{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:03:20Z","timestamp":1753884200351,"version":"3.41.2"},"reference-count":85,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Mellowes Center for Genomic Science and Precision Medicine","award":["RRID:SCR_022926"],"award-info":[{"award-number":["RRID:SCR_022926"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NIH R01HL134932"],"award-info":[{"award-number":["NIH R01HL134932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008980","name":"Medical College of Wisconsin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008980","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder affecting 1:3500 male births and is associated with myofiber degeneration, regeneration, and inflammation. Glucocorticoid treatments have been the standard of care due to immunomodulatory\/immunosuppressive properties but novel genetic approaches, including exon skipping and gene replacement therapy, are currently being developed. The identification of additional biomarkers to assess DMD-related inflammatory responses and the potential efficacy of these therapeutic approaches are thus of critical importance. The current study uses RNA sequencing of skeletal muscle from two mdx mouse models to identify high mobility group box\u00a01 (HMGB1) as a candidate biomarker potentially contributing to DMD-related inflammation. HMGB1 protein content was increased in a human iPSC-derived skeletal myocyte model of DMD and microdystrophin treatment decreased HMGB1 back to control levels. In vivo, HMGB1 protein levels were increased in vehicle treated B10-mdx skeletal muscle compared to B10-WT and significantly decreased in B10-mdx animals treated with adeno-associated virus (AAV)-microdystrophin. However, HMGB1 protein levels were not increased in D2-mdx skeletal muscle compared to D2-WT, demonstrating a strain-specific difference in DMD-related immunopathology.<\/jats:p>","DOI":"10.1242\/bio.060542","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T13:30:41Z","timestamp":1724074241000},"source":"Crossref","is-referenced-by-count":0,"title":["High mobility group box\u00a01 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy"],"prefix":"10.1242","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-2522","authenticated-orcid":false,"given":"Rebecca A.","family":"Slick","sequence":"first","affiliation":[{"name":"Medical College of Wisconsin 1 Division of Pediatric Pathology, Department of Pathology and Laboratory Medicine and Neuroscience Research Center , , Milwaukee, WI 53226 ,","place":["USA"]},{"name":"Medical College of Wisconsin 2 Department of Physiology , , Milwaukee, WI 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,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-1993","authenticated-orcid":false,"given":"Mark A.","family":"Vanden Avond","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin 2 Department of Physiology , , Milwaukee, WI 53226 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3017-4517","authenticated-orcid":false,"given":"Emily","family":"Siebers","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin 1 Division of Pediatric Pathology, Department of Pathology and Laboratory Medicine and Neuroscience Research Center , , Milwaukee, WI 53226 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-7056","authenticated-orcid":false,"given":"David L.","family":"Mack","sequence":"additional","affiliation":[{"name":"University of Washington 6 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