{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:02:35Z","timestamp":1790650955048,"version":"4.1.0"},"reference-count":77,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["F32HL156644"],"award-info":[{"award-number":["F32HL156644"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35GM142950"],"award-info":[{"award-number":["R35GM142950"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adult humans respond to heart injury by forming a permanent scar, yet other vertebrates are capable of robust and complete cardiac regeneration. Despite progress towards characterizing the mechanisms of cardiac regeneration in fish and amphibians, the large evolutionary gulf between mammals and regenerating vertebrates complicates deciphering which cellular and molecular features truly enable regeneration. To better define these features, we compared cardiac injury responses in zebrafish and medaka, two fish species that share similar heart anatomy and common teleost ancestry but differ in regenerative capability. We used single-cell transcriptional profiling to create a time-resolved comparative cell atlas of injury responses in all major cardiac cell types across both species. With this approach, we identified several key features that distinguish cardiac injury response in the non-regenerating medaka heart. By comparing immune responses to injury, we found altered cell recruitment and a distinct pro-inflammatory gene program in medaka leukocytes, and an absence of the injury-induced interferon response seen in zebrafish. In addition, we found a lack of pro-regenerative signals, including nrg1 and retinoic acid, from medaka endothelial and epicardial cells. Finally, we identified alterations in the myocardial structure in medaka, where they lack primordial layer cardiomyocytes and fail to employ a cardioprotective gene program shared by regenerating vertebrates. Our findings reveal notable variation in injury response across nearly all major cardiac cell types in zebrafish and medaka, demonstrating how evolutionary divergence influences the hidden cellular features underpinning regenerative potential in these seemingly similar vertebrates.<\/jats:p>","DOI":"10.1242\/bio.060156","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T09:24:28Z","timestamp":1711358668000},"source":"Crossref","is-referenced-by-count":19,"title":["Distinct features of the regenerating heart uncovered through comparative single-cell profiling"],"prefix":"10.1242","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9458-649X","authenticated-orcid":false,"given":"Clayton M.","family":"Carey","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Utah 1 , Salt Lake City, UT, 84112 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7942-175X","authenticated-orcid":false,"given":"Hailey L.","family":"Hollins","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Utah 1 , Salt Lake City, UT, 84112 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2918-5748","authenticated-orcid":false,"given":"Alexis V.","family":"Schmid","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Utah 1 , Salt Lake City, UT, 84112 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3978-6058","authenticated-orcid":false,"given":"James A.","family":"Gagnon","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Utah 1 , Salt Lake City, UT, 84112 , USA"},{"name":"Henry Eyring Center for Cell & Genome Science, University of Utah 2 , Salt Lake City, UT 84112 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"2024040510440323500_BIO060156C1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.stem.2014.06.009","article-title":"Immune modulation of stem cells and regeneration","volume":"15","author":"Aurora","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2024040510440323500_BIO060156C2","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1093\/cvr\/cvz221","article-title":"Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish","volume":"116","author":"Bevan","year":"2020","journal-title":"Cardiovasc. 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