053629C42","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/jcp.21812","article-title":"The role of oxygen in regulating neural stem cells in development and disease","volume":"220","author":"Panchision","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"2021042700294024100_BIO053629C43","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.cell.2007.07.043","article-title":"Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body","volume":"131","author":"Pardal","year":"2007","journal-title":"Cell"},{"key":"2021042700294024100_BIO053629C44","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ydbio.2006.09.022","article-title":"Tracheal development in the Drosophila brain is constrained by glial cells","volume":"302","author":"Pereanu","year":"2007","journal-title":"Dev. Biol."},{"key":"2021042700294024100_BIO053629C45","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.celrep.2016.05.082","article-title":"The TIP60 complex is a conserved coactivator of HIF1A","volume":"16","author":"Perez-Perri","year":"2016","journal-title":"Cell Rep"},{"key":"2021042700294024100_BIO053629C46","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2014.11.043","article-title":"Subcellular trafficking of FGF controls tracheal invasion of Drosophila flight muscle","volume":"160","author":"Peterson","year":"2015","journal-title":"Cell"},{"key":"2021042700294024100_BIO053629C47","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1038\/nature04957","article-title":"The stem-cell niche as an entity of action","volume":"441","author":"Scadden","year":"2006","journal-title":"Nature"},{"key":"2021042700294024100_BIO053629C48","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2021042700294024100_BIO053629C49","first-page":"7","article-title":"The relationship between the spleen colony-forming cell and the haemopoietic stem cell","volume":"4","author":"Schofield","year":"1978","journal-title":"Blood Cells"},{"key":"2021042700294024100_BIO053629C50","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nrm2354","article-title":"The role of oxygen availability in embryonic development and stem cell function","volume":"9","author":"Simon","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042700294024100_BIO053629C51","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.stem.2010.07.011","article-title":"The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche","volume":"7","author":"Simsek","year":"2010","journal-title":"Cell Stem Cell"},{"key":"2021042700294024100_BIO053629C52","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.devcel.2013.05.020","article-title":"Cell-type-specific profiling of gene expression and chromatin binding without cell isolation: assaying RNA Pol II occupancy in neural stem cells","volume":"26","author":"Southall","year":"2013","journal-title":"Dev. Cell"},{"key":"2021042700294024100_BIO053629C53","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1006\/exnr.2001.7706","article-title":"Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells","volume":"170","author":"Storch","year":"2001","journal-title":"Exp. Neurol."},{"key":"2021042700294024100_BIO053629C54","doi-asserted-by":"publisher","first-page":"7377","DOI":"10.1523\/JNEUROSCI.20-19-07377.2000","article-title":"Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen","volume":"20","author":"Studer","year":"2000","journal-title":"J. Neurosci."},{"key":"2021042700294024100_BIO053629C55","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.stem.2010.06.020","article-title":"Regulation of the HIF-1alpha level is essential for hematopoietic stem cells","volume":"7","author":"Takubo","year":"2010","journal-title":"Cell Stem Cell"},{"key":"2021042700294024100_BIO053629C62","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1242\/dev.020685","article-title":"Smt3 is required for Drosophila melanogaster metamorphosis","volume":"135","author":"Talamillo","year":"2008","journal-title":"Development"},{"key":"2021042700294024100_BIO053629C56","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1038\/s41467-019-09943-y","article-title":"A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion","volume":"10","author":"Texada","year":"2019","journal-title":"Nat. Commun."},{"key":"2021042700294024100_BIO053629C57","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0012-1606(88)90067-X","article-title":"Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster","volume":"125","author":"Truman","year":"1988","journal-title":"Dev. Biol."},{"key":"2021042700294024100_BIO053629C58","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.neuron.2006.02.008","article-title":"Bruchpilot, a protein with homology to ELKS\/CAST, is required for structural integrity and function of synaptic active zones in Drosophila","volume":"49","author":"Wagh","year":"2006","journal-title":"Neuron"},{"key":"2021042700294024100_BIO053629C59","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/0012-1606(78)90029-5","article-title":"Patterns of cell division and cell movement in the formation of the imaginal nervous system in Drosophila melanogaster","volume":"65","author":"White","year":"1978","journal-title":"Dev. Biol."},{"key":"2021042700294024100_BIO053629C60","doi-asserted-by":"publisher","first-page":"e115297","DOI":"10.1371\/journal.pone.0115297","article-title":"Insulin- and warts-dependent regulation of tracheal plasticity modulates systemic larval growth during hypoxia in Drosophila melanogaster","volume":"9","author":"Wong","year":"2014","journal-title":"PLoS ONE"},{"key":"2021042700294024100_BIO053629C61","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1242\/dev.019117","article-title":"Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK\/STAT","volume":"135","author":"Yasugi","year":"2008","journal-title":"Development"}],"container-title":["Biology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/bio.053629","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.logists.com\/bio\/bio\/article-pdf\/doi\/10.1242\/bio.053629\/1836259\/bio053629.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.logists.com\/bio\/bio\/article-pdf\/doi\/10.1242\/bio.053629\/1836259\/bio053629.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T22:29:51Z","timestamp":1619476191000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/bio\/article\/9\/8\/bio053629\/225330\/Compartment-and-cell-type-specific-hypoxia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,15]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,15]]}},"URL":"https:\/\/doi.org\/10.1242\/bio.053629","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2019.12.12.874404","asserted-by":"object"}]},"ISSN":["2046-6390"],"issn-type":[{"value":"2046-6390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,15]]},"article-number":"bio053629"}}