{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:20:02Z","timestamp":1780539602205,"version":"3.54.1"},"reference-count":108,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Friedrich-Alexander-Universitat Erlangen-Nurnberg - Campus Nurnberg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Sox8 is a transcription factor that belongs to the Sox family of high-mobility-group domain containing proteins and is closely related to Sox9 and Sox10. During prenatal development, Sox8 is expressed in several ectoderm-, endoderm- and mesoderm-derived tissues and has been implicated in processes of organogenesis and differentiation. Sox8 expression is found in several important cells such as Sertoli cells in the male gonad, glial cells, satellite cells, and chondrocytes. However, Sox8 is not essential for the proper development of any of the involved systems, as it functions redundantly with Sox9 or Sox10 and no major developmental disturbances have been noticed in its absence. Despite its perceived limited importance as a developmental regulator, Sox8 exhibits a more significant role in late development and adult tissues. Several studies highlight the importance of Sox8 for the homeostasis of adipose tissue, Sertoli cells and the blood-testis-barrier functioning, and the maintenance of myelin in the central nervous system. Emerging evidence points to SOX8 as a promising candidate for a disease-causing gene in humans and suggests that changes in SOX8 function or expression could contribute to pathological states. For instance, genetic variants of SOX8 have been linked to multiple sclerosis and familial essential tremor, while SOX8 alterations have been related to poor cancer prognosis and infertility. This Review provides an overview of Sox8's versatile role in development and adult tissues as well as its lesser-known contributions to various diseases, and its potential as a therapeutic target.<\/jats:p>","DOI":"10.1242\/bio.061840","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T12:01:51Z","timestamp":1739361711000},"source":"Crossref","is-referenced-by-count":12,"title":["Sox8: a multifaceted transcription factor in development and disease"],"prefix":"10.1242","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-7821","authenticated-orcid":false,"given":"Mar\u00eda Nazareth","family":"Gonz\u00e1lez Alvarado","sequence":"first","affiliation":[{"name":"Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC) 1 , 1030, Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-5591","authenticated-orcid":false,"given":"Jessica","family":"Aprato","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universit\u00e4t (FAU) Erlangen-N\u00fcrnberg 2 , 91054 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"2025021708475218100_BIO061840C1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ydbio.2013.12.011","article-title":"Identification of Pax3 and Zic1 targets in the developing neural crest","volume":"386","author":"Bae","year":"2014","journal-title":"Dev. Biol."},{"key":"2025021708475218100_BIO061840C2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.ydbio.2008.12.011","article-title":"Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8","volume":"327","author":"Barrionuevo","year":"2009","journal-title":"Dev. Biol."},{"key":"2025021708475218100_BIO061840C3","doi-asserted-by":"publisher","first-page":"e15635","DOI":"10.7554\/eLife.15635","article-title":"Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration","volume":"5","author":"Barrionuevo","year":"2016","journal-title":"eLife"},{"key":"2025021708475218100_BIO061840C4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0925-4773(00)00296-3","article-title":"SOX8 expression during chick embryogenesis","volume":"94","author":"Bell","year":"2000","journal-title":"Mech. Dev."},{"key":"2025021708475218100_BIO061840C5","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1093\/hmg\/ddg182","article-title":"Dimerization of SOX9 is required for chondrogenesis, but not for sex determination","volume":"12","author":"Bernard","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"2025021708475218100_BIO061840C6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1006\/dbio.2000.9883","article-title":"Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators","volume":"227","author":"Bowles","year":"2000","journal-title":"Dev. Biol."},{"key":"2025021708475218100_BIO061840C7","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1093\/nar\/gkg230","article-title":"Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements","volume":"31","author":"Bridgewater","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2025021708475218100_BIO061840C8","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1242\/dev.01087","article-title":"Functional analysis of Sox8 and Sox9 during sex determination in the mouse","volume":"131","author":"Chaboissier","year":"2004","journal-title":"Development"},{"key":"2025021708475218100_BIO061840C9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.2147\/CMAR.S187151","article-title":"Transcriptomic analyses identify key differentially expressed genes and clinical outcomes between triple-negative and non-triple-negative breast cancer","volume":"11","author":"Chen","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"2025021708475218100_BIO061840C10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0169-328X(01)00147-4","article-title":"Sox8 gene expression identifies immature glial cells in developing cerebellum and cerebellar tumours","volume":"92","author":"Cheng","year":"2001","journal-title":"Mol. Brain Res."},{"key":"2025021708475218100_BIO061840C11","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0012-1606(03)00066-6","article-title":"Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: sox genes and BMP signaling","volume":"257","author":"Chimal-Monroy","year":"2003","journal-title":"Dev. Biol."},{"key":"2025021708475218100_BIO061840C12","doi-asserted-by":"publisher","first-page":"104290","DOI":"10.1016\/j.ebiom.2022.104290","article-title":"Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology","volume":"85","author":"Clark","year":"2022","journal-title":"eBioMedicine"},{"key":"2025021708475218100_BIO061840C13","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1093\/nar\/22.16.3339","article-title":"DNA binding and bending properties of the postmeiotically expressed Sry-related protein Sox-5","volume":"22","author":"Connor","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"2025021708475218100_BIO061840C14","doi-asserted-by":"publisher","first-page":"100828","DOI":"10.1016\/j.bbrep.2020.100828","article-title":"The transcription factors SF-1 and SOX8 cooperate to upregulate Cx43 expression in mouse TM4 sertoli cells","volume":"24","author":"Couture","year":"2020","journal-title":"Biochem. Biophys. Rep."},{"key":"2025021708475218100_BIO061840C15","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1523\/JNEUROSCI.3145-15.2016","article-title":"Lhx2 is an essential factor for retinal Gliogenesis and Notch signaling","volume":"36","author":"De Melo","year":"2016","journal-title":"J. Neurosci."},{"key":"2025021708475218100_BIO061840C16","doi-asserted-by":"publisher","first-page":"32757","DOI":"10.1038\/srep32757","article-title":"Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis","volume":"6","author":"De Melo","year":"2016","journal-title":"Sci. Rep."},{"key":"2025021708475218100_BIO061840C17","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/(SICI)1097-0177(200003)217:3&lt;293::AID-DVDY7&gt;3.0.CO;2-P","article-title":"Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development","volume":"217","author":"de Santa Barbara","year":"2000","journal-title":"Dev. Dyn."},{"key":"2025021708475218100_BIO061840C18","doi-asserted-by":"publisher","first-page":"e2760918","DOI":"10.1155\/2018\/2760918","article-title":"Identification of key genes and pathways in triple-negative breast cancer by integrated bioinformatics analysis","volume":"2018","author":"Dong","year":"2018","journal-title":"BioMed. Res. Int."},{"key":"2025021708475218100_BIO061840C19","doi-asserted-by":"publisher","first-page":"9417","DOI":"10.2147\/CMAR.S268378","article-title":"MicroRNA-139 suppresses the tumorigenicity of triple negative breast cancer cells by targeting SOX8","volume":"12","author":"Dong","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"2025021708475218100_BIO061840C20","doi-asserted-by":"publisher","first-page":"e9235837","DOI":"10.1155\/2022\/9235837","article-title":"SOX8 knockdown overcomes enzalutamide resistance in castration-resistant prostate cancer by inhibiting the Notch signaling pathway","volume":"2022","author":"Du","year":"2022","journal-title":"BioMed. Res. Int."},{"key":"2025021708475218100_BIO061840C21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000321957","article-title":"A case of Agonadism, skeletal malformations, bicuspid aortic valve, and delayed development with a 16p13.3 duplication including GNG13 and SOX8 upstream enhancers: are either, both or neither involved in the phenotype?","volume":"1","author":"Erickson","year":"2011","journal-title":"Mol. Syndromol."},{"key":"2025021708475218100_BIO061840C22","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.1002\/j.1460-2075.1992.tb05551.x","article-title":"SRY, like HMG1, recognizes sharp angles in DNA","volume":"11","author":"Ferrari","year":"1992","journal-title":"EMBO J."},{"key":"2025021708475218100_BIO061840C23","doi-asserted-by":"publisher","first-page":"22272","DOI":"10.1038\/s41598-023-49476-5","article-title":"Endogenous Sox8 is a critical factor for timely remyelination and oligodendroglial cell repletion in the cuprizone model","volume":"13","author":"Freudenstein","year":"2023","journal-title":"Sci. Rep."},{"key":"2025021708475218100_BIO061840C24","doi-asserted-by":"publisher","first-page":"11199","DOI":"10.1073\/pnas.172383099","article-title":"A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination","volume":"99","author":"Gasca","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021708475218100_BIO061840C25","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1095\/biolreprod.112.101907","article-title":"Sox9 and Sox8 are required for basal lamina integrity of testis cords and for suppression of FOXL2 during embryonic testis development in mice","volume":"87","author":"Georg","year":"2012","journal-title":"Biol. Reprod."},{"key":"2025021708475218100_BIO061840C26","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1002\/mrd.23049","article-title":"Gja1 expression is regulated by cooperation between SOX8\/SOX9 and cJUN transcription factors in TM4 and 15P-1 Sertoli cell lines","volume":"85","author":"Ghouili","year":"2018","journal-title":"Mol. Reprod. Dev."},{"key":"2025021708475218100_BIO061840C27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/ajmg.a.32056","article-title":"Phenotype\u2013genotype characterization of alpha-thalassemia mental retardation syndrome due to isolated monosomy of 16p13.3","volume":"146A","author":"Gibson","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"key":"2025021708475218100_BIO061840C28","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.1007\/s00018-008-8138-7","article-title":"Having it both ways: Sox protein function between conservation and innovation","volume":"65","author":"Guth","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"2025021708475218100_BIO061840C29","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1194\/jlr.M800531-JLR200","article-title":"Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor","volume":"50","author":"Guth","year":"2009","journal-title":"J. Lipid Res."},{"key":"2025021708475218100_BIO061840C30","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1093\/nar\/22.8.1500","article-title":"Definition of a consensus DNA binding site for SRY","volume":"22","author":"Harley","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"2025021708475218100_BIO061840C31","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.1093\/nar\/gkz523","article-title":"The SOXE transcription factors\u2014SOX8, SOX9 and SOX10\u2014share a bi-partite transactivation mechanism","volume":"47","author":"Haseeb","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2025021708475218100_BIO061840C32","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.1073\/pnas.95.9.5161","article-title":"Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease","volume":"95","author":"Herbarth","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021708475218100_BIO061840C33","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1002\/stem.1642","article-title":"Brief report: importance of SOX8 for in vitro chondrogenic differentiation of human mesenchymal stromal cells","volume":"32","author":"Herlofsen","year":"2014","journal-title":"Stem Cells"},{"key":"2025021708475218100_BIO061840C34","doi-asserted-by":"publisher","first-page":"e1003907","DOI":"10.1371\/journal.pgen.1003907","article-title":"The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes","volume":"9","author":"Hornig","year":"2013","journal-title":"PLoS Genet."},{"key":"2025021708475218100_BIO061840C35","doi-asserted-by":"publisher","first-page":"10398","DOI":"10.1038\/srep10398","article-title":"SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains","volume":"5","author":"Huang","year":"2015","journal-title":"Sci. Rep."},{"key":"2025021708475218100_BIO061840C36","doi-asserted-by":"publisher","first-page":"e7014567","DOI":"10.1155\/2024\/7014567","article-title":"Molecular characterization, phylogeny, and expression profiles of soxe subfamily in Scophthalmus maximus","volume":"2024","author":"Ji","year":"2024","journal-title":"J. Appl. Ichthyol."},{"key":"2025021708475218100_BIO061840C37","doi-asserted-by":"publisher","first-page":"6444","DOI":"10.21037\/tcr-20-492","article-title":"Identification and validation of potential novel prognostic biomarkers for patients with glioma based on a gene co-expression network","volume":"9","author":"Jiang","year":"2020","journal-title":"Transl. Cancer Res."},{"key":"2025021708475218100_BIO061840C38","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.1002\/cne.23351","article-title":"Characterization of the trunk neural crest in the bamboo shark, Chiloscyllium punctatum","volume":"521","author":"Juarez","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"2025021708475218100_BIO061840C39","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1242\/dev.091793","article-title":"Sox proteins: regulators of cell fate specification and differentiation","volume":"140","author":"Kamachi","year":"2013","journal-title":"Development"},{"key":"2025021708475218100_BIO061840C40","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1387\/ijdb.150192ao","article-title":"Expression of Sox genes in tooth development","volume":"59","author":"Kawasaki","year":"2015","journal-title":"Int. J. Dev. Biol."},{"key":"2025021708475218100_BIO061840C41","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1242\/dev.02477","article-title":"Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence","volume":"133","author":"Kellerer","year":"2006","journal-title":"Development"},{"key":"2025021708475218100_BIO061840C42","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1196\/annals.1411.007","article-title":"Sox8 and sertoli-cell function","volume":"1120","author":"Kennedy","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025021708475218100_BIO061840C43","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1084\/jem.20181604","article-title":"Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice","volume":"216","author":"Kimura","year":"2019","journal-title":"J. Exp. Med."},{"key":"2025021708475218100_BIO061840C44","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nature06617","article-title":"The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans","volume":"451","author":"King","year":"2008","journal-title":"Nature"},{"key":"2025021708475218100_BIO061840C45","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/351117a0","article-title":"Male development of chromosomally female mice transgenic for Sry","volume":"351","author":"Koopman","year":"1991","journal-title":"Nature"},{"key":"2025021708475218100_BIO061840C46","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.devbrainres.2005.03.009","article-title":"Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse","volume":"157","author":"Kordes","year":"2005","journal-title":"Dev. Brain Res."},{"key":"2025021708475218100_BIO061840C47","doi-asserted-by":"publisher","first-page":"e1003170","DOI":"10.1371\/journal.pgen.1003170","article-title":"Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals","volume":"8","author":"Lavery","year":"2012","journal-title":"PLoS Genet."},{"key":"2025021708475218100_BIO061840C48","doi-asserted-by":"publisher","first-page":"e22586","DOI":"10.1016\/j.heliyon.2023.e22586","article-title":"SOX8 promotes tumor growth and metastasis through FZD6-dependent Wnt\/\u03b2-catenin signaling in colorectal carcinoma","volume":"9","author":"Li","year":"2023","journal-title":"Heliyon"},{"key":"2025021708475218100_BIO061840C49","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1093\/brain\/awt101","article-title":"MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis","volume":"136","author":"Lill","year":"2013","journal-title":"Brain"},{"key":"2025021708475218100_BIO061840C50","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/jpm13010032","article-title":"Whole-exome sequencing identifies genetic variants for severe adolescent idiopathic scoliosis in a Taiwanese population","volume":"13","author":"Lin","year":"2023","journal-title":"J. Pers. Med."},{"key":"2025021708475218100_BIO061840C51","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/dvdy.10311","article-title":"Expression of Sox transcription factors in the developing mouse pancreas","volume":"227","author":"Lioubinski","year":"2003","journal-title":"Dev. Dyn."},{"key":"2025021708475218100_BIO061840C52","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.cbpb.2012.05.004","article-title":"Homologues of sox8 and sox10 in the orange-spotted grouper Epinephelus coioides: sequences, expression patterns, and their effects on cyp19a1a promoter activities in vitro","volume":"163","author":"Liu","year":"2012","journal-title":"Comp. Biochem. Physiol. Part B Biochem. Mol. Biol."},{"key":"2025021708475218100_BIO061840C53","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.3892\/etm.2019.7349","article-title":"Investigation of transcriptome mechanism associated with osteoporosis explored by microarray analysis","volume":"17","author":"Liu","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"2025021708475218100_BIO061840C54","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.trsl.2021.10.002","article-title":"differential expression of members of SOX family of transcription factors in failing human hearts","volume":"242","author":"Liu","year":"2022","journal-title":"Transl. Res."},{"key":"2025021708475218100_BIO061840C55","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ydbio.2004.09.014","article-title":"Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect","volume":"277","author":"Maka","year":"2005","journal-title":"Dev. Biol."},{"key":"2025021708475218100_BIO061840C56","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/nature04691","article-title":"Importance of SoxE in neural crest development and the evolution of the pharynx","volume":"441","author":"McCauley","year":"2006","journal-title":"Nature"},{"key":"2025021708475218100_BIO061840C57","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.mcn.2011.12.008","article-title":"Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina","volume":"49","author":"McNeill","year":"2012","journal-title":"Mol. Cell. Neurosci."},{"key":"2025021708475218100_BIO061840C58","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1002\/cne.24232","article-title":"Selective neuronal expression of the SoxE factor, Sox8, in direct pathway striatal projection neurons of the developing mouse brain","volume":"525","author":"Merchan-Sala","year":"2017","journal-title":"J. Comp. Neurol."},{"key":"2025021708475218100_BIO061840C59","doi-asserted-by":"publisher","first-page":"e2316969121","DOI":"10.1073\/pnas.2316969121","article-title":"Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation","volume":"121","author":"Molin","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021708475218100_BIO061840C60","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.exer.2009.05.006","article-title":"The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for M\u00fcller glial cell development in mouse retina","volume":"89","author":"Muto","year":"2009","journal-title":"Exp. Eye Res."},{"key":"2025021708475218100_BIO061840C61","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1095\/biolreprod.115.131276","article-title":"Gonadal identity in the absence of pro-testis factor SOX9 and pro-ovary factor beta-catenin in mice","volume":"93","author":"Nicol","year":"2015","journal-title":"Biol. Reprod."},{"key":"2025021708475218100_BIO061840C62","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1262\/jrd.2015-092","article-title":"Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene","volume":"62","author":"Nishimura","year":"2016","journal-title":"J. Reprod. Dev."},{"key":"2025021708475218100_BIO061840C63","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.ydbio.2008.01.042","article-title":"Sox8 is a critical regulator of adult Sertoli cell function and male fertility","volume":"316","author":"O'Bryan","year":"2008","journal-title":"Dev. Biol."},{"key":"2025021708475218100_BIO061840C64","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1242\/dev.02558","article-title":"Functional analysis of Sox8 during neural crest development in Xenopus","volume":"133","author":"O'Donnell","year":"2006","journal-title":"Development"},{"key":"2025021708475218100_BIO061840C65","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1093\/nar\/28.16.3047","article-title":"The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences","volume":"28","author":"Peirano","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2025021708475218100_BIO061840C66","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1006\/geno.1999.6060","article-title":"The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome","volume":"63","author":"Pfeifer","year":"2000","journal-title":"Genomics"},{"key":"2025021708475218100_BIO061840C67","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s00280-021-04378-z","article-title":"SOX8 promotes cetuximab resistance via HGF\/MET bypass pathway activation in colorectal cancer","volume":"89","author":"Piao","year":"2022","journal-title":"Cancer Chemother. Pharmacol."},{"key":"2025021708475218100_BIO061840C68","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1093\/hmg\/ddy037","article-title":"Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies","volume":"27","author":"Portnoi","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"2025021708475218100_BIO061840C69","doi-asserted-by":"publisher","first-page":"21795","DOI":"10.1073\/pnas.1016485107","article-title":"Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression","volume":"107","author":"Pozniak","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021708475218100_BIO061840C70","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1093\/hmg\/ddq558","article-title":"SOX9 controls epithelial branching by activating RET effector genes during kidney development","volume":"20","author":"Reginensi","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"2025021708475218100_BIO061840C71","doi-asserted-by":"publisher","first-page":"e53972","DOI":"10.7554\/eLife.53972","article-title":"Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals","volume":"9","author":"Richardson","year":"2020","journal-title":"eLife"},{"key":"2025021708475218100_BIO061840C72","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12958-022-01045-7","article-title":"Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development","volume":"21","author":"Rjiba","year":"2023","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2025021708475218100_BIO061840C73","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.bbrc.2019.03.096","article-title":"Transcriptomic analysis of overexpressed SOX4 and SOX8 in TM4 Sertoli cells with emphasis on cell-to-cell interactions","volume":"512","author":"Roumaud","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025021708475218100_BIO061840C74","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10143-007-0087-3","article-title":"Increased expression of ephrin A1 in brain arteriovenous malformation: DNA microarray analysis","volume":"30","author":"Sasahara","year":"2007","journal-title":"Neurosurg. Rev."},{"key":"2025021708475218100_BIO061840C75","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature10251","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","volume":"476","author":"Sawcer","year":"2011","journal-title":"Nature"},{"key":"2025021708475218100_BIO061840C76","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1093\/nar\/28.6.1473","article-title":"Cloning and characterisation of the Sry-related transcription factor gene Sox8","volume":"28","author":"Schepers","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2025021708475218100_BIO061840C77","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000056956","article-title":"Mouse Sox8 is located between, not within, the t-complex deletions tw18 and th20 on chromosome 17","volume":"93","author":"Schepers","year":"2001","journal-title":"Cytogenet. Cell Genet."},{"key":"2025021708475218100_BIO061840C78","doi-asserted-by":"publisher","first-page":"28101","DOI":"10.1074\/jbc.M304067200","article-title":"SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro","volume":"278","author":"Schepers","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025021708475218100_BIO061840C79","doi-asserted-by":"publisher","first-page":"5509","DOI":"10.1093\/nar\/gkf690","article-title":"Cooperative binding of Sox10 to DNA: requirements and consequences","volume":"30","author":"Schlierf","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2025021708475218100_BIO061840C80","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/j.1365-2990.2007.00881.x","article-title":"Expression of SoxE and SoxD genes in human gliomas","volume":"33","author":"Schlierf","year":"2007","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"2025021708475218100_BIO061840C81","doi-asserted-by":"publisher","first-page":"29769","DOI":"10.1074\/jbc.M301539200","article-title":"Sox8 is a specific marker for muscle satellite cells and inhibits Myogenesis","volume":"278","author":"Schmidt","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025021708475218100_BIO061840C82","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1083\/jcb.200408013","article-title":"The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation","volume":"168","author":"Schmidt","year":"2005","journal-title":"J. Cell Biol."},{"key":"2025021708475218100_BIO061840C83","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1242\/dev.003350","article-title":"Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages","volume":"134","author":"Schreiner","year":"2007","journal-title":"Development"},{"key":"2025021708475218100_BIO061840C84","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1210\/mend.16.3.0782","article-title":"Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins","volume":"16","author":"Shen","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"2025021708475218100_BIO061840C85","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/346240a0","article-title":"A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif","volume":"346","author":"Sinclair","year":"1990","journal-title":"Nature"},{"key":"2025021708475218100_BIO061840C86","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000200078","article-title":"Downstream genes of Sox8 that would affect adult male fertility","volume":"3","author":"Singh","year":"2009","journal-title":"Sex Dev."},{"key":"2025021708475218100_BIO061840C87","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1095\/biolreprod.112.107284","article-title":"SOX8 regulates permeability of the blood-testes barrier that affects adult male fertility in the mouse","volume":"88","author":"Singh","year":"2013","journal-title":"Biol. Reprod."},{"key":"2025021708475218100_BIO061840C88","doi-asserted-by":"publisher","first-page":"6951","DOI":"10.1128\/MCB.21.20.6951-6959.2001","article-title":"Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8","volume":"21","author":"Sock","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2025021708475218100_BIO061840C89","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1093\/hmg\/ddg158","article-title":"Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia","volume":"12","author":"Sock","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"2025021708475218100_BIO061840C90","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1101\/gad.259003","article-title":"The Sox9 transcription factor determines glial fate choice in the developing spinal cord","volume":"17","author":"Stolt","year":"2003","journal-title":"Genes Dev."},{"key":"2025021708475218100_BIO061840C91","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1242\/dev.01114","article-title":"Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy","volume":"131","author":"Stolt","year":"2004","journal-title":"Development"},{"key":"2025021708475218100_BIO061840C92","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ydbio.2005.03.010","article-title":"Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord","volume":"281","author":"Stolt","year":"2005","journal-title":"Dev. Biol."},{"key":"2025021708475218100_BIO061840C93","doi-asserted-by":"publisher","first-page":"27848","DOI":"10.1074\/jbc.272.44.27848","article-title":"Two independent nuclear localization signals are present in the DNA-binding high-mobility group domains of SRY and SOX9","volume":"272","author":"S\u00fcdbeck","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2025021708475218100_BIO061840C94","doi-asserted-by":"publisher","first-page":"6928","DOI":"10.7150\/thno.43811","article-title":"Aurora-A\/SOX8\/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"key":"2025021708475218100_BIO061840C95","doi-asserted-by":"publisher","first-page":"e00749","DOI":"10.1002\/prp2.749","article-title":"SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem\/precursor cells downstream of Nfia","volume":"9","author":"Takouda","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"key":"2025021708475218100_BIO061840C96","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1093\/carcin\/bgz034","article-title":"SOX8 acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer","volume":"40","author":"Tang","year":"2019","journal-title":"Carcinogenesis"},{"key":"2025021708475218100_BIO061840C97","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1080\/15384047.2020.1840318","article-title":"The oncogenic role of SOX8 in endometrial carcinoma","volume":"21","author":"Tian","year":"2020","journal-title":"Cancer Biol. Ther."},{"key":"2025021708475218100_BIO061840C98","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/glia.23242","article-title":"Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes","volume":"66","author":"Turnescu","year":"2018","journal-title":"Glia"},{"key":"2025021708475218100_BIO061840C99","doi-asserted-by":"publisher","first-page":"e16237","DOI":"10.1097\/MD.0000000000016237","article-title":"Over-expression of SOX8 predicts poor prognosis in colorectal cancer","volume":"98","author":"Wang","year":"2019","journal-title":"Medicine (Baltim.)"},{"key":"2025021708475218100_BIO061840C100","doi-asserted-by":"publisher","first-page":"e200088","DOI":"10.1212\/NXG.0000000000200088","article-title":"Biallelic SOX8 variants associated with novel syndrome with myopathy, skeletal deformities, intellectual disability, and ovarian dysfunction","volume":"9","author":"Warman-Chardon","year":"2023","journal-title":"Neurol. Genet."},{"key":"2025021708475218100_BIO061840C101","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.semcdb.2016.08.013","article-title":"SoxE factors: transcriptional regulators of neural differentiation and nervous system development","volume":"63","author":"Weider","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"2025021708475218100_BIO061840C102","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ng.3097","article-title":"Defining the role of common variation in the genomic and biological architecture of adult human height","volume":"46","author":"Wood","year":"2014","journal-title":"Nat. Genet."},{"key":"2025021708475218100_BIO061840C103","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s12041-010-0024-z","article-title":"cDNA cloning and expression analysis of two distinct Sox8 genes in Paramisgurnus dabryanus (Cypriniformes)","volume":"89","author":"Xia","year":"2010","journal-title":"J. Genet."},{"key":"2025021708475218100_BIO061840C104","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10528-010-9396-2","article-title":"Isolation and expression of two distinct Sox8 genes in mudloach (Misgurnus anguillicaudatus)","volume":"49","author":"Xia","year":"2011","journal-title":"Biochem. Genet."},{"key":"2025021708475218100_BIO061840C105","first-page":"6534","article-title":"miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer","volume":"7","author":"Xie","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"2025021708475218100_BIO061840C106","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/ijc.31134","article-title":"SOX8 regulates cancer stem-like properties and cisplatin-induced EMT in tongue squamous cell carcinoma by acting on the Wnt\/\u03b2-catenin pathway","volume":"142","author":"Xie","year":"2018","journal-title":"Int. J. Cancer"},{"key":"2025021708475218100_BIO061840C107","doi-asserted-by":"publisher","first-page":"103002","DOI":"10.1016\/j.redox.2023.103002","article-title":"Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis","volume":"69","author":"Yang","year":"2023","journal-title":"Redox. Biol."},{"key":"2025021708475218100_BIO061840C108","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1007\/s12032-014-0918-3","article-title":"Oncogenicity of the transcription factor SOX8 in hepatocellular carcinoma","volume":"31","author":"Zhang","year":"2014","journal-title":"Med. Oncol."}],"container-title":["Biology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.061840\/3618540\/bio061840.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.061840\/3618540\/bio061840.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T08:48:07Z","timestamp":1739782087000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/bio\/article\/14\/2\/bio061840\/365654\/Sox8-a-multifaceted-transcription-factor-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":108,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,15]]}},"URL":"https:\/\/doi.org\/10.1242\/bio.061840","relation":{},"ISSN":["2046-6390"],"issn-type":[{"value":"2046-6390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,12]]},"article-number":"bio061840"}}