{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:15:19Z","timestamp":1784128519473,"version":"3.55.0"},"reference-count":147,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323"],"award-info":[{"award-number":["HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"crossref","award":["Action EU-CARDIOPROTECTION CA16225"],"award-info":[{"award-number":["Action EU-CARDIOPROTECTION CA16225"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell\u2013cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectly through the exchange of soluble factors and extracellular vesicles (EV), and by cell\u2013extracellular matrix (ECM) interactions. GJ-mediated communication between cardiomyocytes and with other cardiac cell types enables electrical impulse propagation, required to sustain synchronized heart beating. In addition, TNT-mediated organelle transfer has been associated with cardioprotection, whilst communication via EV plays diverse pathophysiological roles, being implicated in angiogenesis, inflammation and fibrosis. Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction and hypertrophy, highlighting the importance of a comprehensive and integrated view of complex cell communication networks. In this review, I intend to provide a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example.<\/jats:p>\n               <jats:p>This Review has an associated Future Leader to Watch interview with the author.<\/jats:p>","DOI":"10.1242\/bio.058777","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T10:05:47Z","timestamp":1631095547000},"source":"Crossref","is-referenced-by-count":24,"title":["Connecting different heart diseases through intercellular communication"],"prefix":"10.1242","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-3923","authenticated-orcid":false,"given":"Tania","family":"Martins-Marques","sequence":"first","affiliation":[{"name":"Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, 3000-548 Coimbra, Portugal"},{"name":"Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Centre of Coimbra (CACC), 3004-561 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"2021091613271998100_BIO058777C1","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1002\/stem.632","article-title":"Human mesenchymal stem cells reprogram adult cardiomyocytes toward a progenitor-like state through partial cell fusion and mitochondria transfer","volume":"29","author":"Acquistapace","year":"2011","journal-title":"Stem Cells"},{"key":"2021091613271998100_BIO058777C2","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1111\/jcmm.14014","article-title":"Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation","volume":"23","author":"Almeida Paiva","year":"2019","journal-title":"J. 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