{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T10:31:37Z","timestamp":1787308297706,"version":"build-2736575974"},"reference-count":50,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Key Research and Development Project","award":["2025YFA1805403"],"award-info":[{"award-number":["2025YFA1805403"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32571354"],"award-info":[{"award-number":["32571354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32071147"],"award-info":[{"award-number":["32071147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Starvation induces robust food-seeking behavior in animals as a fundamental survival response. In Drosophila, biogenic amine octopamine (OA) plays a critical role in starvation-induced locomotor hyperactivity and awakeness, while the underlying signaling cascade remains not fully understood. Here, we demonstrated that the conserved transcription factor cAMP-Responsible Element Binding Protein (CREB), activated during starvation through the SIK2-CRTC pathway, contributes to starvation-induced sleep reduction. Mechanistically, we found that tyramine \u03b2-hydroxylase, the rate-limiting enzyme for OA synthesis, is upregulated by starvation in a CREB-dependent manner. Selective silencing of CREB in OA-producing neurons ameliorated OA-induced sleep suppression, and CREB loss-of-function mutations can partially rescue sleep fragmentation in a Drosophila model of Huntington's disease. Collectively, these findings reveal a novel regulatory role for CREB in sleep homeostasis through the transcriptional control of OA biosynthesis.<\/jats:p>","DOI":"10.1242\/bio.062570","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:55:36Z","timestamp":1786521336000},"source":"Crossref","is-referenced-by-count":0,"title":["CREB promotes starvation-induced sleep loss by regulating octopamine production in\n                    <i>Drosophila<\/i>"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1558-0478","authenticated-orcid":false,"given":"Shiye","family":"Zhu","sequence":"first","affiliation":[{"name":"Yangzhi Rehabilitation Hospital, Sunshine Rehabilitation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University Department of Gastroenterology , , Shanghai 20092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9540-169X","authenticated-orcid":false,"given":"Zhian","family":"Rao","sequence":"additional","affiliation":[{"name":"Yangzhi Rehabilitation Hospital, Sunshine Rehabilitation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University Department of Gastroenterology , , Shanghai 20092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjie","family":"Yin","sequence":"additional","affiliation":[{"name":"Yangzhi Rehabilitation Hospital, Sunshine Rehabilitation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University Department of Gastroenterology , , Shanghai 20092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Yangzhi Rehabilitation Hospital, Sunshine Rehabilitation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University Department of Gastroenterology , , Shanghai 20092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0720-2433","authenticated-orcid":false,"given":"Hansong","family":"Deng","sequence":"additional","affiliation":[{"name":"Yangzhi Rehabilitation Hospital, Sunshine Rehabilitation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University Department of Gastroenterology , , Shanghai 20092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"2026082106172783300_BIO062570C1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s41467-024-55371-y","article-title":"Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in","volume":"16","author":"Ahmad","year":"2025","journal-title":"Nat. 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