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However, not much is known about the mechanism leading to the regulation of these surface proteins. In this study, we found that the Drosophila BRAG GEF Schizo interacts physically with the Abl-interactor (Abi). schizo mutants display severe defects in myoblast fusion during syncytial muscle formation and show increased amounts of the cell adhesion protein N-cadherin. We demonstrate that the schizo myoblast fusion phenotype can be rescued by the expression of the Schizo GEF (Sec7) and membrane-binding (pleckstrin homology) domain. Furthermore, the expression of the Sec7-PH domain in a wild-type background decreases the amounts of N-cadherin and impairs myoblast fusion. These findings support the notion that the Sec7-PH domain serves as a constitutive-active form of Schizo. Using a yeast-two hybrid assay, we show that the SH3 domain of Abi interacts with the N-terminal region of Schizo. This region is also able to bind to the cytodomain of the cell adhesion molecule N-cadherin. To shed light on the function of Schizo and Abi in N-cadherin removal, we employed epistasis experiments in different developmental contexts of Drosophila. These studies point towards a new model for the regulation of Schizo. We propose that the binding of Abi to the N-terminal part of Schizo antagonizes Schizo function to inhibit N-cadherin removal.<\/jats:p>","DOI":"10.1242\/bio.058666","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T06:25:34Z","timestamp":1639376734000},"source":"Crossref","is-referenced-by-count":0,"title":["The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo"],"prefix":"10.1242","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-2666","authenticated-orcid":false,"given":"Stefanie","family":"L\u00fcbke","sequence":"first","affiliation":[{"name":"Fachbereich Medizin, Department for Molecular Cell Physiology, Institute for Physiology and Pathophysiology, Philipps-Universit\u00e4t Marburg 1 , Emil-Mannkopff-Str. 2, 35037 Marburg , Germany"},{"name":"Fachbereich Biologie, Department for Developmental Biology, Philipps-Universit\u00e4t Marburg 2 , Karl-von-Frisch-Str. 8, 35043 Marburg , Germany"},{"name":"DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodeling, GRK 2213, Philipps-Universit\u00e4t Marburg 3 , Marburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7203-5681","authenticated-orcid":false,"given":"Carina","family":"Braukmann","sequence":"additional","affiliation":[{"name":"Fachbereich Biologie, Department for Developmental Biology, Philipps-Universit\u00e4t Marburg 2 , Karl-von-Frisch-Str. 8, 35043 Marburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5513-6576","authenticated-orcid":false,"given":"Karl-Heinz","family":"Rexer","sequence":"additional","affiliation":[{"name":"Fachbereich Biologie, Department for Biodiversity of Plants, Philipps-Universit\u00e4t Marburg 4 , Karl-von-Frisch-Str. 8, 35043 Marburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubjinka","family":"Cigoja","sequence":"additional","affiliation":[{"name":"Fachbereich Biologie, Department for Developmental Biology, Philipps-Universit\u00e4t Marburg 2 , Karl-von-Frisch-Str. 8, 35043 Marburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratiti","family":"Rout","sequence":"additional","affiliation":[{"name":"DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodeling, GRK 2213, Philipps-Universit\u00e4t Marburg 3 , Marburg , Germany"},{"name":"Fachbereich Biologie, Department for Molecular Embryology, Philipps-Universit\u00e4t Marburg 5 , Karl-von-Frisch-Str. 8, 35043 Marburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3081-477X","authenticated-orcid":false,"given":"Susanne F.","family":"\u00d6nel","sequence":"additional","affiliation":[{"name":"Fachbereich Medizin, Department for Molecular Cell Physiology, Institute for Physiology and Pathophysiology, Philipps-Universit\u00e4t Marburg 1 , Emil-Mannkopff-Str. 2, 35037 Marburg , Germany"},{"name":"Fachbereich Biologie, Department for Developmental Biology, Philipps-Universit\u00e4t Marburg 2 , Karl-von-Frisch-Str. 8, 35043 Marburg , Germany"},{"name":"DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodeling, GRK 2213, Philipps-Universit\u00e4t Marburg 3 , Marburg , Germany"},{"name":"Fachbereich Biologie, Department for Molecular Embryology, Philipps-Universit\u00e4t Marburg 5 , Karl-von-Frisch-Str. 8, 35043 Marburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"2024010809504638800_BIO058666C1","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1242\/dev.068353","article-title":"Myoblast fusion: lessons from flies and mice","volume":"139","author":"Abmayr","year":"2012","journal-title":"Development"},{"key":"2024010809504638800_BIO058666C2","doi-asserted-by":"publisher","first-page":"e1001652","DOI":"10.1371\/journal.pbio.1001652","article-title":"Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2","volume":"11","author":"Aizel","year":"2013","journal-title":"PLoS Biol."},{"key":"2024010809504638800_BIO058666C3","doi-asserted-by":"publisher","first-page":"a031534","DOI":"10.1101\/cshperspect.a031534","article-title":"The interdependent activation of Son-of-Sevenless and Ras","volume":"9","author":"Bandaru","year":"2019","journal-title":"Cold Spring Harb. 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