{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:31:50Z","timestamp":1781508710623,"version":"3.54.1"},"reference-count":29,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004722","name":"Stiftelsen Lars Hiertas Minne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Research Council"},{"DOI":"10.13039\/501100007051","name":"Uppsala Universitet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Formation of the mouse cerebellum is initiated in the embryo and continues for a few weeks after birth. Double-mutant mice lacking platelet-derived growth factor C (PDGF-C) and that are heterozygous for platelet-derived growth factor receptor alpha (Pdgfc-\/-; PdgfraGFP\/+) develop cerebellar hypoplasia and malformation with loss of cerebellar lobes in the posterior vermis. This phenotype is similar to those observed in Foxc1 mutant mice and in a human neuroimaging pattern called Dandy Walker malformation. Pdgfc-Pdgfra mutant mice also display ependymal denudation in the fourth ventricle and gene expression changes in cerebellar meninges, which coincide with the first visible signs of cerebellar malformation. Here, we show that PDGF-C\/PDGFR\u03b1 signalling is a critical component in the network of molecular and cellular interactions that take place between the developing meninges and neural tissues, and which are required to build a fully functioning cerebellum.<\/jats:p>","DOI":"10.1242\/bio.059431","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T14:43:15Z","timestamp":1658760195000},"source":"Crossref","is-referenced-by-count":7,"title":["Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C\/PDGFR\u03b1 signalling in cerebellar development"],"prefix":"10.1242","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6696-7706","authenticated-orcid":false,"given":"Sara","family":"Gilln\u00e4s","sequence":"first","affiliation":[{"name":"Rudbeck Laboratory, Uppsala University Department of Immunology, Genetics and Pathology , , Dag Hammarskj\u00f6lds v\u00e4g 20, SE-75185 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-3337","authenticated-orcid":false,"given":"Radiosa","family":"Gallini","sequence":"additional","affiliation":[{"name":"Rudbeck Laboratory, Uppsala University Department of Immunology, Genetics and Pathology , , Dag Hammarskj\u00f6lds v\u00e4g 20, SE-75185 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-7597","authenticated-orcid":false,"given":"Liqun","family":"He","sequence":"additional","affiliation":[{"name":"Rudbeck Laboratory, Uppsala University Department of Immunology, Genetics and Pathology , , Dag Hammarskj\u00f6lds v\u00e4g 20, SE-75185 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8494-971X","authenticated-orcid":false,"given":"Christer","family":"Betsholtz","sequence":"additional","affiliation":[{"name":"Rudbeck Laboratory, Uppsala University Department of Immunology, Genetics and Pathology , , Dag Hammarskj\u00f6lds v\u00e4g 20, SE-75185 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-4381","authenticated-orcid":false,"given":"Johanna","family":"Andrae","sequence":"additional","affiliation":[{"name":"Rudbeck Laboratory, Uppsala University Department of Immunology, Genetics and Pathology , , Dag Hammarskj\u00f6lds v\u00e4g 20, SE-75185 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"2022080914241762100_BIO059431C1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.siny.2016.04.008","article-title":"The genetics of cerebellar malformations","volume":"21","author":"Aldinger","year":"2016","journal-title":"Semin. 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