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Among other immune changes during malnutrition, effector T cells experience a decline in number and function. As little is known about the effect of malnutrition on na\u00efve T cells, we examined the impact of malnutrition on the na\u00efve T-cell population. During malnutrition, the number of na\u00efve T cells decreased in the lymph nodes and increased in the bone marrow, where na\u00efve CD4+ T cells experienced less apoptosis than controls. An adoptive transfer experiment revealed that malnourished na\u00efve CD4+ T cells preferentially migrated to the bone marrow, while ad libitum-fed control cells preferentially migrated to the lymph nodes in a T-cell-intrinsic fashion. Additionally, T-cell-specific lack of the glucocorticoid receptor greatly reduced the number of na\u00efve T cells in the bone marrow of malnourished mice, while dexamethasone treatment elevated the number of na\u00efve CD4+ T cells in the bone marrow. T-cell sensitivity to glucocorticoids was required for elevated expression of CXCR4 and CCR7 in na\u00efve CD4+ T cells during malnutrition. Overall, na\u00efve CD4+ T-cell migration to the bone marrow during malnutrition is intrinsic, requires sensitivity to glucocorticoids, and likely contributes to na\u00efve T-cell preservation in mice.<\/jats:p>","DOI":"10.1242\/bio.062485","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:23:59Z","timestamp":1776414239000},"source":"Crossref","is-referenced-by-count":0,"title":["Glucocorticoids intrinsically redirect na\u00efve CD4+ T cells to the bone marrow for preservation in malnourished mice"],"prefix":"10.1242","volume":"15","author":[{"given":"Madeline L.","family":"Smith","sequence":"first","affiliation":[{"name":"Randolph-Macon College 1 Department of Biology , , Ashland, VA 23005 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Hanes","sequence":"additional","affiliation":[{"name":"Randolph-Macon College 1 Department of Biology , , Ashland, VA 23005 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takesha R.","family":"Foster","sequence":"additional","affiliation":[{"name":"Randolph-Macon College 1 Department of Biology , , Ashland, VA 23005 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clay","family":"Phillips","sequence":"additional","affiliation":[{"name":"Randolph-Macon College 1 Department of Biology , , Ashland, VA 23005 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwesi A.","family":"Dadzie","sequence":"additional","affiliation":[{"name":"Randolph-Macon College 1 Department of Biology , , Ashland, VA 23005 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-3601","authenticated-orcid":false,"given":"Melanie R.","family":"Gubbels Bupp","sequence":"additional","affiliation":[{"name":"Randolph-Macon College 1 Department of Biology , , Ashland, VA 23005 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"2026051203185789200_BIO062485C1","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1080\/07315724.1986.10720158","article-title":"The effect of nutritional support on T-lymphocyte subpopulations in protein calorie malnutrition","volume":"5","author":"Abbott","year":"1986","journal-title":"J. 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