{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T11:05:29Z","timestamp":1767351929154,"version":"3.48.0"},"reference-count":114,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"crossref","award":["RR150106"],"award-info":[{"award-number":["RR150106"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001368","name":"V Foundation for Cancer Research","doi-asserted-by":"crossref","award":["V2017-017"],"award-info":[{"award-number":["V2017-017"]}],"id":[{"id":"10.13039\/100001368","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Child Health and Human Development","award":["R01HD099252"],"award-info":[{"award-number":["R01HD099252"]}]},{"name":"National Institute of Child Health and Human Development","award":["R01HD098131"],"award-info":[{"award-number":["R01HD098131"]}]},{"name":"NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Disruptions in pancreatic development can lead to health issues such as pancreatic agenesis and congenital diabetes mellitus. Understanding pancreatic organogenesis is critical for elucidating disease mechanisms and developing regenerative therapies. The pancreas consists of endocrine and exocrine cells, both of which are derived from multipotent progenitor cells (MPCs). MPC proliferation and differentiation are tightly controlled by multiple mechanisms, including post-transcriptional regulation by miRNAs. However, these regulatory factors are not fully understood. Here, we profiled miRNA expression in MPCs and identified that mir-302 was highly enriched during the earliest stages of pancreatic development. Loss of mir-302 resulted in reduced pancreatic size without altering the proportions of endocrine and exocrine cells at E17.5, suggesting that mir-302 regulates the number of MPCs rather than their differentiation. Transcriptomic analysis at E10.5 revealed that mir-302 modulates genes associated with the Wnt signaling pathway and cell cycle progression. Notably, loss of mir-302 prolonged the S phase in MPCs, resulting in slower cell proliferation and a smaller MPC pool at E10.5. These findings provide the first comprehensive miRNA profile during early pancreatic development and establish mir-302 as a critical regulator of MPC number and pancreas size.<\/jats:p>","DOI":"10.1242\/bio.062353","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:44:42Z","timestamp":1765536282000},"source":"Crossref","is-referenced-by-count":0,"title":["miR-302 regulates pancreatic progenitor pool and pancreatic size"],"prefix":"10.1242","volume":"15","author":[{"given":"Ziyue Z.","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Cell and Gene Therapy, Stem Cells and Regenerative Medicine Center 1 , Department of Neuroscience, Department of Molecular and Cellular Biology, Translational Biology and Molecular Medicine Program , , One Baylor Plaza, Houston, TX 77030 ,","place":["USA"]},{"name":"Baylor College of Medicine 1 , Department of Neuroscience, Department of Molecular and Cellular Biology, Translational Biology and Molecular Medicine Program , , One Baylor Plaza, Houston, TX 77030 ,","place":["USA"]},{"name":"Baylor College of Medicine 2 Development, Disease Models and Therapeutics Graduate Department , , One Baylor Plaza, Houston, TX 77030 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline G.","family":"Snider","sequence":"additional","affiliation":[{"name":"Rice University 3 Department of BioSciences , , Houston, TX 77005 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-2806","authenticated-orcid":false,"given":"Ronald J.","family":"Parchem","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Stem Cells and Regenerative Medicine Center 1 , Department of Neuroscience, Department of Molecular and Cellular Biology, Translational Biology and Molecular Medicine Program , , One Baylor Plaza, Houston, TX 77030 ,","place":["USA"]},{"name":"Baylor College of Medicine 1 , Department of Neuroscience, Department of Molecular and Cellular Biology, Translational Biology and Molecular Medicine Program , , One Baylor Plaza, Houston, TX 77030 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"author":"Agenesis of the dorsal pancreas - About the Disease - Genetic and Rare Diseases Information Center","key":"2026010206015564200_BIO062353C1"},{"key":"2026010206015564200_BIO062353C2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/ng.1035","article-title":"GATA6 haploinsufficiency causes pancreatic agenesis in humans","volume":"44","author":"Allen","year":"2011","journal-title":"Nat. Genet."},{"author":"Andrews","key":"2026010206015564200_BIO062353C3"},{"key":"2026010206015564200_BIO062353C4","doi-asserted-by":"publisher","first-page":"e1346","DOI":"10.1038\/cddis.2014.302","article-title":"FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt\/PCP pathway","volume":"5","author":"Asad","year":"2014","journal-title":"Cell Death Dis."},{"key":"2026010206015564200_BIO062353C5","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3390\/molecules23020282","article-title":"MiR200 and miR302: two big families influencing stem cell behavior","volume":"23","author":"Balzano","year":"2018","journal-title":"Molecules"},{"key":"2026010206015564200_BIO062353C6","doi-asserted-by":"publisher","first-page":"19575","DOI":"10.1074\/jbc.M611841200","article-title":"MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines","volume":"282","author":"Baroukh","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2026010206015564200_BIO062353C7","doi-asserted-by":"publisher","first-page":"6609","DOI":"10.1128\/MCB.00398-08","article-title":"Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter","volume":"28","author":"Barroso-DelJesus","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"2026010206015564200_BIO062353C8","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"2026010206015564200_BIO062353C9","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1172\/JCI87439","article-title":"Advances in \u03b2 cell replacement and regeneration strategies for treating diabetes","volume":"126","author":"Benthuysen","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2026010206015564200_BIO062353C10","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.molmed.2008.07.001","article-title":"let-7 microRNAs in development, stem cells and cancer","volume":"14","author":"B\u00fcssing","year":"2008","journal-title":"Trends Mol. Med."},{"key":"2026010206015564200_BIO062353C11","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1172\/JCI63240","article-title":"GATA4 and GATA6 control mouse pancreas organogenesis","volume":"122","author":"Carrasco","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2026010206015564200_BIO062353C12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cbd.2015.08.002","article-title":"Evolutionary conservation and function of the human embryonic stem cell specific miR-302\/367 cluster","volume":"16","author":"Chen","year":"2015","journal-title":"Comp. Biochem. Physiol. D Genomics Proteomics"},{"key":"2026010206015564200_BIO062353C13","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.devcel.2009.11.006","article-title":"Cell cycle control of wnt receptor activation","volume":"17","author":"Davidson","year":"2009","journal-title":"Dev. Cell"},{"key":"2026010206015564200_BIO062353C14","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1242\/dev.128.6.871","article-title":"A bipotential precursor population for pancreas and liver within the embryonic endoderm","volume":"128","author":"Deutsch","year":"2001","journal-title":"Development"},{"key":"2026010206015564200_BIO062353C15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2026010206015564200_BIO062353C16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/B978-0-12-820719-2.00012-0","article-title":"Micrornas in pancreas and islet development and function","volume-title":"Microrna in Regenerative Medicine","author":"Dom\u00ednguez-Bendala","year":"2023"},{"key":"2026010206015564200_BIO062353C17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1463-1326.2012.01656.x","article-title":"MicroRNAs in pancreas development","volume":"14","author":"Dumortier","year":"2012","journal-title":"Diabetes Obes. Metab."},{"key":"2026010206015564200_BIO062353C18","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.2337\/db07-1614","article-title":"miR-375 targets 3\u2032-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells","volume":"57","author":"El Ouaamari","year":"2008","journal-title":"Diabetes"},{"key":"2026010206015564200_BIO062353C19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.mce.2017.02.043","article-title":"The small RNA miR-375 - a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function","volume":"456","author":"Eliasson","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"2026010206015564200_BIO062353C20","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nrgastro.2017.93","article-title":"Regenerative medicine and cell-based approaches to restore pancreatic function","volume":"14","author":"Ellis","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2026010206015564200_BIO062353C21","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1101\/gad.233791.113","article-title":"miR-99a\/100\u223c125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGF\u03b2 and Wnt signaling","volume":"28","author":"Emmrich","year":"2014","journal-title":"Genes Dev."},{"key":"2026010206015564200_BIO062353C22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.gene.2015.08.027","article-title":"MicroRNA dynamics during human embryonic stem cell differentiation to pancreatic endoderm","volume":"574","author":"Fogel","year":"2015","journal-title":"Gene"},{"key":"2026010206015564200_BIO062353C23","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1159\/000090825","article-title":"Genomic imprinting in Dicer1-hypomorphic mice","volume":"113","author":"Fukasawa","year":"2006","journal-title":"Cytogenet. Genome Res."},{"key":"2026010206015564200_BIO062353C24","doi-asserted-by":"publisher","first-page":"150138","DOI":"10.1098\/rsob.150138","article-title":"The miR-302\/367 cluster: a comprehensive update on its evolution and functions","volume":"5","author":"Gao","year":"2015","journal-title":"Open Biol."},{"key":"2026010206015564200_BIO062353C25","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1182\/blood-2011-01-331686","article-title":"Genetic screen identifies microRNA cluster 99b\/let-7e\/125a as a regulator of primitive hematopoietic cells","volume":"119","author":"Gerrits","year":"2012","journal-title":"Blood"},{"key":"2026010206015564200_BIO062353C26","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1242\/dev.129.10.2447","article-title":"Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors","volume":"129","author":"Gu","year":"2002","journal-title":"Development"},{"key":"2026010206015564200_BIO062353C27","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/cr.2016.2","article-title":"Pluripotency-associated miR-290\/302 family of microRNAs promote the dismantling of naive pluripotency","volume":"26","author":"Gu","year":"2016","journal-title":"Cell Res."},{"key":"2026010206015564200_BIO062353C28","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.tcb.2022.05.006","article-title":"Wnt signalling in cell division: from mechanisms to tissue engineering","volume":"32","author":"Habib","year":"2022","journal-title":"Trends Cell Biol."},{"key":"2026010206015564200_BIO062353C29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0925-4773(02)00331-3","article-title":"Hedgehog signaling in pancreas development","volume":"120","author":"Hebrok","year":"2003","journal-title":"Mech. Dev."},{"key":"2026010206015564200_BIO062353C30","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1101\/gad.12.11.1705","article-title":"Notochord repression of endodermal Sonic hedgehog permits pancreas development","volume":"12","author":"Hebrok","year":"1998","journal-title":"Genes Dev."},{"key":"2026010206015564200_BIO062353C31","doi-asserted-by":"publisher","first-page":"4905","DOI":"10.1242\/dev.127.22.4905","article-title":"Regulation of pancreas development by hedgehog signaling","volume":"127","author":"Hebrok","year":"2000","journal-title":"Development"},{"key":"2026010206015564200_BIO062353C32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1113\/jphysiol.2002.036582","article-title":"Lifetime consequences of abnormal fetal pancreatic development","volume":"547","author":"Holemans","year":"2003","journal-title":"J. Physiol. (Lond)"},{"key":"2026010206015564200_BIO062353C33","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1007\/s13277-012-0446-8","article-title":"miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway","volume":"33","author":"Hu","year":"2012","journal-title":"Tumour Biol."},{"key":"2026010206015564200_BIO062353C34","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.ydbio.2007.09.008","article-title":"MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3","volume":"311","author":"Joglekar","year":"2007","journal-title":"Dev. Biol."},{"key":"2026010206015564200_BIO062353C35","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.gep.2008.10.001","article-title":"Expression of islet-specific microRNAs during human pancreatic development","volume":"9","author":"Joglekar","year":"2009","journal-title":"Gene Expr. Patterns"},{"key":"2026010206015564200_BIO062353C36","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1210\/er.2007-0016","article-title":"An illustrated review of early pancreas development in the mouse","volume":"28","author":"J\u00f8rgensen","year":"2007","journal-title":"Endocr. Rev."},{"key":"2026010206015564200_BIO062353C37","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.2337\/db12-0841","article-title":"Dicer1 is required to repress neuronal fate during endocrine cell maturation","volume":"62","author":"Kanji","year":"2013","journal-title":"Diabetes"},{"key":"2026010206015564200_BIO062353C38","doi-asserted-by":"publisher","DOI":"10.3791\/61086","article-title":"Preparation of small RNA libraries for sequencing from early mouse embryos","author":"Keuls","year":"2020","journal-title":"J. Vis. Exp."},{"key":"2026010206015564200_BIO062353C39","doi-asserted-by":"publisher","first-page":"7534","DOI":"10.3390\/ijms21207534","article-title":"MiR-302 regulates glycolysis to control cell-cycle during neural tube closure","volume":"21","author":"Keuls","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2026010206015564200_BIO062353C40","doi-asserted-by":"publisher","first-page":"e2212578120","DOI":"10.1073\/pnas.2212578120","article-title":"Post-transcriptional regulation in cranial neural crest cells expands developmental potential","volume":"120","author":"Keuls","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026010206015564200_BIO062353C41","doi-asserted-by":"publisher","first-page":"13036","DOI":"10.1073\/pnas.95.22.13036","article-title":"Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor","volume":"95","author":"Kim","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026010206015564200_BIO062353C42","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1872-034X.2010.00752.x","article-title":"Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation","volume":"41","author":"Kim","year":"2011","journal-title":"Hepatol. Res."},{"key":"2026010206015564200_BIO062353C43","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00125-012-2812-x","article-title":"miRNA-30a-5p-mediated silencing of Beta2\/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models","volume":"56","author":"Kim","year":"2013","journal-title":"Diabetologia"},{"key":"2026010206015564200_BIO062353C44","doi-asserted-by":"publisher","first-page":"e203","DOI":"10.1371\/journal.pbio.0050203","article-title":"Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development","volume":"5","author":"Kloosterman","year":"2007","journal-title":"PLoS Biol."},{"key":"2026010206015564200_BIO062353C45","doi-asserted-by":"publisher","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2026010206015564200_BIO062353C46","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1101\/gad.12.23.3752","article-title":"The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas","volume":"12","author":"Krapp","year":"1998","journal-title":"Genes Dev."},{"key":"2026010206015564200_BIO062353C47","doi-asserted-by":"publisher","first-page":"695214","DOI":"10.1155\/2012\/695214","article-title":"Regulation of pancreatic microRNA-7 expression","volume":"2012","author":"Kredo-Russo","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"2026010206015564200_BIO062353C48","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S0960-9822(02)00809-6","article-title":"Identification of tissue-specific microRNAs from mouse","volume":"12","author":"Lagos-Quintana","year":"2002","journal-title":"Curr. Biol."},{"key":"2026010206015564200_BIO062353C49","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1007\/s11033-014-3054-4","article-title":"MiRNA-375 promotes beta pancreatic differentiation in human induced pluripotent stem (hiPS) cells","volume":"41","author":"Lahmy","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"2026010206015564200_BIO062353C50","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1172\/JCI73066","article-title":"MicroRNA-7a regulates pancreatic \u03b2 cell function","volume":"124","author":"Latreille","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2026010206015564200_BIO062353C51","doi-asserted-by":"publisher","first-page":"e1003118","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"2026010206015564200_BIO062353C52","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1002\/stem.1302","article-title":"Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming","volume":"31","author":"Lee","year":"2013","journal-title":"Stem Cells"},{"key":"2026010206015564200_BIO062353C53","doi-asserted-by":"publisher","first-page":"e2078","DOI":"10.1038\/cddis.2015.383","article-title":"miR-302 regulates pluripotency, teratoma formation and differentiation in stem cells via an AKT1\/OCT4-dependent manner","volume":"7","author":"Li","year":"2016","journal-title":"Cell Death Dis."},{"key":"2026010206015564200_BIO062353C54","doi-asserted-by":"publisher","first-page":"4552","DOI":"10.1038\/s41598-020-61495-0","article-title":"COMPSRA: a COMprehensive platform for small RNA-seq data analysis","volume":"10","author":"Li","year":"2020","journal-title":"Sci. Rep."},{"key":"2026010206015564200_BIO062353C55","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1242\/jcs.123570","article-title":"Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions","volume":"126","author":"Liao","year":"2013","journal-title":"J. Cell Sci."},{"key":"2026010206015564200_BIO062353C56","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1093\/nar\/gkq850","article-title":"Regulation of somatic cell reprogramming through inducible mir-302 expression","volume":"39","author":"Lin","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2026010206015564200_BIO062353C57","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1101\/gad.17221311","article-title":"Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response","volume":"25","author":"Lipchina","year":"2011","journal-title":"Genes Dev."},{"key":"2026010206015564200_BIO062353C58","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.3892\/or.2014.3388","article-title":"Inhibition of Rac1 activity induces G1\/S phase arrest through the GSK3\/cyclin D1 pathway in human cancer cells","volume":"32","author":"Liu","year":"2014","journal-title":"Oncol. Rep."},{"key":"2026010206015564200_BIO062353C59","doi-asserted-by":"publisher","first-page":"6175","DOI":"10.18632\/oncotarget.6742","article-title":"FZD7 regulates BMSCs-mediated protection of CML cells","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"2026010206015564200_BIO062353C60","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/978-981-15-2389-2_3","article-title":"Animal models of pancreas development, developmental disorders, and disease","volume":"1236","author":"Lorberbaum","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"2026010206015564200_BIO062353C61","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2026010206015564200_BIO062353C62","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.2337\/db07-0175","article-title":"MicroRNA expression is required for pancreatic islet cell genesis in the mouse","volume":"56","author":"Lynn","year":"2007","journal-title":"Diabetes"},{"key":"2026010206015564200_BIO062353C63","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2026010206015564200_BIO062353C64","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1242\/dev.091751","article-title":"The neural crest","volume":"140","author":"Mayor","year":"2013","journal-title":"Development"},{"key":"2026010206015564200_BIO062353C65","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav1741","article-title":"The biochemical basis of microRNA targeting efficacy","volume":"366","author":"McGeary","year":"2019","journal-title":"Science"},{"key":"2026010206015564200_BIO062353C66","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3892\/ol.2015.3872","article-title":"MicroRNA-183-5p promotes the proliferation, invasion and metastasis of human pancreatic adenocarcinoma cells","volume":"11","author":"Miao","year":"2016","journal-title":"Oncol. Lett."},{"key":"2026010206015564200_BIO062353C67","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3390\/cells12040565","article-title":"Wnt pathway in pancreatic development and pathophysiology","volume":"12","author":"Napolitano","year":"2023","journal-title":"Cells"},{"key":"2026010206015564200_BIO062353C68","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1038\/emboj.2012.124","article-title":"Mitotic and mitogenic Wnt signalling","volume":"31","author":"Niehrs","year":"2012","journal-title":"EMBO J."},{"key":"2026010206015564200_BIO062353C69","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.3727\/096368911X612521","article-title":"Antisense miR-7 impairs insulin expression in developing pancreas and in cultured pancreatic buds","volume":"21","author":"Nieto","year":"2012","journal-title":"Cell Transplant."},{"key":"2026010206015564200_BIO062353C70","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/s41586-019-1127-1","article-title":"The emergent landscape of the mouse gut endoderm at single-cell resolution","volume":"569","author":"Nowotschin","year":"2019","journal-title":"Nature"},{"key":"2026010206015564200_BIO062353C71","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1242\/dev.122.3.983","article-title":"PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum","volume":"122","author":"Offield","year":"1996","journal-title":"Development"},{"key":"2026010206015564200_BIO062353C72","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.stem.2014.01.021","article-title":"Two miRNA clusters reveal alternative paths in late-stage reprogramming","volume":"14","author":"Parchem","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2026010206015564200_BIO062353C73","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.celrep.2015.06.074","article-title":"miR-302 is required for timing of neural differentiation, neural tube closure, and embryonic viability","volume":"12","author":"Parchem","year":"2015","journal-title":"Cell Rep."},{"key":"2026010206015564200_BIO062353C74","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/dvdy.21415","article-title":"System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in mice","volume":"237","author":"Park","year":"2008","journal-title":"Dev. Dyn."},{"key":"2026010206015564200_BIO062353C75","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature03076","article-title":"A pancreatic islet-specific microRNA regulates insulin secretion","volume":"432","author":"Poy","year":"2004","journal-title":"Nature"},{"key":"2026010206015564200_BIO062353C76","doi-asserted-by":"publisher","first-page":"5813","DOI":"10.1073\/pnas.0810550106","article-title":"miR-375 maintains normal pancreatic alpha- and beta-cell mass","volume":"106","author":"Poy","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026010206015564200_BIO062353C77","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1053\/j.gastro.2013.05.016","article-title":"Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6","volume":"145","author":"Pr\u00e9vot","year":"2013","journal-title":"Gastroenterology"},{"key":"2026010206015564200_BIO062353C78","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/j.stem.2021.10.003","article-title":"Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes","volume":"28","author":"Ramzy","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2026010206015564200_BIO062353C79","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"2026010206015564200_BIO062353C80","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13046-016-0321-3","article-title":"Inhibition of SOX2 induces cell apoptosis and G1\/S arrest in Ewing's sarcoma through the PI3K\/Akt pathway","volume":"35","author":"Ren","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"2026010206015564200_BIO062353C81","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2026010206015564200_BIO062353C82","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.3390\/ijms19041170","article-title":"MicroRNA expression analysis of in vitro dedifferentiated human pancreatic islet cells reveals the activation of the pluripotency-related microRNA cluster miR-302s","volume":"19","author":"Sebastiani","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2026010206015564200_BIO062353C83","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1073\/pnas.0609217104","article-title":"SOX9 is required for maintenance of the pancreatic progenitor cell pool","volume":"104","author":"Seymour","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026010206015564200_BIO062353C84","doi-asserted-by":"publisher","first-page":"100466","DOI":"10.1016\/j.xcrm.2021.100466","article-title":"Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device","volume":"2","author":"Shapiro","year":"2021","journal-title":"Cell Rep. Med."},{"key":"2026010206015564200_BIO062353C85","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.stem.2017.01.001","article-title":"Genome editing in hPSCs reveals GATA6 haploinsufficiency and a genetic interaction with GATA4 in human pancreatic development","volume":"20","author":"Shi","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2026010206015564200_BIO062353C86","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev-cellbio-101512-122405","article-title":"Pancreas organogenesis: from lineage determination to morphogenesis","volume":"29","author":"Shih","year":"2013","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2026010206015564200_BIO062353C87","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.2337\/db19-0349","article-title":"The Pdx1-bound Swi\/Snf chromatin remodeling complex regulates pancreatic progenitor cell proliferation and mature islet \u03b2-cell function","volume":"68","author":"Spaeth","year":"2019","journal-title":"Diabetes"},{"key":"2026010206015564200_BIO062353C88","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1053\/j.gastro.2013.01.074","article-title":"Control of cell identity in pancreas development and regeneration","volume":"144","author":"Stanger","year":"2013","journal-title":"Gastroenterology"},{"key":"2026010206015564200_BIO062353C89","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nature05537","article-title":"Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver","volume":"445","author":"Stanger","year":"2007","journal-title":"Nature"},{"key":"2026010206015564200_BIO062353C90","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1261\/rna.1211209","article-title":"Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription","volume":"15","author":"Tang","year":"2009","journal-title":"RNA"},{"key":"2026010206015564200_BIO062353C91","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1074\/mcp.M112.024786","article-title":"Argonaute2 regulates the pancreatic \u03b2-cell secretome","volume":"12","author":"Tattikota","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"2026010206015564200_BIO062353C92","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.cmet.2013.11.015","article-title":"Argonaute2 mediates compensatory expansion of the pancreatic \u03b2 cell","volume":"19","author":"Tattikota","year":"2014","journal-title":"Cell Metab."},{"key":"2026010206015564200_BIO062353C93","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/18884","article-title":"Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells","volume":"398","author":"Tetsu","year":"1999","journal-title":"Nature"},{"key":"2026010206015564200_BIO062353C94","doi-asserted-by":"publisher","first-page":"279ra38","DOI":"10.1126\/scitranslmed.3010841","article-title":"A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice","volume":"7","author":"Tian","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"2026010206015564200_BIO062353C95","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1095\/biolreprod.111.096313","article-title":"Two miRNA clusters, Mir-17-92 (Mirc1) and Mir-106b-25 (Mirc3), are involved in the regulation of spermatogonial differentiation in mice","volume":"86","author":"Tong","year":"2012","journal-title":"Biol. Reprod."},{"key":"2026010206015564200_BIO062353C96","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1172\/JCI129012","article-title":"The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas","volume":"130","author":"Valencia","year":"2020","journal-title":"J. Clin. Invest."},{"key":"2026010206015564200_BIO062353C97","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1073\/pnas.1212769110","article-title":"Critical regulation of miR-200\/ZEB2 pathway in Oct4\/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026010206015564200_BIO062353C98","doi-asserted-by":"publisher","first-page":"887","DOI":"10.2337\/db12-0451","article-title":"MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic \u03b2-cells","volume":"62","author":"Wang","year":"2013","journal-title":"Diabetes"},{"key":"2026010206015564200_BIO062353C99","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3892\/ijmm.2015.2267","article-title":"Autocrine motility factor receptor promotes the proliferation of human acute monocytic leukemia THP-1 cells","volume":"36","author":"Wang","year":"2015","journal-title":"Int. J. Mol. Med."},{"volume-title":"ggplot2 - Elegant Graphics for Data Analysis","year":"2016","author":"Wickham","key":"2026010206015564200_BIO062353C100"},{"key":"2026010206015564200_BIO062353C101","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"2026010206015564200_BIO062353C102","doi-asserted-by":"publisher","first-page":"109424","DOI":"10.1016\/j.biopha.2019.109424","article-title":"MiR-143-3p suppresses tumorigenesis in pancreatic ductal adenocarcinoma by targeting KRAS","volume":"119","author":"Xie","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"2026010206015564200_BIO062353C103","doi-asserted-by":"publisher","first-page":"54227","DOI":"10.18632\/oncotarget.17203","article-title":"G protein-coupled receptor kinase 6 is overexpressed in glioma and promotes glioma cell proliferation","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"2026010206015564200_BIO062353C104","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1172\/JCI63352","article-title":"Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis","volume":"122","author":"Xuan","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2026010206015564200_BIO062353C105","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1002\/bdr2.2178","article-title":"The role of noncoding RNAs in pancreatic birth defects","volume":"115","author":"Yang","year":"2023","journal-title":"Birth Defects Res."},{"key":"2026010206015564200_BIO062353C106","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.3892\/etm.2018.7112","article-title":"Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells in vitro and in vivo, and increases chemosensitivity to 5-fluorouracil and gemcitabine","volume":"17","author":"Yang","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"2026010206015564200_BIO062353C107","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1158\/1535-7163.MCT-09-0906","article-title":"Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein","volume":"9","author":"Yoshida","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"2026010206015564200_BIO062353C108","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1126\/science.1161431","article-title":"Generation and regeneration of cells of the liver and pancreas","volume":"322","author":"Zaret","year":"2008","journal-title":"Science"},{"key":"2026010206015564200_BIO062353C109","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/aps.2017.56","article-title":"WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cells","volume":"39","author":"Zhang","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"2026010206015564200_BIO062353C110","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1073\/pnas.0908750107","article-title":"MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026010206015564200_BIO062353C111","doi-asserted-by":"publisher","first-page":"31155","DOI":"10.1074\/jbc.M112.362632","article-title":"MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic \u03b2-cells","volume":"287","author":"Zhao","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2026010206015564200_BIO062353C112","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41586-018-0088-0","article-title":"Pancreas regeneration","volume":"557","author":"Zhou","year":"2018","journal-title":"Nature"},{"key":"2026010206015564200_BIO062353C113","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.2337\/db13-0151","article-title":"MicroRNA-24\/MODY gene regulatory pathway mediates pancreatic \u03b2-cell dysfunction","volume":"62","author":"Zhu","year":"2013","journal-title":"Diabetes"},{"key":"2026010206015564200_BIO062353C114","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.3892\/or.2016.5143","article-title":"Sulfatase 2 facilitates lymphangiogenesis in breast cancer by regulating VEGF-D","volume":"36","author":"Zhu","year":"2016","journal-title":"Oncol. Rep."}],"container-title":["Biology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.062353\/3676790\/bio062353.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.062353\/3679021\/bio062353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.062353\/3679021\/bio062353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T11:02:07Z","timestamp":1767351727000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/bio\/article\/15\/1\/bio062353\/370259\/miR-302-regulates-pancreatic-progenitor-pool-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":114,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1242\/bio.062353","relation":{},"ISSN":["2046-6390"],"issn-type":[{"type":"electronic","value":"2046-6390"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"article-number":"bio062353"}}