{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:44:00Z","timestamp":1788248640503,"version":"build-2803163510"},"reference-count":54,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":503,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["PGC2018-101226-B-I00"],"award-info":[{"award-number":["PGC2018-101226-B-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Hypoxia could be a possible risk factor for neurodegenerative alterations in cetaceans\u2019 brain. Among toothed whales, the beaked whales are particularly cryptic and routinely dive deeper than 1,000 m for about one hour in order to hunt squids and fishes.<\/jats:p>\n                  <jats:p>Samples of frontal cerebral and cerebellar cortex were collected from nine animals, representing six different species of the suborder Odontoceti. Immunohistochemical analysis employed anti-\u03b2-amyloid (A\u03b2) and anti-neurofibrillary tangle (NFT) antibodies. Six of nine (67%) animals showed positive immunolabeling for A\u03b2 and\/or NFT. The most striking findings were intranuclear A\u03b2 immunopositivity in cerebral cortical neurons and NFT immunopositivity in cerebellar Purkinje neurons with granulovacuolar degeneration. A\u03b2 plaques were also observed in one elderly animal.<\/jats:p>\n                  <jats:p>Herein, we present immunohistopathological findings classic of Alzheimer's and other neurodegenerative diseases in humans. Our findings could be linked to hypoxic phenomena, as they were more extensive in beaked whales. Despite their adaptations, cetaceans could be vulnerable to sustained and repetitive brain hypoxia.<\/jats:p>","DOI":"10.1242\/bio.054734","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T14:35:14Z","timestamp":1602254114000},"source":"Crossref","is-referenced-by-count":17,"title":["Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging\n                    <i>vs<\/i>\n                    hypoxia"],"prefix":"10.1242","author":[{"given":"Simona","family":"Sacchini","sequence":"first","affiliation":[{"name":"Veterinary Histology and Pathology, Institute of Animal Health, University of Las Palmas de Gran Canaria, Veterinary School, c\/Transmonta\u00f1a s\/n, 35416, Arucas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"D\u00edaz-Delgado","sequence":"additional","affiliation":[{"name":"Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Brazil"},{"name":"Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX 77843, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Espinosa de los Monteros","sequence":"additional","affiliation":[{"name":"Veterinary Histology and Pathology, Institute of Animal Health, University of Las Palmas de Gran Canaria, Veterinary School, c\/Transmonta\u00f1a s\/n, 35416, Arucas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yania","family":"Paz","sequence":"additional","affiliation":[{"name":"Veterinary Histology and Pathology, Institute of Animal Health, University of Las Palmas de Gran Canaria, Veterinary School, c\/Transmonta\u00f1a s\/n, 35416, Arucas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara","family":"Bernaldo de Quir\u00f3s","sequence":"additional","affiliation":[{"name":"Veterinary Histology and Pathology, Institute of Animal Health, University of Las Palmas de Gran Canaria, Veterinary School, c\/Transmonta\u00f1a s\/n, 35416, Arucas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sierra","sequence":"additional","affiliation":[{"name":"Veterinary Histology and Pathology, Institute of Animal Health, University of Las Palmas de Gran Canaria, Veterinary School, c\/Transmonta\u00f1a s\/n, 35416, Arucas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Arbelo","sequence":"additional","affiliation":[{"name":"Veterinary Histology and Pathology, Institute of Animal Health, University of Las Palmas de Gran Canaria, Veterinary School, c\/Transmonta\u00f1a s\/n, 35416, Arucas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Herr\u00e1ez","sequence":"additional","affiliation":[{"name":"Veterinary Histology and Pathology, Institute of Animal Health, University of Las Palmas de Gran Canaria, Veterinary School, c\/Transmonta\u00f1a s\/n, 35416, Arucas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Veterinary Histology and Pathology, Institute of Animal Health, University of Las Palmas de Gran Canaria, Veterinary School, c\/Transmonta\u00f1a s\/n, 35416, Arucas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2021042700295909800_BIO054734C1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3354\/dao02558","article-title":"Pathology and causes of death of stranded cetaceans in the Canary Islands (1999-2005)","volume":"103","author":"Arbelo","year":"2013","journal-title":"Dis. 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