{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:02:59Z","timestamp":1772168579929,"version":"3.50.1"},"reference-count":47,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010311","name":"Core","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010311","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Johns Hopkins University","award":["T32AI083216"],"award-info":[{"award-number":["T32AI083216"]}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The adherens junction component, alpha-T-catenin (\u03b1Tcat) is an established contributor to cardiomyocyte junction structure and function, but recent genomic studies link CTNNA3 polymorphisms to diseases with no clear cardiac underpinning, including asthma, autism and multiple sclerosis, suggesting causal contributions from a different cell-type. We show Ctnna3 mRNA is highly expressed in peripheral nerves (e.g. vagus and sciatic), where \u03b1Tcat protein enriches at paranodes and myelin incisure adherens junctions of Schwann cells. We validate \u03b1Tcat immunodetection specificity using a new Ctnna3-knock-out fluorescence reporter mouse line yet find no obvious Schwann cell loss-of-function morphology at the light microscopic level. CTNNA3\/Ctnna3 mRNA is also abundantly detected in oligodendrocytes of the central nervous system via public databases, supporting a general role for \u03b1Tcat in these unique cell\u2013cell junctions. These data suggest that the wide range of diseases linked to CTNNA3 may be through its role in maintaining neuroglial functions of central and peripheral nervous systems.<\/jats:p>\n                  <jats:p>This article has a corresponding First Person interview with the co-first authors of the paper.<\/jats:p>","DOI":"10.1242\/bio.059634","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T06:30:57Z","timestamp":1669271457000},"source":"Crossref","is-referenced-by-count":6,"title":["Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions"],"prefix":"10.1242","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-8861","authenticated-orcid":false,"given":"Anthea","family":"Weng","sequence":"first","affiliation":[{"name":"Northwestern University, Feinberg School of Medicine 1 Department of Pulmonary Medicine , , Chicago, IL 60611 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-6482","authenticated-orcid":false,"given":"Erik E.","family":"Rabin","sequence":"additional","affiliation":[{"name":"Northwestern University, Feinberg School of Medicine 1 Department of Pulmonary Medicine , , Chicago, IL 60611 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette S.","family":"Flozak","sequence":"additional","affiliation":[{"name":"Northwestern University, Feinberg School of Medicine 1 Department of Pulmonary Medicine , , Chicago, IL 60611 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-4929","authenticated-orcid":false,"given":"Sergio E.","family":"Chiarella","sequence":"additional","affiliation":[{"name":"Northwestern University, Feinberg School of Medicine 1 Department of Pulmonary Medicine , , Chicago, IL 60611 , USA"},{"name":"Mayo Clinic 3 , Rochester, MN 55902 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul Piseaux","family":"Aillon","sequence":"additional","affiliation":[{"name":"Northwestern University, Feinberg School of Medicine 1 Department of Pulmonary Medicine , , Chicago, IL 60611 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-7617","authenticated-orcid":false,"given":"Cara J.","family":"Gottardi","sequence":"additional","affiliation":[{"name":"Northwestern University, Feinberg School of Medicine 1 Department of Pulmonary Medicine , , Chicago, IL 60611 , USA"},{"name":"Northwestern University, Feinberg School of Medicine 2 Cell & Developmental Biology , , Chicago, IL 60611 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"2023020614451207100_BIO059634C1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1866-1955-6-17","article-title":"A CTNNA3 compound heterozygous deletion implicates a role for alphaT-catenin in susceptibility to autism spectrum disorder","volume":"6","author":"Bacchelli","year":"2014","journal-title":"J. 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