{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:45:19Z","timestamp":1782809119573,"version":"3.54.5"},"reference-count":32,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"NIH-NIGMS","award":["P20 GM103446"],"award-info":[{"award-number":["P20 GM103446"]}]},{"name":"NIH-NIGMS","award":["P40 0D010440"],"award-info":[{"award-number":["P40 0D010440"]}]},{"name":"NIH-NIGMS","award":["P20 GM113125"],"award-info":[{"award-number":["P20 GM113125"]}]},{"name":"NIH-NIGMS","award":["P20 GM139760"],"award-info":[{"award-number":["P20 GM139760"]}]},{"name":"NIH-NIGMS","award":["R35 GM142524"],"award-info":[{"award-number":["R35 GM142524"]}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Development requires the fusion of two gametes each with a haploid complement of DNA and the necessary components (RNA, proteins, organelles) needed for early cellular processes and divisions. The C. elegans paternal-effect embryonic lethal gene, spe-11, is one of the few known sperm components required for normal development. Sperm-provided SPE-11 forms a complex with the oocyte protein OOPS-1 at fertilization that mediates egg activation events. In this manuscript, we identified SPSP-1, a sperm protein that is associated with SPE-11. We found that SPSP-1 co-localizes with SPE-11 during spermatogenesis and in spermatids. SPSP-1 does not appear to play a role in egg activation like SPE-11. However, SPSP-1 is required to produce normal levels of hermaphrodite sperm and for wild-type levels of embryonic viability.<\/jats:p>","DOI":"10.1242\/bio.062634","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:02:38Z","timestamp":1781506958000},"source":"Crossref","is-referenced-by-count":0,"title":["SPSP-1 is a sperm protein required for\n                    <i>C. elegans<\/i>\n                    hermaphrodite sperm production and embryogenesis"],"prefix":"10.1242","volume":"15","author":[{"given":"Darline","family":"Murat","sequence":"first","affiliation":[{"name":"University of Delaware 1 Department of Biological Sciences , , Newark, Delaware 19716 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Nagorski","sequence":"additional","affiliation":[{"name":"University of Delaware 1 Department of Biological Sciences , , Newark, Delaware 19716 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Kent","family":"Kwah","sequence":"additional","affiliation":[{"name":"University of Delaware 1 Department of Biological Sciences , , Newark, Delaware 19716 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4662-7144","authenticated-orcid":false,"given":"Shannon","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"University of Delaware 1 Department of Biological Sciences , , Newark, Delaware 19716 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Duker","sequence":"additional","affiliation":[{"name":"University of Delaware 1 Department of Biological Sciences , , Newark, Delaware 19716 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"D\u00f6ring","sequence":"additional","affiliation":[{"name":"University of Kiel 2 Department of Molecular Prevention , , 24106 Kiel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-8580","authenticated-orcid":false,"given":"Aimee","family":"Jaramillo-Lambert","sequence":"additional","affiliation":[{"name":"University of Delaware 1 Department of Biological Sciences , , Newark, Delaware 19716 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"2026063004050286400_BIO062634C1","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1534\/genetics.116.192997","article-title":"Maternal MEMI promotes female meiosis II in response to fertilization in caenorhabditis elegans","volume":"204","author":"Ataeian","year":"2016","journal-title":"Genetics"},{"key":"2026063004050286400_BIO062634C2","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1242\/dev.122.1.391","article-title":"A sperm-supplied factor required for embryogenesis in C. elegans","volume":"122","author":"Browning","year":"1996","journal-title":"Development"},{"key":"2026063004050286400_BIO062634C3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/978-1-4614-4015-4_7","article-title":"Spermatogenesis","volume":"757","author":"Chu","year":"2013","journal-title":"Adv. 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