{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T11:01:35Z","timestamp":1772017295103,"version":"3.50.1"},"reference-count":113,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Down syndrome (DS) is caused by trisomy for human chromosome 21 (Hsa21) and is associated with atypical neurodevelopment that begins prenatally. The developing human fetus receives nutritional support and gas exchange from the placenta, and normal placental function is essential for proper development. Placentas that sustain fetuses with trisomy 21 contain trisomic cells, but little is known about which Hsa21 genes are overexpressed in the placenta or their downstream molecular, cellular, and functional effects. Although access to human placentas is limited, mouse models of DS provide excellent in vivo systems for investigating the prenatal effects of trisomy. This study examined the placental transcriptome in four mouse models of DS: Dp(16)1\/Yey, Ts65Dn, Ts66Yah, and Ts1Cje. Placental gene and protein expression analyses showed that trisomy increased the expression of App, Sod1, and Ifnar1 in Dp(16)1\/Yey, Ts65Dn, and Ts66Yah; APP and SOD1 in Dp(16)1\/Yey and Ts66Yah; and IFNAR1 in Ts66Yah. Despite modest overlap of trisomy-associated gene dysregulation among these four models, altered extracellular matrix pathways in all four models and upregulation of immune system pathways in Dp(16)1\/Yey and Ts66Yah were identified. Altered redox homeostasis was observed for all four models, with Ts1Cje showing distinct changes in SOD activity and antioxidant capacity in comparison to the other three models. Immunofluorescence staining revealed region-specific upregulation of APP, SOD1, and IFNAR1 in Ts66Yah trisomic placentas. This work provides a foundation for understanding the effects of trisomy for Hsa21 orthologs on the mouse placenta and on prenatal development.<\/jats:p>","DOI":"10.1242\/bio.062296","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T10:49:57Z","timestamp":1764845397000},"source":"Crossref","is-referenced-by-count":0,"title":["The placental effects of trisomy for human chromosome 21 orthologs in four mouse models of Down syndrome"],"prefix":"10.1242","volume":"14","author":[{"given":"Taisuke","family":"Sato","sequence":"first","affiliation":[{"name":"Center for Precision Health Research 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]},{"name":"National Human Genome Research Institute, National Institutes of Health 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-1088","authenticated-orcid":false,"given":"Laura L.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Center for Precision Health Research 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]},{"name":"National Human Genome Research Institute, National Institutes of Health 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"April D.","family":"Adams","sequence":"additional","affiliation":[{"name":"Center for Precision Health Research 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]},{"name":"National Human Genome Research Institute, National Institutes of Health 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]},{"name":"Baylor College of Medicine 2 Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine , , Houston, TX 77030 ,","place":["USA"]},{"name":"Baylor College of Medicine 3 Department of Molecular and Human Genetics , , Houston, TX 77030 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren A.","family":"Bishop","sequence":"additional","affiliation":[{"name":"Center for Precision Health Research 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]},{"name":"National Human Genome Research Institute, National Institutes of Health 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]},{"name":"Columbia University Irving Medical Center 4 , Division of Reproductive Endocrinology and Infertility, New York, NY 10019 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8847-1119","authenticated-orcid":false,"given":"Faycal","family":"Guedj","sequence":"additional","affiliation":[{"name":"Center for Precision Health Research 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]},{"name":"National Human Genome Research Institute, National Institutes of Health 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-5267","authenticated-orcid":false,"given":"Diana W.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Center for Precision Health Research 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]},{"name":"National Human Genome Research Institute, National Institutes of Health 1 , Prenatal Genomics and Therapy Section , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"2026022504583256500_BIO062296C1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S1097-2765(05)00014-6","article-title":"Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development","volume":"6","author":"Adams","year":"2000","journal-title":"Mol. Cell"},{"key":"2026022504583256500_BIO062296C2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.placenta.2019.10.002","article-title":"Placental development and function in trisomy 21 and mouse models of Down syndrome: Clues for studying mechanisms underlying atypical development","volume":"89","author":"Adams","year":"2020","journal-title":"Placenta"},{"key":"2026022504583256500_BIO062296C3","doi-asserted-by":"publisher","first-page":"296.e213","DOI":"10.1016\/j.ajog.2021.03.019","article-title":"Novel insights from fetal and placental phenotyping in 3 mouse models of Down syndrome","volume":"225","author":"Adams","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2026022504583256500_BIO062296C4","doi-asserted-by":"publisher","first-page":"258.e251","DOI":"10.1016\/j.ajog.2023.07.056","article-title":"Embryonic statistical analyses reveal 2 growth phenotypes in mouse models of Down syndrome","volume":"230","author":"Adams","year":"2024","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2026022504583256500_BIO062296C5","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.3109\/14767058.2013.768982","article-title":"Senescence in amniocytes and placentas from trisomy 21 pregnancies","volume":"26","author":"Amiel","year":"2013","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"key":"2026022504583256500_BIO062296C6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41572-019-0143-7","article-title":"Down syndrome","volume":"6","author":"Antonarakis","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2026022504583256500_BIO062296C7","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking placental development in health and disease","volume":"16","author":"Aplin","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"2026022504583256500_BIO062296C8","doi-asserted-by":"publisher","first-page":"111883","DOI":"10.1016\/j.celrep.2022.111883","article-title":"IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome","volume":"41","author":"Araya","year":"2022","journal-title":"Cell Rep."},{"key":"2026022504583256500_BIO062296C9","doi-asserted-by":"publisher","first-page":"dmm031013","DOI":"10.1242\/dmm.031013","article-title":"Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1\/Yey mouse models of Down syndrome","volume":"11","author":"Aziz","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"2026022504583256500_BIO062296C10","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/dmcn.14260","article-title":"New approaches to studying early brain development in Down syndrome","volume":"61","author":"Baburamani","year":"2019","journal-title":"Dev. Med. Child Neurol."},{"key":"2026022504583256500_BIO062296C11","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/S0002-9378(12)80029-9","article-title":"Fetuses with Down syndrome have disproportionately shortened frontal lobe dimensions on ultrasonographic examination","volume":"167","author":"Bahado-Singh","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2026022504583256500_BIO062296C12","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S1097-2765(00)80209-9","article-title":"PPAR gamma is required for placental, cardiac, and adipose tissue development","volume":"4","author":"Barak","year":"1999","journal-title":"Mol. Cell"},{"key":"2026022504583256500_BIO062296C13","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.freeradbiomed.2017.07.009","article-title":"Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism","volume":"114","author":"Barone","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"2026022504583256500_BIO062296C14","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1002\/pd.4862","article-title":"Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects","volume":"36","author":"Bianco","year":"2016","journal-title":"Prenat. Diagn."},{"key":"2026022504583256500_BIO062296C15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \u201cGreat Obstetrical Syndromes\u201d are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2026022504583256500_BIO062296C16","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1126\/science.aaw7733","article-title":"IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise","volume":"365","author":"Buchrieser","year":"2019","journal-title":"Science"},{"key":"2026022504583256500_BIO062296C17","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.3390\/jcm10112382","article-title":"Prenatal screening of trisomy 21: could oxidative stress markers play a role?","volume":"10","author":"Buczy\u0144ska","year":"2021","journal-title":"J. Clin. Med."},{"key":"2026022504583256500_BIO062296C18","doi-asserted-by":"publisher","first-page":"245ra92","DOI":"10.1126\/scitranslmed.3008808","article-title":"Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia","volume":"6","author":"Buhimschi","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"2026022504583256500_BIO062296C19","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"key":"2026022504583256500_BIO062296C20","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/378776a0","article-title":"Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro","volume":"378","author":"Busciglio","year":"1995","journal-title":"Nature"},{"key":"2026022504583256500_BIO062296C21","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S1471-4914(01)02173-6","article-title":"Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide","volume":"7","author":"Butterfield","year":"2001","journal-title":"Trends Mol. Med."},{"key":"2026022504583256500_BIO062296C22","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1083\/jcb.107.6.2169","article-title":"Molecular immunocytochemistry of the CuZn superoxide dismutase in rat hepatocytes","volume":"107","author":"Chang","year":"1988","journal-title":"J. Cell Biol."},{"key":"2026022504583256500_BIO062296C23","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/aji.12446","article-title":"Understanding pre-eclampsia using Alzheimer's etiology: an intriguing viewpoint","volume":"75","author":"Cheng","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"2026022504583256500_BIO062296C24","doi-asserted-by":"publisher","first-page":"107012","DOI":"10.1016\/j.isci.2023.107012","article-title":"Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling","volume":"26","author":"Chi","year":"2023","journal-title":"iScience"},{"key":"2026022504583256500_BIO062296C25","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/hipo.20308","article-title":"Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice","volume":"17","author":"Contestabile","year":"2007","journal-title":"Hippocampus"},{"key":"2026022504583256500_BIO062296C26","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.4103\/1673-5374.257511","article-title":"Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved","volume":"14","author":"Coronel","year":"2019","journal-title":"Neural Regen. Res."},{"key":"2026022504583256500_BIO062296C27","doi-asserted-by":"publisher","first-page":"10405","DOI":"10.1073\/pnas.89.21.10405","article-title":"Copper, zinc superoxide dismutase is primarily a cytosolic protein in human cells","volume":"89","author":"Crapo","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026022504583256500_BIO062296C28","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1242\/dmm.007716","article-title":"The use of mouse models to understand and improve cognitive deficits in Down syndrome","volume":"4","author":"Das","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"2026022504583256500_BIO062296C29","first-page":"263","article-title":"Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome","volume":"360","author":"Davisson","year":"1990","journal-title":"Prog. Clin. Biol. Res."},{"key":"2026022504583256500_BIO062296C30","doi-asserted-by":"publisher","first-page":"107147","DOI":"10.1016\/j.isci.2023.107147","article-title":"IFITM1 inhibits trophoblast invasion and is induced in placentas associated with IFN-mediated pregnancy diseases","volume":"26","author":"Degrelle","year":"2023","journal-title":"iScience"},{"key":"2026022504583256500_BIO062296C31","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1161\/CIRCULATIONAHA.122.059706","article-title":"Cardiovascular complications of Down syndrome: scoping review and expert consensus","volume":"147","author":"Dimopoulos","year":"2023","journal-title":"Circulation"},{"key":"2026022504583256500_BIO062296C32","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1007\/s00335-011-9356-0","article-title":"Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome","volume":"22","author":"Duchon","year":"2011","journal-title":"Mamm. Genome"},{"key":"2026022504583256500_BIO062296C33","doi-asserted-by":"publisher","first-page":"dmm049721","DOI":"10.1242\/dmm.049721","article-title":"Ts66Yah, a mouse model of Down syndrome with improved construct and face validity","volume":"15","author":"Duchon","year":"2022","journal-title":"Dis. Model. Mech."},{"key":"2026022504583256500_BIO062296C34","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1182\/blood-2011-09-380709","article-title":"CLEC-2 and Syk in the megakaryocytic\/platelet lineage are essential for development","volume":"119","author":"Finney","year":"2012","journal-title":"Blood"},{"key":"2026022504583256500_BIO062296C35","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1210\/jc.85.10.3700","article-title":"Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down's syndrome","volume":"85","author":"Frendo","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026022504583256500_BIO062296C36","doi-asserted-by":"publisher","first-page":"3638","DOI":"10.1210\/endo.142.8.8329","article-title":"Overexpression of copper zinc superoxide dismutase impairs human trophoblast cell fusion and differentiation","volume":"142","author":"Frendo","year":"2001","journal-title":"Endocrinology"},{"key":"2026022504583256500_BIO062296C37","doi-asserted-by":"publisher","first-page":"eadg6218","DOI":"10.1126\/sciadv.adg6218","article-title":"Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition","volume":"9","author":"Galbraith","year":"2023","journal-title":"Sci. Adv."},{"key":"2026022504583256500_BIO062296C38","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1523\/JNEUROSCI.2513-15.2016","article-title":"Absence of prenatal forebrain defects in the Dp(16)1Yey\/+ mouse model of Down syndrome","volume":"36","author":"Goodliffe","year":"2016","journal-title":"J. Neurosci."},{"key":"2026022504583256500_BIO062296C39","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/pd.4134","article-title":"Noninvasive prenatal testing creates an opportunity for antenatal treatment of Down syndrome","volume":"33","author":"Guedj","year":"2013","journal-title":"Prenat. Diagn."},{"key":"2026022504583256500_BIO062296C40","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.biopsych.2023.02.012","article-title":"The impact of Mmu17 non-Hsa21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the gold standard refuted","volume":"94","author":"Guedj","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"2026022504583256500_BIO062296C41","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/j.1750-3639.2007.00113.x","article-title":"Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome","volume":"18","author":"Guidi","year":"2008","journal-title":"Brain Pathol."},{"key":"2026022504583256500_BIO062296C42","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1750-3639.2010.00459.x","article-title":"Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome","volume":"21","author":"Guidi","year":"2011","journal-title":"Brain Pathol."},{"key":"2026022504583256500_BIO062296C43","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1111\/bpa.12605","article-title":"Abnormal development of the inferior temporal region in fetuses with Down syndrome","volume":"28","author":"Guidi","year":"2018","journal-title":"Brain Pathol."},{"key":"2026022504583256500_BIO062296C44","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1203\/01.pdr.0000190580.88391.9a","article-title":"Biometry of face and brain in fetuses with trisomy 21","volume":"59","author":"Guihard-Costa","year":"2006","journal-title":"Pediatr. Res."},{"key":"2026022504583256500_BIO062296C45","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1007\/s00335-016-9661-8","article-title":"Mouse models of Down syndrome: gene content and consequences","volume":"27","author":"Gupta","year":"2016","journal-title":"Mamm. Genome"},{"key":"2026022504583256500_BIO062296C46","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/00019052-200404000-00003","article-title":"Down syndrome and beta-amyloid deposition","volume":"17","author":"Head","year":"2004","journal-title":"Curr. Opin. Neurol."},{"key":"2026022504583256500_BIO062296C47","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1242\/dmm.029728","article-title":"Rodent models in Down syndrome research: impact and future opportunities","volume":"10","author":"Herault","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"2026022504583256500_BIO062296C48","doi-asserted-by":"publisher","first-page":"7765","DOI":"10.1074\/jbc.273.13.7765","article-title":"Reduced fertility in female mice lacking copper-zinc superoxide dismutase","volume":"273","author":"Ho","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2026022504583256500_BIO062296C49","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1006\/abbi.1997.0237","article-title":"Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts","volume":"344","author":"Huang","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"2026022504583256500_BIO062296C50","doi-asserted-by":"publisher","first-page":"F1000 Faculty Rev-389","DOI":"10.12688\/f1000research.7506.1","article-title":"The importance of understanding individual differences in Down syndrome","volume":"5","author":"Karmiloff-Smith","year":"2016","journal-title":"F1000Res"},{"key":"2026022504583256500_BIO062296C51","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/pd.3826","article-title":"Expression of transcription factors controlling alpha inhibin gene expression in placental tissues from pregnancies affected by fetal Down syndrome","volume":"32","author":"Kipp","year":"2012","journal-title":"Prenat. Diagn."},{"key":"2026022504583256500_BIO062296C52","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1002\/pd.6436","article-title":"Biometric magnetic resonance imaging analysis of fetal brain development in Down syndrome","volume":"43","author":"Kitano","year":"2023","journal-title":"Prenat. Diagn."},{"key":"2026022504583256500_BIO062296C53","doi-asserted-by":"publisher","first-page":"941855","DOI":"10.3389\/fncel.2022.941855","article-title":"Neurodevelopment in Down syndrome: concordance in humans and models","volume":"16","author":"Klein","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"2026022504583256500_BIO062296C54","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.aanat.2008.05.007","article-title":"Reduced cell number in the neocortical part of the human fetal brain in Down syndrome","volume":"190","author":"Larsen","year":"2008","journal-title":"Ann. Anat."},{"key":"2026022504583256500_BIO062296C55","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1046\/j.1471-4159.2001.00107.x","article-title":"Effect of overexpression of wild-type and mutant Cu\/Zn-superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis","volume":"76","author":"Lee","year":"2001","journal-title":"J. Neurochem."},{"key":"2026022504583256500_BIO062296C56","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.molmed.2019.10.001","article-title":"Challenges and opportunities for translation of therapies to improve cognition in Down syndrome","volume":"26","author":"Lee","year":"2020","journal-title":"Trends Mol. Med."},{"key":"2026022504583256500_BIO062296C57","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/hmg\/ddae160","article-title":"Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cells","volume":"34","author":"Lee","year":"2025","journal-title":"Hum. Mol. Genet."},{"key":"2026022504583256500_BIO062296C58","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1093\/hmg\/ddm086","article-title":"Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities","volume":"16","author":"Li","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"2026022504583256500_BIO062296C59","doi-asserted-by":"publisher","first-page":"521","DOI":"10.2174\/156720506779025305","article-title":"Beta-amyloid, oxidative stress and down syndrome","volume":"3","author":"Lott","year":"2006","journal-title":"Curr. Alzheimer Res."},{"key":"2026022504583256500_BIO062296C60","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1182\/blood-2014-09-603803","article-title":"Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development","volume":"125","author":"Lowe","year":"2015","journal-title":"Blood"},{"key":"2026022504583256500_BIO062296C61","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1093\/hmg\/dds052","article-title":"OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors","volume":"21","author":"Lu","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"2026022504583256500_BIO062296C62","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.coi.2021.06.006","article-title":"Down syndrome and type I interferon: not so simple","volume":"72","author":"Malle","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"2026022504583256500_BIO062296C63","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1172\/JCI29959","article-title":"Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood","volume":"117","author":"Maron","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2026022504583256500_BIO062296C64","doi-asserted-by":"publisher","first-page":"e60266","DOI":"10.7554\/eLife.60266","article-title":"Single nuclei RNA-seq of mouse placental labyrinth development","volume":"9","author":"Marsh","year":"2020","journal-title":"eLife"},{"key":"2026022504583256500_BIO062296C65","doi-asserted-by":"publisher","first-page":"1341141","DOI":"10.3389\/fncel.2024.1341141","article-title":"Transcriptional consequences of trisomy 21 on neural induction","volume":"18","author":"Martinez","year":"2024","journal-title":"Front. Cell Neurosci."},{"key":"2026022504583256500_BIO062296C66","doi-asserted-by":"publisher","first-page":"20999","DOI":"10.1038\/srep20999","article-title":"Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development","volume":"6","author":"Maruyama","year":"2016","journal-title":"Sci. Rep."},{"key":"2026022504583256500_BIO062296C67","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1242\/dmm.011957","article-title":"Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice","volume":"6","author":"Mohun","year":"2013","journal-title":"Dis. Model. Mech."},{"key":"2026022504583256500_BIO062296C68","doi-asserted-by":"publisher","first-page":"824922","DOI":"10.3389\/fgene.2022.824922","article-title":"Overexpression of the Hsa21 transcription factor RUNX1 modulates the extracellular matrix in trisomy 21 cells","volume":"13","author":"Mollo","year":"2022","journal-title":"Front. Genet."},{"key":"2026022504583256500_BIO062296C69","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00335-007-9030-8","article-title":"The power of comparative and developmental studies for mouse models of Down syndrome","volume":"18","author":"Moore","year":"2007","journal-title":"Mamm. Genome"},{"key":"2026022504583256500_BIO062296C70","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00418-004-0677-x","article-title":"Oxidative stress in the placenta","volume":"122","author":"Myatt","year":"2004","journal-title":"Histochem. Cell Biol."},{"key":"2026022504583256500_BIO062296C71","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1160\/TH13-01-0060","article-title":"The physiological and pathophysiological roles of platelet CLEC-2","volume":"109","author":"Navarro-N\u00fa\u00f1ez","year":"2013","journal-title":"Thromb. Haemost."},{"key":"2026022504583256500_BIO062296C72","doi-asserted-by":"publisher","first-page":"38388","DOI":"10.1074\/jbc.M105395200","article-title":"Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria","volume":"276","author":"Okado-Matsumoto","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2026022504583256500_BIO062296C73","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/dvdy.20079","article-title":"Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje\/Ts65Dn exhibit variable severity of cerebellar phenotypes","volume":"230","author":"Olson","year":"2004","journal-title":"Dev. Dyn."},{"key":"2026022504583256500_BIO062296C74","doi-asserted-by":"publisher","first-page":"102139","DOI":"10.1016\/j.nicl.2019.102139","article-title":"Early alterations in cortical and cerebellar regional brain growth in Down syndrome: an in vivo fetal and neonatal MRI assessment","volume":"25","author":"Patkee","year":"2020","journal-title":"Neuroimage Clin."},{"key":"2026022504583256500_BIO062296C75","doi-asserted-by":"publisher","first-page":"e18866","DOI":"10.1371\/journal.pone.0018866","article-title":"Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening","volume":"6","author":"Pennings","year":"2011","journal-title":"PLoS ONE"},{"key":"2026022504583256500_BIO062296C76","doi-asserted-by":"publisher","first-page":"724904","DOI":"10.1155\/2012\/724904","article-title":"Oxidative stress and Down syndrome: a route toward Alzheimer-like dementia","volume":"2012","author":"Perluigi","year":"2012","journal-title":"Curr. Gerontol. Geriatr. Res."},{"key":"2026022504583256500_BIO062296C77","doi-asserted-by":"publisher","first-page":"S79","DOI":"10.1016\/j.placenta.2004.01.007","article-title":"Impact of trisomy 21 on human trophoblast behaviour and hormonal function","volume":"25","author":"Pidoux","year":"2004","journal-title":"Placenta"},{"key":"2026022504583256500_BIO062296C78","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1159\/000264470","article-title":"Trisomy 21 placentas: histopathological and immunohistochemical findings using proliferating cell nuclear antigen","volume":"12","author":"Qureshi","year":"1997","journal-title":"Fetal Diagn. Ther."},{"key":"2026022504583256500_BIO062296C79","doi-asserted-by":"publisher","first-page":"RP99323","DOI":"10.7554\/eLife.99323","article-title":"JAK inhibition decreases the autoimmune burden in Down syndrome","volume":"13","author":"Rachubinski","year":"2024","journal-title":"eLife"},{"key":"2026022504583256500_BIO062296C80","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/s41467-023-36740-5","article-title":"Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease","volume":"14","author":"Radford","year":"2023","journal-title":"Nat. Commun."},{"key":"2026022504583256500_BIO062296C81","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/ng1095-177","article-title":"A mouse model for Down syndrome exhibits learning and behaviour deficits","volume":"11","author":"Reeves","year":"1995","journal-title":"Nat. Genet."},{"key":"2026022504583256500_BIO062296C82","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1053\/plac.2000.0553","article-title":"Histomorphological features of chorionic villi at 10-14 weeks of gestation in trisomic and chromosomally normal pregnancies","volume":"21","author":"Roberts","year":"2000","journal-title":"Placenta"},{"key":"2026022504583256500_BIO062296C83","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S0029-7844(97)00076-8","article-title":"Fetal transcerebellar diameter in Down syndrome","volume":"89","author":"Rotmensch","year":"1997","journal-title":"Obstet. Gynecol."},{"key":"2026022504583256500_BIO062296C84","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1093\/humrep\/dem214","article-title":"Genome-wide expression analysis of cultured trophoblast with trisomy 21 karyotype","volume":"22","author":"Rozovski","year":"2007","journal-title":"Hum. Reprod."},{"key":"2026022504583256500_BIO062296C85","doi-asserted-by":"publisher","first-page":"6256","DOI":"10.1073\/pnas.95.11.6256","article-title":"Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities","volume":"95","author":"Sago","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026022504583256500_BIO062296C86","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/1471-2164-9-352","article-title":"Spatial and temporal expression of the 23 murine Prolactin\/Placental Lactogen-related genes is not associated with their position in the locus","volume":"9","author":"Simmons","year":"2008","journal-title":"BMC Genomics"},{"key":"2026022504583256500_BIO062296C87","doi-asserted-by":"publisher","first-page":"9425","DOI":"10.1073\/pnas.0903909106","article-title":"Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses","volume":"106","author":"Slonim","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026022504583256500_BIO062296C88","doi-asserted-by":"publisher","first-page":"903729","DOI":"10.3389\/fncel.2022.903729","article-title":"The challenging pathway of treatment for neurogenesis impairment in Down syndrome: achievements and perspectives","volume":"16","author":"Stagni","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"2026022504583256500_BIO062296C89","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2017.07.026","article-title":"Neurogenesis impairment: an early developmental defect in Down syndrome","volume":"114","author":"Stagni","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"2026022504583256500_BIO062296C90","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/bpa.12663","article-title":"Subicular hypotrophy in fetuses with Down syndrome and in the Ts65Dn model of Down syndrome","volume":"29","author":"Stagni","year":"2019","journal-title":"Brain Pathol."},{"key":"2026022504583256500_BIO062296C91","doi-asserted-by":"publisher","first-page":"105870","DOI":"10.1016\/j.clineuro.2020.105870","article-title":"Neuroanatomical alterations in higher-order thalamic nuclei of fetuses with Down syndrome","volume":"194","author":"Stagni","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"2026022504583256500_BIO062296C92","doi-asserted-by":"publisher","first-page":"e2301","DOI":"10.1002\/bdr2.2301","article-title":"National population-based estimates for major birth defects, 2016-2020","volume":"116","author":"Stallings","year":"2024","journal-title":"Birth Defects Res."},{"key":"2026022504583256500_BIO062296C93","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1002\/ajmg.a.36594","article-title":"Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice","volume":"164A","author":"Starbuck","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"key":"2026022504583256500_BIO062296C94","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/ajmg.1320370715","article-title":"Epidemiology of Down syndrome in 118,265 consecutive births","volume":"37","author":"Stoll","year":"1990","journal-title":"Am. J. Med. Genet. Suppl."},{"key":"2026022504583256500_BIO062296C95","doi-asserted-by":"publisher","first-page":"e16220","DOI":"10.7554\/eLife.16220","article-title":"Trisomy 21 consistently activates the interferon response","volume":"5","author":"Sullivan","year":"2016","journal-title":"eLife"},{"key":"2026022504583256500_BIO062296C96","doi-asserted-by":"publisher","first-page":"14818","DOI":"10.1038\/s41598-017-13858-3","article-title":"Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation","volume":"7","author":"Sullivan","year":"2017","journal-title":"Sci. Rep."},{"key":"2026022504583256500_BIO062296C97","first-page":"3738","article-title":"Proteomic analysis of the alteration of protein expression in the placenta of Down syndrome","volume":"124","author":"Sun","year":"2011","journal-title":"Chin. Med. J."},{"key":"2026022504583256500_BIO062296C98","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1093\/cercor\/bhz094","article-title":"Quantitative MRI Analyses of Regional Brain Growth in Living Fetuses with Down Syndrome","volume":"30","author":"Tarui","year":"2020","journal-title":"Cereb. Cortex"},{"key":"2026022504583256500_BIO062296C99","doi-asserted-by":"publisher","first-page":"103638","DOI":"10.1016\/j.ridd.2020.103638","article-title":"A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment","volume":"104","author":"Thomas","year":"2020","journal-title":"Res. Dev. Disabil."},{"key":"2026022504583256500_BIO062296C100","doi-asserted-by":"publisher","first-page":"eabj5445","DOI":"10.1126\/sciadv.abj5445","article-title":"Adhesion G protein-coupled receptor Gpr126\/Adgrg6 is essential for placental development","volume":"7","author":"Torregrosa-Carrion","year":"2021","journal-title":"Sci. Adv."},{"key":"2026022504583256500_BIO062296C101","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s00335-021-09930-z","article-title":"Mouse models of aneuploidy to understand chromosome disorders","volume":"33","author":"Tosh","year":"2022","journal-title":"Mamm. Genome"},{"key":"2026022504583256500_BIO062296C102","doi-asserted-by":"publisher","first-page":"108407","DOI":"10.1016\/j.celrep.2020.108407","article-title":"JAK1 inhibition blocks lethal immune hypersensitivity in a mouse model of Down syndrome","volume":"33","author":"Tuttle","year":"2020","journal-title":"Cell Rep."},{"key":"2026022504583256500_BIO062296C103","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.devcel.2015.01.022","article-title":"Cellular functions of the amyloid precursor protein from development to dementia","volume":"32","author":"van der Kant","year":"2015","journal-title":"Dev. Cell"},{"key":"2026022504583256500_BIO062296C104","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/s41588-023-01399-7","article-title":"Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model","volume":"55","author":"Waugh","year":"2023","journal-title":"Nat. Genet."},{"key":"2026022504583256500_BIO062296C105","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nrn3983","article-title":"A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome","volume":"16","author":"Wiseman","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"2026022504583256500_BIO062296C106","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1056\/NEJM198411013111819","article-title":"Evidence of arrest of neurogenesis and synaptogenesis in brains of patients with Down's syndrome","volume":"311","author":"Wisniewski","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"2026022504583256500_BIO062296C107","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1016\/j.ajpath.2018.07.004","article-title":"Amyloid precursor protein overexpression in Down syndrome trophoblast reduces cell invasiveness and interferes with Syncytialization","volume":"188","author":"Wong","year":"2018","journal-title":"Am. J. Pathol."},{"key":"2026022504583256500_BIO062296C108","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3389\/fendo.2018.00570","article-title":"Regulation of placental development and its impact on fetal growth-new insights from mouse models","volume":"9","author":"Woods","year":"2018","journal-title":"Front. Endocrinol."},{"key":"2026022504583256500_BIO062296C109","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1093\/hmg\/ddad056","article-title":"Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome","volume":"32","author":"Xing","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"2026022504583256500_BIO062296C110","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1093\/cercor\/bhaa255","article-title":"Regional alterations in cortical sulcal depth in living fetuses with Down syndrome","volume":"31","author":"Yun","year":"2021","journal-title":"Cereb. Cortex"},{"key":"2026022504583256500_BIO062296C111","doi-asserted-by":"publisher","first-page":"19844","DOI":"10.1074\/jbc.AC119.010611","article-title":"Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins","volume":"294","author":"Zani","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2026022504583256500_BIO062296C112","doi-asserted-by":"publisher","first-page":"84489","DOI":"10.18632\/oncotarget.21060","article-title":"Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"2026022504583256500_BIO062296C113","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Biology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.062296\/3675680\/bio062296.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.062296\/3677309\/bio062296.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.062296\/3677309\/bio062296.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:58:43Z","timestamp":1772013523000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/bio\/article\/14\/12\/bio062296\/370141\/The-placental-effects-of-trisomy-for-human"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":113,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.1242\/bio.062296","relation":{},"ISSN":["2046-6390"],"issn-type":[{"value":"2046-6390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"article-number":"bio062296"}}