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However, the time to regenerate ear tissue varies from 20 to 90\u2005days and muscle regeneration is inconsistent. Some report that \u22653-years and 9-week-old older spiny mice have delayed regeneration compared to 2-month and 3-week-old mice, respectively, without investigation on the regenerative capacity of muscle. We thought that delayed regeneration and inconsistent muscle regeneration could be linked via age-related nerve degeneration. While the current study found that spiny mice aged 6\u20139\u2005months had delayed regeneration compared to 3\u20134\u2005month-old spiny mice, the capacity of muscle regeneration was unrelated to age, and there was little evidence for age-related nerve degeneration. Instead, the regeneration of muscle, cartilage and adipocytes was spatially heterogeneous, regardless of age, declining in amount from the proximal to distal region of the regenerated tissue. Also, cartilage regeneration in the distal region was decreased in \u226522-month-old Acomys and adipocyte regeneration was decreased in those older than 6\u2005months, compared to 3\u20134 month olds. While the underlying mechanisms for delayed and spatially heterogenous regeneration remain unclear, age and the spatial region of the regenerated tissue should be considered in experimental designs with spiny mice.<\/jats:p>","DOI":"10.1242\/bio.060565","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:45:24Z","timestamp":1728560724000},"source":"Crossref","is-referenced-by-count":5,"title":["Older 6-9-month-old spiny mice (<i>Acomys cahirinus<\/i>) have delayed and spatially heterogenous ear wound regeneration"],"prefix":"10.1242","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2822-9045","authenticated-orcid":false,"given":"Justin A.","family":"Varholick","sequence":"first","affiliation":[{"name":"University of Florida 1 Department of Biology , , Gainesville, FL ,","place":["USA"]},{"name":"University of Florida 2 Department of Molecular Genetics and Microbiology , , Gainesville, FL ,","place":["USA"]},{"name":"McKnight Brain Institute, College of Medicine, University of Florida 3 , Gainesville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jazmine","family":"Thermolice","sequence":"additional","affiliation":[{"name":"University of Florida 4 Department of Psychology , , Gainesville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gizelle","family":"Godinez","sequence":"additional","affiliation":[{"name":"University of Florida 4 Department of Psychology , , Gainesville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"University of Florida 1 Department of Biology , , Gainesville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi","family":"Kondapaneni","sequence":"additional","affiliation":[{"name":"University of Florida 1 Department of Biology , , Gainesville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7178-5309","authenticated-orcid":false,"given":"Malcolm","family":"Maden","sequence":"additional","affiliation":[{"name":"University of Florida 1 Department of Biology , , Gainesville, FL ,","place":["USA"]},{"name":"McKnight Brain Institute, College of Medicine, University of Florida 3 , Gainesville, FL ,","place":["USA"]},{"name":"Genetics Institute, University of Florida 5 , Gainesville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"2025031115404376600_BIO060565C1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.08.06.552195","article-title":"Neural crest cells give rise to non-myogenic mesenchymal tissue in the adult murid ear pinna","author":"Allen","year":"2023","journal-title":"bioRxivorg"},{"key":"2025031115404376600_BIO060565C2","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1172\/JCI0215704","article-title":"Androgen receptor-mediated inhibition of cutaneous wound healing","volume":"110","author":"Ashcroft","year":"2002","journal-title":"J. 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