{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:47:28Z","timestamp":1758044848351,"version":"3.44.0"},"reference-count":26,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100002028","name":"Collins Medical Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002028","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American Speech-Language Hearing Foundation New Investigators Research Grant"},{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Voice deficits are common in Parkinson's disease (PD) and significantly impact quality of life by increasing stress, social isolation, and caregiver burden. However, despite this impact, there are currently no treatments that target the underlying pathophysiology of PD in the vocalization system. The goal of this study was to examine the effect of one possible underlying mechanism responsible for the complex voice deficits that exist in PD; overexpression of the protein alpha-synuclein. Results show that overexpression of alpha-synuclein, prior to the development of alpha-synuclein aggregate pathology, does not result in significant vocalization deficits. A small but statistically significant increase in the total number of complex vocalizations was found in mice overexpressing alpha-synuclein compared to wild-type mice, but there were no differences in complexity ratio or any of the other specific vocalization parameters tested. Results provide a critical foundational understanding of the impact of overexpression versus aggregation of alpha-synuclein on voice deficits in PD. Future work will focus on manipulation of alpha-synuclein aggregate pathology, and not overexpression alone, to reduce or eliminate the burden of PD specific voice disorders.<\/jats:p>","DOI":"10.1242\/bio.062120","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T12:15:28Z","timestamp":1755260128000},"source":"Crossref","is-referenced-by-count":0,"title":["Alpha-synuclein overexpression does not cause vocalization deficits in a mouse model of parkinsonism"],"prefix":"10.1242","volume":"14","author":[{"given":"Brooke","family":"Rodgers","sequence":"first","affiliation":[{"name":"Purdue University Department of Speech, Language, and Hearing Sciences , , West Lafayette, IN 47907 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-0565","authenticated-orcid":false,"given":"Allison","family":"Schaser","sequence":"additional","affiliation":[{"name":"Purdue University Department of Speech, Language, and Hearing Sciences , , West Lafayette, IN 47907 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"2025091212260321400_BIO062120C1","doi-asserted-by":"publisher","first-page":"e46610","DOI":"10.1371\/journal.pone.0046610","article-title":"Of mice, birds, and men: the mouse ultrasonic song system has some features similar to humans and song-learning birds","volume":"7","author":"Arriaga","year":"2012","journal-title":"PLoS ONE"},{"key":"2025091212260321400_BIO062120C2","doi-asserted-by":"publisher","first-page":"54137","DOI":"10.3791\/54137","article-title":"Eliciting and analyzing male mouse ultrasonic vocalization (USV) songs","volume":"123","author":"Chabout","year":"2017","journal-title":"J. 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