{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:19:56Z","timestamp":1784225996996,"version":"3.55.0"},"reference-count":0,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P20GM121334"],"award-info":[{"award-number":["P20GM121334"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The nuclear factor-Kappa B (NF-\u03baB) pathway is a crucial mediator of inflammatory signaling. Aberrant activation of NF-\u03baB is associated with several disorders including preeclampsia (PE). Many regulators of the NF-\u03baB pathway have been identified, including microRNAs (miRNAs). Specifically, miR-517-3p targets mRNA encoding TNFAIP3 Interacting Protein 1 (TNIP1), an inhibitor of NF-\u03baB signaling. Activation of NF-\u03baB increases production of the cytokine TNF superfamily member 15 (TNFSF15), leading to the upregulation of anti-angiogenic soluble vascular endothelial growth factor receptor 1 (sFlt-1). We have previously observed that Cajal bodies (CBs), subnuclear domains, are associated with the chromosome 19 miRNA gene cluster (C19MC) which encodes miR-517-3p. We have also found that coilin, the CB marker protein, is a positive regulator of miRNA biogenesis. Here we report that coilin is a regulator of miR-517-3p, sFlt-1, TNIP1, TNFSF15 and NF-\u03baB activation, and this regulation is influenced by hypoxia. We also report that coilin and CBs are induced in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia. Collectively, the data presented here implicate coilin as a novel regulator of NF-\u03baB activation and sFlt-1 upregulation.<\/jats:p>","DOI":"10.1242\/bio.059326","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T13:49:25Z","timestamp":1656424165000},"source":"Crossref","is-referenced-by-count":10,"title":["Coilin as a regulator of NF-kB mediated inflammation in preeclampsia"],"prefix":"10.1242","author":[{"given":"Madelyn K.","family":"Logan","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, The University of Mississippi Medical Center, Jackson, MS 39216-4505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katheryn E.","family":"Lett","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, The University of Mississippi Medical Center, Jackson, MS 39216-4505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M.","family":"McLaurin","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, The University of Mississippi Medical Center, Jackson, MS 39216-4505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6233-9654","authenticated-orcid":false,"given":"Michael D.","family":"Hebert","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, The University of Mississippi Medical Center, Jackson, MS 39216-4505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,6,28]]},"container-title":["Biology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.logists.com\/bio\/bio\/article-pdf\/doi\/10.1242\/bio.059326\/2150370\/bio059326.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.logists.com\/bio\/bio\/article-pdf\/doi\/10.1242\/bio.059326\/2150370\/bio059326.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T13:49:26Z","timestamp":1656424166000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/bio\/article\/doi\/10.1242\/bio.059326\/275810\/Coilin-as-a-regulator-of-NF-kB-mediated"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1242\/bio.059326","relation":{},"ISSN":["2046-6390"],"issn-type":[{"value":"2046-6390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,28]]},"article-number":"bio.059326"}}