{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:16:05Z","timestamp":1775150165634,"version":"3.50.1"},"reference-count":132,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"crossref","award":["IN206724"],"award-info":[{"award-number":["IN206724"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"crossref","award":["IN210823"],"award-info":[{"award-number":["IN210823"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thyrotropin-releasing hormone (TRH) is a highly conserved tripeptide classically associated with regulation of the hypothalamic\u2013pituitary\u2013thyroid axis; however, TRH and its receptors are also widely distributed in peripheral metabolic tissues. While TRH has been implicated in glucose homeostasis in mammals, the developmental expression, tissue distribution, and sex-dependent metabolic roles of the TRHergic system in zebrafish remain poorly defined. Here, we characterized the TRHergic system in zebrafish (Danio rerio) by integrating bioinformatic analyses with developmental and adult expression profiling in both sexes, together with functional assessment under hyperglycemic conditions. TRHergic components \u2013 including pre proTRH, TRH receptor isoforms, and the TRH-degrading enzyme \u2013 were structurally conserved and dynamically expressed during early development, with trh-r1b displaying the most pronounced developmental changes. In adults, these genes exhibited broad central and peripheral expression with marked sex-specific patterns. In vivo, exogenous TRH reduced blood glucose levels in hyperglycemic males but not females. This effect was not associated with a direct insulinotropic response, supporting a modulatory role for TRH in metabolic regulation, likely involving peripheral tissues such as the pancreas and liver. Together, these findings establish zebrafish as a valuable vertebrate model for studying sex-dependent metabolic functions of the TRHergic system, particularly in the context of sex-dependent regulation of glucose homeostasis.<\/jats:p>","DOI":"10.1242\/bio.062418","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:26:02Z","timestamp":1772526362000},"source":"Crossref","is-referenced-by-count":0,"title":["Developmental and tissue-specific expression of thyrotropin-releasing hormone signaling genes in zebrafish and its association with glycemic regulation"],"prefix":"10.1242","volume":"15","author":[{"given":"David","family":"D\u00edaz-Orteg\u00f3n","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica Avanzada 1 Laboratorio de Epidemiolog\u00eda Traslacional , , Facultad de Medicina , , Quer\u00e9taro 76010 ,","place":["Mexico"]},{"name":"Universidad Aut\u00f3noma de Quer\u00e9taro 1 Laboratorio de Epidemiolog\u00eda Traslacional , , Facultad de Medicina , , Quer\u00e9taro 76010 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurea","family":"Orozco","sequence":"additional","affiliation":[{"name":"Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Campus Juriquilla 2 , Quer\u00e9taro 76230 ,","place":["Mexico"]},{"name":"Escuela Nacional de Estudios Superiores, Unidad Juriquilla, Universidad Nacional Aut\u00f3noma de M\u00e9xico 3 , Quer\u00e9taro 76230 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago M.","family":"Pech-Pool","sequence":"additional","affiliation":[{"name":"Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Campus Juriquilla 2 , Quer\u00e9taro 76230 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Carlota","family":"Garc\u00eda-Gutierrez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica Avanzada 1 Laboratorio de Epidemiolog\u00eda Traslacional , , Facultad de Medicina , , Quer\u00e9taro 76010 ,","place":["Mexico"]},{"name":"Universidad Aut\u00f3noma de Quer\u00e9taro 1 Laboratorio de Epidemiolog\u00eda Traslacional , , Facultad de Medicina , , Quer\u00e9taro 76010 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3971-3628","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Lazcano","sequence":"additional","affiliation":[{"name":"Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Campus Juriquilla 2 , Quer\u00e9taro 76230 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"2026040212250933900_BIO062418C1","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.yhbeh.2010.12.008","article-title":"Thyrotropin releasing hormone (TRH) in goldfish (Carassius auratus): role in the regulation of feeding and locomotor behaviors and interactions with the orexin system and cocaine- and amphetamine regulated transcript (CART)","volume":"59","author":"Abbott","year":"2011","journal-title":"Horm. 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